Search Results - "Frese, Marcel"

A High-Throughput Fluorescence Assay to Determine the Activity of Tryptophan Halogenases by Schnepel, Christian, Minges, Hannah, Frese, Marcel, Sewald, Norbert

“…Biocatalytic halogenation with tryptophan halogenases is hampered by severe limitations such as low activity and stability. These drawbacks can be overcome by…”
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Antimicrobial Abietane-Type Diterpenoids from Plectranthus punctatus by Abdissa, Negera, Frese, Marcel, Sewald, Norbert

“…Four new -benzoquinone containing abietane-type diterpenoids ( - ) along with thirteen known diterpenoids ( - ) were isolated from the roots of . The…”
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A flavin-dependent halogenase from metagenomic analysis prefers bromination over chlorination by Neubauer, Pia R, Widmann, Christiane, Wibberg, Daniel, Schröder, Lea, Frese, Marcel, Kottke, Tilman, Kalinowski, Jörn, Niemann, Hartmut H, Sewald, Norbert

“…Flavin-dependent halogenases catalyse halogenation of aromatic compounds. In most cases, this reaction proceeds with high regioselectivity and requires only…”
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Cytotoxic Compounds from Aloe megalacantha by Abdissa, Negera, Gohlke, Sebastian, Frese, Marcel, Sewald, Norbert

“…Phytochemical investigation of the ethyl acetate extract of the roots of led to the isolation of four new natural products-1,8-dimethoxynepodinol ( ),…”
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Regioselective Enzymatic Halogenation of Substituted Tryptophan Derivatives using the FAD-Dependent Halogenase RebH by Frese, Marcel, Guzowska, Paulina H., Voß, Hauke, Sewald, Norbert

“…Regioselective methods to establish carbon–halide bonds are still rare, although halogenation is considered as a commonly used methodology for the…”
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Coumamarin: a first coumarinyl calcium complex isolated from nature by Hamed, Abdelaaty, Abdel-Razek, Ahmed S., Frese, Marcel, Sproß, Jens, Stammler, Hans Georg, Sewald, Norbert, Shaaban, Mohamed

“…The first calcium complex from nature, Coumamarin ( 1 ), 7-hydroxy-3-methoxy-2-oxo-2 H -chromene-6-carboxylate Ca(II) complex, was isolated from Aspergillus…”
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Chemical Constituents of Macaranga occidentalis , Antimicrobial and Chemophenetic Studies by Kamso, Viviane Flore Kamlo, Simo Fotso, Christophe Colombe, Kanko Mbekou, Ines Michèle, Tousssie, Billy Tchegnitegni, Ndjakou Lenta, Bruno, Boyom, Fabrice Fekam, Sewald, Norbert, Frese, Marcel, Ngadjui, Bonaventure Tchaleu, Wabo Fotso, Ghislain

“…Medicinal plants are known as sources of potential antimicrobial compounds belonging to different classes. The aim of the present work was to evaluate the…”
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Terretonin N: A New Meroterpenoid from Nocardiopsis sp by Hamed, Abdelaaty, Abdel-Razek, Ahmed S, Frese, Marcel, Stammler, Hans Georg, El-Haddad, Atef F, Ibrahim, Tarek M A, Sewald, Norbert, Shaaban, Mohamed

“…Terretonin N ( ), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl…”
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Coumarinolignoid and Indole Alkaloids from the Roots of the Hybrid Plant Citrus × paradisi Macfad (Rutaceae) by Essombe Malolo, Fanny-Aimée, Kouam, Ariane Dolly Kenmogne, Nyobe, Judith Caroline Ngo, Ngah, Lidwine, Frese, Marcel, Ndom, Jean Claude, Langat, Moses K, Lenta, Bruno Ndjakou, Mulholland, Dulcie A, Sewald, Norbert, Wansi, Jean Duplex

“…A phytochemical investigation of the roots of Macfad. (Rutaceae) led to the isolation of two new compounds, namely 1-formyl-5-hydroxy- -methylindolin-1-ium ( )…”
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Novel unit B cryptophycin analogues as payloads for targeted therapy by Figueras, Eduard, Borbély, Adina, Ismail, Mohamed, Frese, Marcel, Sewald, Norbert

“…Cryptophycins are naturally occurring cytotoxins with great potential for chemotherapy. Since targeted therapy provides new perspectives for treatment of…”
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Synthesis and Biological Evaluation of RGD⁻Cryptophycin Conjugates for Targeted Drug Delivery by Borbély, Adina, Figueras, Eduard, Martins, Ana, Esposito, Simone, Auciello, Giulio, Monteagudo, Edith, Di Marco, Annalise, Summa, Vincenzo, Cordella, Paola, Perego, Raffaella, Kemker, Isabell, Frese, Marcel, Gallinari, Paola, Steinkühler, Christian, Sewald, Norbert

