Search Results - "Freund, Adam"

Lamin B1 loss is a senescence-associated biomarker by Freund, Adam, Laberge, Remi-Martin, Demaria, Marco, Campisi, Judith

“…Cellular senescence is a potent tumor-suppressive mechanism that arrests cell proliferation and has been linked to aging. However, studies of senescence have…”
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Inflammatory networks during cellular senescence: causes and consequences by Freund, Adam, Orjalo, Arturo V, Desprez, Pierre-Yves, Campisi, Judith

“…Chronic inflammation is associated with aging and plays a causative role in several age-related diseases such as cancer, atherosclerosis and osteoarthritis…”
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Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells by Mou, Hongmei, Vinarsky, Vladimir, Tata, Purushothama Rao, Brazauskas, Karissa, Choi, Soon H., Crooke, Adrianne K., Zhang, Bing, Solomon, George M., Turner, Brett, Bihler, Hermann, Harrington, Jan, Lapey, Allen, Channick, Colleen, Keyes, Colleen, Freund, Adam, Artandi, Steven, Mense, Martin, Rowe, Steven, Engelhardt, John F., Hsu, Ya-Chieh, Rajagopal, Jayaraj

“…Functional modeling of many adult epithelia is limited by the difficulty in maintaining relevant stem cell populations in culture. Here, we show that dual…”
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Proteostatic Control of Telomerase Function through TRiC-Mediated Folding of TCAB1 by Freund, Adam, Zhong, Franklin L., Venteicher, Andrew S., Meng, Zhaojing, Veenstra, Timothy D., Frydman, Judith, Artandi, Steven E.

“…Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex…”
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TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends by Zhong, Franklin L., Batista, Luis F.Z., Freund, Adam, Pech, Matthew F., Venteicher, Andrew S., Artandi, Steven E.

“…Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal bodies, and telomerase is thought to be recruited to telomeres…”
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Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging by Muñoz, Denise P, Yannone, Steven M, Daemen, Anneleen, Sun, Yu, Vakar-Lopez, Funda, Kawahara, Misako, Freund, Adam M, Rodier, Francis, Wu, Jennifer D, Desprez, Pierre-Yves, Raulet, David H, Nelson, Peter S, van 't Veer, Laura J, Campisi, Judith, Coppé, Jean-Philippe

“…Cellular senescence is a tumor suppressive mechanism that can paradoxically contribute to aging pathologies. Despite evidence of immune clearance in mouse…”
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Novel insights from a multiomics dissection of the Hayflick limit by Chan, Michelle, Yuan, Han, Soifer, Ilya, Maile, Tobias M, Wang, Rebecca Y, Ireland, Andrea, O'Brien, Jonathon J, Goudeau, Jérôme, Chan, Leanne J G, Vijay, Twaritha, Freund, Adam, Kenyon, Cynthia, Bennett, Bryson D, McAllister, Fiona E, Kelley, David R, Roy, Margaret, Cohen, Robert L, Levinson, Arthur D, Botstein, David, Hendrickson, David G

“…The process wherein dividing cells exhaust proliferative capacity and enter into replicative senescence has become a prominent model for cellular aging in…”
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Age and diet shape the genetic architecture of body weight in diversity outbred mice by Wright, Kevin M, Deighan, Andrew G, Di Francesco, Andrea, Freund, Adam, Jojic, Vladimir, Churchill, Gary A, Raj, Anil

“…Understanding how genetic variation shapes a complex trait relies on accurately quantifying both the additive genetic and genotype–environment interaction…”
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Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice by Chen, Zhenghao, Raj, Anil, Prateek, G V, Di Francesco, Andrea, Liu, Justin, Keyes, Brice E, Kolumam, Ganesh, Jojic, Vladimir, Freund, Adam

“…Behavior and physiology are essential readouts in many studies but have not benefited from the high-dimensional data revolution that has transformed molecular…”
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Resistance welding of glass fiber reinforced PET: Effect of weld pressure and heating element geometry by Warren, Kyle C, Lopez-Anido, Roberto A, Freund, Adam L, Dagher, Habib J

