Search Results - "Freund, C T"

Combination of adenovirus-mediated thymidine kinase gene therapy with cytotoxic chemotherapy in bladder cancer in vitro by Freund, C.T.F., Tong, X.-W., Rowley, D., Engehausen, D., Frolov, A., Kieback, D.G., Lerner, Seth P.

“…We evaluated efficacy, toxicity and potential synergism of adenoviral-mediated thymidine kinase (tk)- ganciclovir (GCV) gene therapy in combination with 4…”
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Adenovirus-mediated combination suicide and cytokine gene therapy for bladder cancer by Freund, C T, Sutton, M A, Dang, T, Contant, C F, Rowley, D, Lerner, S P

“…The present study tests the hypothesis that adenovirus-mediated transfer of murine IL-2 (ADV/RSV-mIL-2) alone or in combination with HSV-tk + GCV will improve…”
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Adenovirus mediated thymidine kinase gene therapy may enhance sensitivity of ovarian cancer cells to chemotherapeutic agents by Tong, X, Shine, D H, Agoulnik, I, Freund, C T, Hasenburg, A, Aguilar-Cordova, E, Woo, S L, Kieback, D G

“…The current treatment concept of ovarian cancer consists of radical surgery with subsequent chemotherapy. We have shown that adenovirus (ADV) mediated…”
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Improvement of gene therapy for ovarian cancer by using acyclovir instead of ganciclovir in adenovirus mediated thymidine kinase gene therapy by Tong, X W, Engehausen, D G, Kaufman, R H, Agoulnik, I, Contant, C, Freund, C T, Oehler, M K, Kim, T E, Hasenburg, A, Woo, S L, Kieback, D G

“…Adenovirus(ADV) mediated thymidine kinase(TK) gene therapy followed by ganciclovir(GCV) administration is widely used in different types of cancer. ACV shares…”
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The efficacy of adenovirus-mediated gene therapy of ovarian cancer is enhanced by using the cytomegalovirus promoter by Tong, X, Engehausen, D G, Freund, C T, Agoulnik, I, Guo, Z, Oehler, M K, Kim, T E, Hasenburg, A, Contant, C F, Woo, S L, Kieback, D G

“…The cytomegalovirus(CMV) promoter is considered one of the strongest positive regulators. In this study toxicity, cell killing efficacy and bystander effect of…”
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Androgen receptor gene mutations do not occur in ovarian cancer by Engehausen, D G, Tong, X W, Oehler, M K, Freund, C T, Schrott, K M, Kieback, D G

“…Genetic alterations have been frequently found in ovarian cancer. There is some indirect evidence indicating that mutation of the steroid receptor genes may…”
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Predicting prostate-cancer-specific death: Is it in the cancer? by Ayala, G. E., Miles, B. J., Freund, C. T., Li, R., Frolov, A., Ittmann, M. M., Kadmon, D., Scardino, P. T., Wheeler, T., Rowley, D.

“…Abstract only…”
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In Vivo Adenovirus-Mediated Suicide Gene Therapy of Orthotopic Bladder Cancer by Sutton, Mark A., Freund, Christian T.M., Berkman, Scott A., Dang, Truong D., Kattan, Michael W., Wheeler, Thomas M., Rowley, David R., Lemer, Seth P.

“…These studies were undertaken to determine the feasibility, safety, and efficacy of suicide gene therapy using adenoviral-mediated herpes simplex virus…”
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Gene therapy of metastatic colon carcinoma: regression of multiple hepatic metastases by adenoviral expression of bacterial cytosine deaminase by Block, A, Freund, C T, Chen, S H, Nguyen, K P, Finegold, M, Windler, E, Woo, S L

“…Colon carcinoma accounts for 20% of deaths due to malignancies in the Western world. Once metastases occur, therapeutic options are limited, with an…”
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Adenovirus-mediated suicide gene therapy for bladder cancer: comparison of the cytomegalovirus- and Rous sarcoma virus-promoter by Freund, C T, Tong, X W, Block, A, Contant, C F, Kieback, D G, Rowley, D R, Lerner, S P

“…To compare efficacy and toxicity of the human cytomegalovirus-immediate-early (CMV) promoter and the Rous-sarcoma-virus (RSV) promoter to express thymidine…”
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Comparison of long-term survival of cytomegalovirus promotre versus Rous Sarcoma virus promoter-driven thymidine kinase gene therapy in nude mice bearing human ovarian cancer by Tong, X, Engehausen, D G, Freund, C T, Agoulnik, I, Oehler, M K, Kim, T E, Hasenburg, A, Guo, Z, Contant, C F, Woo, S L, Kieback, D G

“…The cytomegalovirus (CMV) promoter is considered one of the strongest positive regulators leading to expression of higher levels of the thymidine kinase (TK)…”
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