Search Results - "Freund, GG"

IL-1β-Mediated Innate Immunity Is Amplified in the db/db Mouse Model of Type 2 Diabetes by O’Connor, Jason C., Satpathy, Ansuman, Hartman, Matthew E., Horvath, Emily M., Kelley, Keith W., Dantzer, Robert, Johnson, Rodney W., Freund, Gregory G.

“…Abstract Chronic inflammation appears to play a critical role in type 2 diabetes and its complications. Here we tested the hypothesis that this inflammatory…”
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Interleukin-10 in the brain by Strle, K, Zhou, J H, Shen, W H, Broussard, S R, Johnson, R W, Freund, G G, Dantzer, R, Kelley, K W

“…Interleukin (IL)-10 is synthesized in the central nervous system (CNS) and acts to limit clinical symptoms of stroke, multiple sclerosis, Alzheimer's disease,…”
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Proinflammatory Cytokine Impairment of Insulin-Like Growth Factor I-Induced Protein Synthesis in Skeletal Muscle Myoblasts Requires Ceramide by Strle, Klemen, Broussard, Suzanne R, McCusker, Robert H, Shen, Wen-Hong, Johnson, Rodney W, Freund, Gregory G, Dantzer, Robert, Kelley, Keith W

“…GH and IGF-I control over 80% of postnatal growth. We recently established that TNFα impairs the ability of IGF-I to increase protein synthesis and promote…”
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Cytokine-Hormone Interactions: Tumor Necrosis Factor α Impairs Biologic Activity and Downstream Activation Signals of the Insulin-Like Growth Factor I Receptor in Myoblasts by Broussard, Suzanne R, MCCusker, Robert H, Novakofski, Jan E, Strle, Klemen, Hong Shen, Wen, Johnson, Rodney W, Freund, Gregory G, Dantzer, Robert, Kelley, Keith W

“…TNFα is elevated following damage to skeletal muscle. Here we provide evidence that TNFα acts on muscle cells to induce a state of IGF-I receptor resistance…”
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Proinflammatory cytokines block growth of breast cancer cells by impairing signals from a growth factor receptor by SHEN, Wen-Hong, ZHOU, Jian-Hua, BROUSSARD, Suzanne R, FREUND, Gregory G, DANTZER, Robert, KELLEY, Keith W

“…Neutralization of endogenous growth factors and administration of exogenous bioactive cytokines are two distinct biological antitumor strategies that show…”
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Inhibition of Vagally Mediated Immune-to-Brain Signaling by Vanadyl Sulfate Speeds Recovery from Sickness by Daniel R. Johnson, Jason C. O'Connor, Dantzer, Robert, Gregory G. Freund

“…To the ill patient with diabetes, the behavioral symptoms of sickness such as fatigue and apathy are debilitating and can prevent recuperation. Here we report…”
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Methylglyoxal Enhances Cisplatin-induced Cytotoxicity by Activating Protein Kinase Cδ by Godbout, Jonathan P., Pesavento, James, Hartman, Matthew E., Manson, Scott R., Freund, Gregory G.

“…The cytotoxic side effects of anti-neoplastic drugs are increased in patients with either type 1 or type 2 diabetes mellitus by a mechanism that is not clearly…”
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Macrophage hypo-responsiveness to interferon-γ in aged mice is associated with impaired signaling through Jak-STAT by Yoon, P., Keylock, K.T., Hartman, M.E., Freund, G.G., Woods, J.A.

“…Since macrophages (Mφs) are a first line of defense against pathogens, and are involved in both innate and adaptive immunity, understanding the impact of aging…”
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Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscle by Baum, Jamie I, O'Connor, Jason C, Seyler, Jennifer E, Anthony, Tracy G, Freund, Gregory G, Layman, Donald K

“…Leucine (Leu) is known to stimulate translation initiation of protein synthesis at mammalian target of rapamycin (mTOR) in the insulin signaling pathway…”
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IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCδ by Deszo, Eric L., Brake, Danett K., Kelley, Keith W., Freund, Gregory G.

