Search Results - "Frere, Justin"
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Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity
Published in Science (American Association for the Advancement of Science) (14-04-2017)“…Zika virus (ZIKV) is spreading rapidly into regions around the world where other flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV), are…”
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SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery
Published in Science translational medicine (28-09-2022)“…The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as…”
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SARS-CoV-2 and Influenza A Virus Induce Longitudinal Transcriptomic Changes in Hamster Spinal Cord Tissue
Published in Spine (Philadelphia, Pa. 1976) (01-03-2024)Get full text
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Psychological distress in the face of a pandemic: An observational study characterizing the impact of COVID-19 on immigrant outpatient mental health
Published in Psychiatry research (01-01-2021)“…•Undocumented immigrant outpatients showed increased depression and anxiety during COVID-19.•The pandemic was directly associated with increased psychological…”
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Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity
Published in Immunity (Cambridge, Mass.) (09-03-2021)“…The emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity, mortality, and societal…”
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Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8 + T Cells in Elderly Humans
Published in The Journal of immunology (1950) (01-02-2022)“…Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously…”
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Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia
Published in Cell (17-03-2022)“…SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe damage in a variety of organs. Thus, deciphering the non-cell-autonomous…”
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Cardiometabolic syndrome — an emergent feature of Long COVID?
Published in Nature reviews. Immunology (01-07-2022)“…Large-scale clinical studies on the post-infectious impacts of SARS-CoV-2 have suggested that patients who have recovered from acute infection have increased…”
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ADAR1 Biology Can Hinder Effective Antiviral RNA Interference
Published in Journal of virology (27-04-2023)“…Viruses constantly evolve and adapt to the antiviral defenses of their hosts. The biology of viral circumvention of these selective pressures can often be…”
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Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy
Published in Immunity (Cambridge, Mass.) (19-03-2019)“…Zika virus (ZIKV) has recently been associated with birth defects and pregnancy loss after maternal infection. Because dengue virus (DENV) and ZIKV…”
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SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model
Published in Science signaling (09-05-2023)“…Although largely confined to the airways, SARS-CoV-2 infection has been associated with sensory abnormalities that manifest in both acute and chronic…”
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Persistent SARS‐CoV‐2 Effects Induce Neuropathy Signature in Dorsal Root Ganglia Underlying Hypersensitivity in a Hamster Model
Published in The FASEB journal (01-05-2022)“…Post‐acute sequelae of COVID‐19, commonly known as long‐COVID, is defined as a persistent symptom(s) that is unexplainable by alternative diagnosis and lasts…”
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Delayed engagement of host defenses enables SARS-CoV-2 viremia and productive infection of distal organs in the hamster model of COVID-19
Published in Science signaling (13-06-2023)“…Clinical presentations that develop in response to infection result from interactions between the pathogen and host defenses. SARS-CoV-2, the etiologic agent…”
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Eosinophil-derived IL-13 promotes emphysema
Published in The European respiratory journal (01-05-2019)“…The inflammatory responses in chronic airway diseases leading to emphysema are not fully defined. We hypothesised that lung eosinophilia contributes to…”
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Respiratory syncytial virus tracking using internet search engine data
Published in BMC public health (03-04-2018)“…Respiratory Syncytial Virus (RSV) is the leading cause of hospitalization in children less than 1 year of age in the United States. Internet search engine…”
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Naïve CD8 + T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8 + T-Cells
Published in Frontiers in immunology (21-12-2018)“…Characterization of the intracellular biochemical processes that regulate the generation and maintenance of effector and memory CD8 T-cells from naïve…”
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Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism Suppression
Published in Biomedicines (28-06-2024)“…Muscle fatigue represents the most prevalent symptom of long-term COVID, with elusive pathogenic mechanisms. We performed a longitudinal study to characterize…”
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Provision of Cognitive Behavior Therapy for Depression and Anxiety Disorders by Medical Student Trainees
Published in Academic psychiatry (01-02-2024)“…Objective The purpose of the article is to evaluate an innovative education program in which medical students were trained in cognitive behavior therapy (CBT)…”
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Viral immunity: Basic mechanisms and therapeutic applications—a Keystone Symposia report
Published in Annals of the New York Academy of Sciences (01-03-2023)“…Viruses infect millions of people each year. Both endemic viruses circulating throughout the population as well as novel epidemic and pandemic viruses pose…”
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Design of and outcomes in a student-run free mental health clinic serving the uninsured in East Harlem
Published in BMC psychiatry (26-07-2022)“…Abstract Background Safety-net clinics are an important source of low-cost or free mental healthcare to those with limited financial resources. Such clinics…”
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