Search Results - "Frese, K K"

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer by Hessmann, E, Patzak, M S, Klein, L, Chen, N, Kari, V, Ramu, I, Bapiro, T E, Frese, K K, Gopinathan, A, Richards, F M, Jodrell, D I, Verbeke, C, Li, X, Heuchel, R, Löhr, J M, Johnsen, S A, Gress, T M, Ellenrieder, V, Neesse, A

“…Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have…”
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Stromal biology and therapy in pancreatic cancer by Neesse, Albrecht, Michl, Patrick, Frese, Kristopher K, Feig, Christine, Cook, Natalie, Jacobetz, Mike A, Lolkema, Martijn P, Buchholz, Malte, Olive, Kenneth P, Gress, Thomas M, Tuveson, David A

“…Pancreatic ductal adenocarcinoma (PDA) is an almost uniformly lethal disease. One explanation for the devastating prognosis is the failure of many…”
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Comprehensive Identification of RNA-Binding Domains in Human Cells by Castello, Alfredo, Fischer, Bernd, Frese, Christian K., Horos, Rastislav, Alleaume, Anne-Marie, Foehr, Sophia, Curk, Tomaz, Krijgsveld, Jeroen, Hentze, Matthias W.

“…Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of these employing unknown modes of RNA binding. We developed RBDmap to…”
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Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring by Cagnetta, Roberta, Wong, Hovy Ho-Wai, Frese, Christian K., Mallucci, Giovanna R., Krijgsveld, Jeroen, Holt, Christine E.

“…Local translation is rapidly regulated by extrinsic signals during neural wiring, but its control mechanisms remain elusive. Here we show that the…”
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The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease by Liao, Yalin, Castello, Alfredo, Fischer, Bernd, Leicht, Stefan, Föehr, Sophia, Frese, Christian K., Ragan, Chikako, Kurscheid, Sebastian, Pagler, Eloisa, Yang, Hao, Krijgsveld, Jeroen, Hentze, Matthias W., Preiss, Thomas

“…RNA functions through the dynamic formation of complexes with RNA-binding proteins (RBPs) in all clades of life. We determined the RBP repertoire of beating…”
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Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila by Sysoev, Vasiliy O., Fischer, Bernd, Frese, Christian K., Gupta, Ishaan, Krijgsveld, Jeroen, Hentze, Matthias W., Castello, Alfredo, Ephrussi, Anne

“…The maternal-to-zygotic transition (MZT) is a process that occurs in animal embryos at the earliest developmental stages, during which maternally deposited…”
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nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer by Frese, Kristopher K, Neesse, Albrecht, Cook, Natalie, Bapiro, Tashinga E, Lolkema, Martijn P, Jodrell, Duncan I, Tuveson, David A

“…Nanoparticle albumin-bound (nab)-paclitaxel, an albumin-stabilized paclitaxel formulation, demonstrates clinical activity when administered in combination with…”
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CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer by Neesse, Albrecht, Frese, Kristopher K., Bapiro, Tashinga E., Nakagawa, Tomoaki, Sternlicht, Mark D., Seeley, Todd W., Pilarsky, Christian, Jodrell, Duncan I., Spong, Suzanne M., Tuveson, David A.

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant desmoplasia and poor tissue perfusion. These features are proposed to limit the access of…”
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Toward Full Peptide Sequence Coverage by Dual Fragmentation Combining Electron-Transfer and Higher-Energy Collision Dissociation Tandem Mass Spectrometry by Frese, Christian K, Altelaar, A. F. Maarten, van den Toorn, Henk, Nolting, Dirk, Griep-Raming, Jens, Heck, Albert J. R, Mohammed, Shabaz

“…Increasing peptide sequence coverage by tandem mass spectrometry improves confidence in database search-based peptide identification and facilitates mapping of…”
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The Rare YAP1 Subtype of SCLC Revisited in a Biobank of 39 Circulating Tumor Cell Patient Derived Explant Models: A Brief Report by Pearsall, Sarah M, Humphrey, Sam, Revill, Mitchell, Morgan, Derrick, Frese, Kristopher K, Galvin, Melanie, Kerr, Alastair, Carter, Mathew, Priest, Lynsey, Blackhall, Fiona, Simpson, Kathryn L, Dive, Caroline

“…Recent consensus defines four SCLC subtypes on the basis of transcription factor expression: ASCL1, NEUROD1, POU2F3, and YAP1. The rare YAP1 subtype is…”
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A salvage pathway maintains highly functional respiratory complex I by Szczepanowska, Karolina, Senft, Katharina, Heidler, Juliana, Herholz, Marija, Kukat, Alexandra, Höhne, Michaela Nicole, Hofsetz, Eduard, Becker, Christina, Kaspar, Sophie, Giese, Heiko, Zwicker, Klaus, Guerrero-Castillo, Sergio, Baumann, Linda, Kauppila, Johanna, Rumyantseva, Anastasia, Müller, Stefan, Frese, Christian K., Brandt, Ulrich, Riemer, Jan, Wittig, Ilka, Trifunovic, Aleksandra