“…CD86 expression is up-regulated in activated monocytes and macrophages by a mechanism that is not clearly defined. Here, we report that IL-4-dependent CD86…”
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Insulin Receptor Substrate-2-dependent Interleukin-4 Signaling in Macrophages Is Impaired in Two Models of Type 2 Diabetes Mellitus by Hartman, Matthew E., O'Connor, Jason C., Godbout, Jonathan P., Minor, Kyle D., Mazzocco, Valerie R., Freund, Gregory G.

“…We have shown previously that hyperinsulinemia inhibits interferon-α-dependent activation of phosphatidylinositol 3-kinase (PI3-kinase) through mammalian…”
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Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor by Minshall, C, Arkins, S, Freund, GG, Kelley, KW

“…Hemopoietic growth factors promote survival of progenitor cells by preventing their apoptotic death. Recently, phosphatidylinositol 3'-kinase (PI 3-kinase) has…”
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Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I by Liu, Q, Ning, W, Dantzer, R, Freund, G G, Kelley, K W

“…Phosphoinositides that are phosphorylated at the D3 position have been reported to activate an atypical, Ca2-independent protein kinase C (PKC) isoform…”
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Tumor Necrosis Factor α Inhibits Cyclin A Expression and Retinoblastoma Hyperphosphorylation Triggered by Insulin-like Growth Factor-I Induction of New E2F-1 Synthesis by Shen, Wen Hong, Yin, Yuxin, Broussard, Suzanne R., McCusker, Robert H., Freund, Gregory G., Dantzer, Robert, Kelley, Keith W.

“…Cyclin A is required for cell cycle S phase entry, and its overexpression contributes to tumorigenesis. Release of pre-existing E2Fs from inactive complexes of…”
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IL-10 Inhibits Apoptosis of Promyeloid Cells by Activating Insulin Receptor Substrate-2 and Phosphatidylinositol 3'-Kinase by Zhou, Jian-Hua, Broussard, Suzanne R, Strle, Klemen, Freund, Gregory G, Johnson, Rodney W, Dantzer, Robert, Kelley, Keith W

“…IL-10 is well known to be a potent inhibitor of the synthesis of proinflammatory cytokines, but noninflammatory hemopoietic cells also express IL-10Rs. Here we…”
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IL-10 promotes survival of microglia without activating Akt by Strle, Klemen, Zhou, Jian-Hua, Broussard, Suzanne R, Venters, Homer D, Johnson, Rodney W, Freund, Gregory G, Dantzer, Robert, Kelley, Keith W

“…IL-10 is an anti-inflammatory cytokine that has recently been shown to promote survival of neurons and glia. Here we establish that IL-10 induces…”
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IL-1β Suppresses Prolonged Akt Activation and Expression of E2F-1 and Cyclin A in Breast Cancer Cells by Shen, Wen Hong, Jackson, Steve T., Broussard, Suzanne R., McCusker, Robert H., Strle, Klemen, Freund, Gregory G., Johnson, Rodney W., Dantzer, Robert, Kelley, Keith W.

“…Abstract Cell cycle aberrations occurring at the G1/S checkpoint often lead to uncontrolled cell proliferation and tumor growth. We recently demonstrated that…”
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IL-4 and insulin-like growth factor-I inhibit the decline in Bcl-2 and promote the survival of IL-3-deprived myeloid progenitors by Minshall, C, Arkins, S, Straza, J, Conners, J, Dantzer, R, Freund, GG, Kelley, KW

“…The proto-oncogene product Bcl-2 regulates cell survival in both the immune and central nervous systems. We withdrew growth factors from IL-3-dependent murine…”
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JAK1-dependent Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) Is Inhibited by IRS-1 Serine Phosphorylation by Cengel, Keith A., Freund, Gregory G.

“…Serine phosphorylation of insulin receptor substrate-1 (IRS-1) reduces its ability to act as an insulin receptor substrate and inhibits insulin receptor signal…”
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FRAP-Dependent Serine Phosphorylation of IRS-1 Inhibits IRS-1 Tyrosine Phosphorylation by Hartman, Matthew E., Villela-Bach, Montserrat, Chen, Jie, Freund, Gregory G.

“…We have previously shown that interferon-α (IFNα)-dependent tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) is impaired by serine…”
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