“…The objective of this paper is to present an investigation of resistance welded thermoplastic joints using stainless steel wire mesh and polyethylene…”
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Untangling Aging Using Dynamic, Organism-Level Phenotypic Networks by Freund, Adam

“…Research on aging requires the ability to measure aging, and therein lies a challenge: it is impossible to measure every molecular, cellular, and physiological…”
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Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype by Coppé, Jean-Philippe, Rodier, Francis, Patil, Christopher K., Freund, Adam, Desprez, Pierre-Yves, Campisi, Judith

“…Cellular senescence suppresses cancer by preventing the proliferation of cells that experience potentially oncogenic stimuli. Senescent cells often express…”
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p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype by Freund, Adam, Patil, Christopher K, Campisi, Judith

“…Cellular senescence suppresses cancer by forcing potentially oncogenic cells into a permanent cell cycle arrest. Senescent cells also secrete growth factors,…”
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Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype by Coppé, Jean-Philippe, Rodier, Francis, Patil, Christopher K, Freund, Adam, Desprez, Pierre-Yves, Campisi, Judith

“…Cellular senescence suppresses cancer by preventing the proliferation of cells that experience potentially oncogenic stimuli. Senescent cells often express…”
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Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype by Wiley, Christopher D., Velarde, Michael C., Lecot, Pacome, Liu, Su, Sarnoski, Ethan A., Freund, Adam, Shirakawa, Kotaro, Lim, Hyung W., Davis, Sonnet S., Ramanathan, Arvind, Gerencser, Akos A., Verdin, Eric, Campisi, Judith

“…Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). Loss of…”
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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation by Laberge, Remi-Martin, Sun, Yu, Orjalo, Arturo V., Patil, Christopher K., Freund, Adam, Zhou, Lili, Curran, Samuel C., Davalos, Albert R., Wilson-Edell, Kathleen A., Liu, Su, Limbad, Chandani, Demaria, Marco, Li, Patrick, Hubbard, Gene B., Ikeno, Yuji, Javors, Martin, Desprez, Pierre-Yves, Benz, Christopher C., Kapahi, Pankaj, Nelson, Peter S., Campisi, Judith

“…The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates…”
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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion by Campisi, Judith, Davalos, Albert R, Hoeijmakers, Wieteke A. M, Muñoz, Denise P, Campeau, Eric, Raza, Saba R, Patil, Christopher K, Rodier, Francis, Coppé, Jean-Philippe, Freund, Adam

“…Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells. Paradoxically, senescent cells also secrete factors that alter…”
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Time-Resolved Shadowgraph Photography of Laser-Heated Plasmonic Gold Nanoparticles in Water by Stavich, Derek, Nestoiter, Boris, Gonzalez, Daniel, Freund, Adam, Buelna, Xavier, Wang, Kaiyue, Teprovich, Joseph A, Eloranta, Jussi

“…Fragmentation and the subsequent heat transfer from solvated gold nanoparticles with sizes 50, 100, 150, and 250 nm to water are studied by time-resolved…”
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An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1 by Chen, Lu, Roake, Caitlin M., Freund, Adam, Batista, Pedro J., Tian, Siqi, Yin, Yi A., Gajera, Chandresh R., Lin, Shengda, Lee, Byron, Pech, Matthew F., Venteicher, Andrew S., Das, Rhiju, Chang, Howard Y., Artandi, Steven E.

“…Ribonucleoprotein enzymes require dynamic conformations of their RNA constituents for regulated catalysis. Human telomerase employs a non-coding RNA (hTR) with…”
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Ejection of Metal Particles into Superfluid 4 He by Laser Ablation by Buelna, Xavier, Freund, Adam, Gonzalez, Daniel, Popov, Evgeny, Eloranta, Jussi

“…The dynamics of laser ablation of a metal target immersed in superfluid He is studied through time-resolved shadowgraph photography. Delayed ejection of hot…”
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