“…Regulation of the turnover of complex I (CI), the largest mitochondrial respiratory chain complex, remains enigmatic despite huge advancement in understanding…”
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Unambiguous Phosphosite Localization using Electron-Transfer/Higher-Energy Collision Dissociation (EThcD) by Frese, Christian K, Zhou, Houjiang, Taus, Thomas, Altelaar, A. F. Maarten, Mechtler, Karl, Heck, Albert J. R, Mohammed, Shabaz

“…We recently introduced a novel scheme combining electron-transfer and higher-energy collision dissociation (termed EThcD), for improved peptide ion…”
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The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis by Schäfer, Heinrich, Beckert, Bertrand, Frese, Christian K, Steinchen, Wieland, Nuss, Aaron M, Beckstette, Michael, Hantke, Ingo, Driller, Kristina, Sudzinová, Petra, Krásný, Libor, Kaever, Volkhard, Dersch, Petra, Bange, Gert, Wilson, Daniel N, Turgay, Kürşad

“…Bacillus subtilis cells are well suited to study how bacteria sense and adapt to proteotoxic stress such as heat, since temperature fluctuations are a major…”
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Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo by Bapiro, T E, Frese, K K, Courtin, A, Bramhall, J L, Madhu, B, Cook, N, Neesse, A, Griffiths, J R, Tuveson, D A, Jodrell, D I, Richards, F M

“…Background: The modest benefits of gemcitabine (dFdC) therapy in patients with pancreatic ductal adenocarcinoma (PDAC) are well documented, with drug delivery…”
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Expanding the detectable HLA peptide repertoire using electron-transfer/higher-energy collision dissociation (EThcD) by Mommen, Geert P. M., Frese, Christian K., Meiring, Hugo D., van Gaans-van den Brink, Jacqueline, de Jong, Ad P. J. M., van Els, Cécile A. C. M., Heck, Albert J. R.

“…The identification of peptides presented by human leukocyte antigen (HLA) class I is tremendously important for the understanding of antigen presentation…”
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Quantitative Map of Proteome Dynamics during Neuronal Differentiation by Frese, Christian K., Mikhaylova, Marina, Stucchi, Riccardo, Gautier, Violette, Liu, Qingyang, Mohammed, Shabaz, Heck, Albert J.R., Altelaar, A.F. Maarten, Hoogenraad, Casper C.

“…Neuronal differentiation is a multistep process that shapes and re-shapes neurons by progressing through several typical stages, including axon outgrowth,…”
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Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models by Khandelwal, Garima, Girotti, María Romina, Smowton, Christopher, Taylor, Sam, Wirth, Christopher, Dynowski, Marek, Frese, Kristopher K, Brady, Ged, Dive, Caroline, Marais, Richard, Miller, Crispin

“…Patient-derived xenograft (PDX) and circulating tumor cell-derived explant (CDX) models are powerful methods for the study of human disease. In cancer…”
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Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories by Hynds, Robert E, Frese, Kristopher K, Pearce, David R, Grönroos, Eva, Dive, Caroline, Swanton, Charles

“…Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although advances are being made towards earlier detection and the…”
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Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study by Morrow, C.J., Trapani, F., Metcalf, R.L., Bertolini, G., Hodgkinson, C.L., Khandelwal, G., Kelly, P., Galvin, M., Carter, L., Simpson, K.L., Williamson, S., Wirth, C., Simms, N., Frankliln, L., Frese, K.K., Rothwell, D.G., Nonaka, D., Miller, C.J., Brady, G., Blackhall, F.H., Dive, C.

“…Over the past decade, numerous reports describe the generation and increasing utility of non-small-cell lung cancer (NSCLC) patient-derived xenografts (PDX)…”
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A biobank of small cell lung cancer CDX models elucidates inter- and intratumoral phenotypic heterogeneity by Simpson, Kathryn L, Stoney, Ruth, Frese, Kristopher K, Simms, Nicole, Rowe, William, Pearce, Simon P, Humphrey, Sam, Booth, Laura, Morgan, Derrick, Dynowski, Marek, Trapani, Francesca, Catozzi, Alessia, Revill, Mitchell, Helps, Thomas, Galvin, Melanie, Girard, Luc, Nonaka, Daisuke, Carter, Louise, Krebs, Matthew G, Cook, Natalie, Carter, Mathew, Priest, Lynsey, Kerr, Alastair, Gazdar, Adi F, Blackhall, Fiona, Dive, Caroline

“…Although small cell lung cancer (SCLC) is treated as a homogeneous disease, biopsies and preclinical models reveal heterogeneity in transcriptomes and…”
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