Search Results - "Freund, Isabel"

RNA Modifications Modulate Activation of Innate Toll-Like Receptors by Freund, Isabel, Eigenbrod, Tatjana, Helm, Mark, Dalpke, Alexander H

“…Self/foreign discrimination by the innate immune system depends on receptors that identify molecular patterns as associated to pathogens. Among others, this…”
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Bacterial tRNA 2′-O-methylation is dynamically regulated under stress conditions and modulates innate immune response by Galvanin, Adeline, Vogt, Lea-Marie, Grober, Antonia, Freund, Isabel, Ayadi, Lilia, Bourguignon-Igel, Valerie, Bessler, Larissa, Jacob, Dominik, Eigenbrod, Tatjana, Marchand, Virginie, Dalpke, Alexander, Helm, Mark, Motorin, Yuri

“…Abstract RNA modifications are a well-recognized way of gene expression regulation at the post-transcriptional level. Despite the importance of this level of…”
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Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7 by Keller, Patrick, Freund, Isabel, Marchand, Virginie, Bec, Guillaume, Huang, Raven, Motorin, Yuri, Eigenbrod, Tatjana, Dalpke, Alexander, Helm, Mark

“…Abstract Sensing of nucleic acids for molecular discrimination between self and non-self is a challenging task for the innate immune system. RNA acts as a…”
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Identification of an optimized 2'- O -methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8 by Schmitt, Felix C F, Freund, Isabel, Weigand, Markus A, Helm, Mark, Dalpke, Alexander H, Eigenbrod, Tatjana

“…Bacterial RNA serves an important function as activator of the innate immune system. In humans bacterial RNA is sensed by the endosomal receptors TLR7 and…”
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Next-Generation Sequencing-Based RiboMethSeq  Protocol for Analysis of tRNA 2'-O-Methylation by Marchand, Virginie, Pichot, Florian, Thüring, Kathrin, Ayadi, Lilia, Freund, Isabel, Dalpke, Alexander, Helm, Mark, Motorin, Yuri

“…Analysis of RNA modifications by traditional physico-chemical approaches is labor  intensive,  requires  substantial  amounts  of  input  material  and  only …”
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Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo by Hafner, Anna, Kolbe, Ulrike, Freund, Isabel, Castiglia, Virginia, Kovarik, Pavel, Poth, Tanja, Herster, Franziska, Weigand, Markus A, Weber, Alexander N R, Dalpke, Alexander H, Eigenbrod, Tatjana

“…is a major human pathogen causing a variety of diseases ranging from common pharyngitis to life-threatening soft tissue infections and sepsis. Microbial…”
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Fractionation-Dependent Radiosensitization by Molecular Targeting of Nek1 by Freund, Isabel, Hehlgans, Stephanie, Martin, Daniel, Ensminger, Michael, Fokas, Emmanouil, Rödel, Claus, Löbrich, Markus, Rödel, Franz

“…NIMA (never-in-mitosis gene A)-related kinase 1 (Nek1) is shown to impact on different cellular pathways such as DNA repair, checkpoint activation, and…”
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2'- O -methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms by Freund, Isabel, Buhl, Daniel K, Boutin, Sébastien, Kotter, Annika, Pichot, Florian, Marchand, Virginie, Vierbuchen, Tim, Heine, Holger, Motorin, Yuri, Helm, Mark, Dalpke, Alexander H, Eigenbrod, Tatjana

“…Bacterial RNA has emerged as an important activator of innate immune responses by stimulating Toll-like receptors TLR7 and TLR8 in humans. Guanosine 2'-…”
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Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7 by Hellmuth, Isabell, Freund, Isabel, Schlöder, Janine, Seidu-Larry, Salifu, Thüring, Kathrin, Slama, Kaouthar, Langhanki, Jens, Kaloyanova, Stefka, Eigenbrod, Tatjana, Krumb, Matthias, Röhm, Sandra, Peneva, Kalina, Opatz, Till, Jonuleit, Helmut, Dalpke, Alexander H, Helm, Mark

“…A fundamental mechanism of the innate immune system is the recognition, extra- and intracellular pattern-recognition receptors, of pathogen-associated…”
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