“…Cryptophycins are potent tubulin polymerization inhibitors with picomolar antiproliferative potency in vitro and activity against multidrug-resistant (MDR)…”
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Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR by Eliwa, Essam M., Frese, Marcel, Halawa, Ahmed H., Soltan, Maha M., Ponomareva, Larissa V., Thorson, Jon S., Shaaban, Khaled A., Shaaban, Mohamed, El-Agrody, Ahmed M., Sewald, Norbert

“…A metal-free, atom-economy and simple work-up domino amination-Knoevenagel condensation approach to construct new coumarin analogous (4a-f and 8a-e) was…”
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L-Carnitine Production Through Biosensor-Guided Construction of the Neurospora crassa Biosynthesis Pathway in Escherichia coli by Kugler, Pierre, Trumm, Marika, Frese, Marcel, Wendisch, Volker F

“…L-Carnitine is a bioactive compound derived from L-lysine and -adenosyl-L-methionine, which is closely associated with the transport of long-chain fatty acids…”
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Cytotoxicity, Antimicrobial, and In Silico Studies of Secondary Metabolites From Aspergillus sp. Isolated From Tecoma stans (L.) Juss. Ex Kunth Leaves by Elsayed, Heba E., Kamel, Reem A., Ibrahim, Reham R., Abdel-Razek, Ahmed S., Shaaban, Mohamed A., Frese, Marcel, Sewald, Norbert, Ebrahim, Hassan Y., Moharram, Fatma A.

“…Endophytes are prolific producers of privileged secondary metabolites with diverse therapeutic potential, although their anticancer and antimicrobial potential…”
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Octreotide Conjugates for Tumor Targeting and Imaging by Figueras, Eduard, Martins, Ana, Borbély, Adina, Le Joncour, Vadim, Cordella, Paola, Perego, Raffaella, Modena, Daniela, Pagani, Paolo, Esposito, Simone, Auciello, Giulio, Frese, Marcel, Gallinari, Paola, Laakkonen, Pirjo, Steinkühler, Christian, Sewald, Norbert

“…Tumor targeting has emerged as an advantageous approach to improving the efficacy and safety of cytotoxic agents or radiolabeled ligands that do not…”
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Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery by Borbély, Adina, Figueras, Eduard, Martins, Ana, Bodero, Lizeth, Raposo Moreira Dias, André, López Rivas, Paula, Pina, Arianna, Arosio, Daniela, Gallinari, Paola, Frese, Marcel, Steinkühler, Christian, Gennari, Cesare, Piarulli, Umberto, Sewald, Norbert

“…RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent…”
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Chemical Constituents of Nauclea vanderguchtii by Nkouayeb, Brice Maxime Nangmou, Azebaze, Anatole Guy Blaise, Tabekoueng, Georges Bellier, Tsopgn, Willifred Dongmo Tekapi, Lenta, Bruno Ndjakou, Frese, Marcel, Sewald, Norbert, Vardamides, Juliette Catherine

“…Phytochemical investigation of leaves, barks and roots of Nauclea vanderguchtii led to the isolation of sixteen compounds, which includes one citric acid…”
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Enzymatic Halogenation of Tryptophan on a Gram Scale by Frese, Marcel, Sewald, Norbert

“…Halogenated arenes are important building blocks in medicinal and agrochemistry. Chemical electrophilic aromatic halogenation requires molecular halogen,…”
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Chemical Constituents of Nauclea vanderguchtii by Nkouayeb, Brice Maxime Nangmou, Azebaze, Anatole Guy Blaise, Tabekoueng, Georges Bellier, Tsopgni, Willifred Dongmo Tekapi, Lenta, Bruno Ndjakou, Frese, Marcel, Sewald, Norbert, Vardamides, Juliette Catherine

“…Phytochemical investigation of leaves, barks and roots of Nauclea vanderguchtii led to the isolation of sixteen compounds, which includes one citric acid…”
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Structure-based switch of regioselectivity in the flavin-dependent tryptophan 6-halogenase Thal by Moritzer, Ann-Christin, Minges, Hannah, Prior, Tina, Frese, Marcel, Sewald, Norbert, Niemann, Hartmut H.

“…Flavin-dependent halogenases increasingly attract attention as biocatalysts in organic synthesis, facilitating environmentally friendly halogenation strategies…”
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