Search Results - "Freshour, Judy"
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Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development
Published in PLoS genetics (15-05-2023)“…An essential process during Danio rerio's left-right organizer (Kupffer's Vesicle, KV) formation is the formation of a motile cilium by developing KV cells…”
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Chlamydomonas axonemal dynein assembly locus ODA8 encodes a conserved flagellar protein needed for cytoplasmic maturation of outer dynein arm complexes
Published in Cytoskeleton (Hoboken, N.J.) (01-01-2015)“…The Chlamydomonas reinhardtii oda8 mutation blocks assembly of flagellar outer dynein arms (ODAs), and interacts genetically with ODA5 and ODA10, which encode…”
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Gravin regulates centrosome function through PLK1
Published in Molecular biology of the cell (01-03-2018)“…We propose to understand how the mitotic kinase PLK1 drives chromosome segregation errors, with a specific focus on Gravin, a PLK1 scaffold. In both…”
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Loss-of-Function Mutations in the Human Ortholog of Chlamydomonas reinhardtii ODA7 Disrupt Dynein Arm Assembly and Cause Primary Ciliary Dyskinesia
Published in American journal of human genetics (11-12-2009)“…Cilia and flagella are evolutionarily conserved structures that play various physiological roles in diverse cell types. Defects in motile cilia result in…”
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Chlamydomonas Flagellar Outer Row Dynein Assembly Protein Oda7 Interacts with Both Outer Row and I1 Inner Row Dyneins
Published in The Journal of biological chemistry (23-02-2007)“…We previously found that a mutation at the ODA7 locus in Chlamydomonas prevents axonemal outer row dynein assembly by blocking association of heavy chains and…”
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Gender differences in cardiac ACE expression are normalized in androgen-deprived male mice
Published in American journal of physiology. Heart and circulatory physiology (01-11-2002)“…Gender differences have been described in the response of the cardiovascular system to a number of stimuli, including ventricular remodeling in response to…”
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Pericentriolar matrix (PCM) integrity relies on cenexin and polo-like kinase (PLK)1
Published in Molecular biology of the cell (01-08-2022)“…Polo-like-kinase (PLK) 1 activity is associated with maintaining the functional and physical properties of the centrosome's pericentriolar matrix (PCM). In…”
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Pericentriolar matrix 1
Published in Molecular biology of the cell (01-08-2022)“…Polo-like-kinase (PLK) 1 activity is associated with maintaining the functional and physical properties of the centrosome's pericentriolar matrix (PCM). In…”
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Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia
Published in Nature genetics (01-04-2012)“…David Mitchell, Hannah Mitchison and colleagues identify a new Chlamydomonas protein required for the preassembly of axonemal dyneins before their transport…”
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Chromosome misalignment is associated with PLK1 activity at cenexin-positive mitotic centrosomes
Published in Molecular biology of the cell (15-06-2019)“…The mitotic kinase, polo-like kinase 1 (PLK1), facilitates the assembly of the two mitotic spindle poles, which are required for the formation of the…”
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Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo
Published in Life science alliance (01-07-2022)“…The last stage of cell division involves two daughter cells remaining interconnected by a cytokinetic bridge that is cleaved during abscission. Conserved…”
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