Search Results - "Frenzel, L. P."

Action of novel CD37 antibodies on chronic lymphocytic leukemia cells by Krause, G, Patz, M, Isaeva, P, Wigger, M, Baki, I, Vondey, V, Kerwien, S, Kuckertz, M, Brinker, R, Claasen, J, Frenzel, L P, Wendtner, C-M, Heider, K-H, Hallek, M

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Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies by Thomalla, D., Beckmann, L., Grimm, C., Oliverio, M., Meder, L., Herling, C.D., Nieper, P., Feldmann, T., Merkel, O., Lorsy, E., da Palma Guerreiro, A., von Jan, J., Kisis, I., Wasserburger, E., Claasen, J., Faitschuk-Meyer, E., Altmüller, J., Nürnberg, P., Yang, T.-P., Lienhard, M., Herwig, R., Kreuzer, K.-A., Pallasch, C.P., Büttner, R., Schäfer, S.C., Hartley, J., Abken, H., Peifer, M., Kashkar, H., Knittel, G., Eichhorst, B., Ullrich, R.T., Herling, M., Reinhardt, H.C., Hallek, M., Schweiger, M.R., Frenzel, L.P.

“…•Venetoclax resistance is mediated by methylation and silencing of PUMA.•Treatment algorithms should consider the PUMA, MCL1, and BAX status. [Display omitted]…”
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PHASE 1 STUDY OF PRT1419 (MCL1 INHIBITOR) AS MONOTHERAPY OR IN COMBINATION WITH AZACITIDINE OR VENETOCLAX IN PATIENTS WITH RELAPSED/REFRACTORY MYELOID OR B‐CELL MALIGNANCIES by Zuniga, R. R., Nair, S., Keiffer, G., Ravandi‐Kashani, F., Goldberg, A. D., Traer, E., Frenzel, L. P., Röllig, C., Savickas, G., Sun, W., Atwal, S. K., Hong, W., Assouline, S. E.

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Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemia by Huelsemann, M F, Patz, M, Beckmann, L, Brinkmann, K, Otto, T, Fandrey, J, Becker, H J, Theurich, S, von Bergwelt-Baildon, M, Pallasch, C P, Zahedi, R P, Kashkar, H, Reinhardt, H C, Hallek, M, Wendtner, C M, Frenzel, L P

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Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies by Leskov, I, Pallasch, C P, Drake, A, Iliopoulou, B P, Souza, A, Shen, C-H, Schweighofer, C D, Abruzzo, L, Frenzel, L P, Wendtner, C M, Hemann, M T, Chen, J

“…Although numerous mouse models of B-cell malignancy have been developed via the enforced expression of defined oncogenic lesions, the feasibility of generating…”
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Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors by Riabinska, Arina, Daheim, Mathias, Herter-Sprie, Grit S, Winkler, Johannes, Fritz, Christian, Hallek, Michael, Thomas, Roman K, Kreuzer, Karl-Anton, Frenzel, Lukas P, Monfared, Parisa, Martins-Boucas, Jorge, Chen, Shuhua, Reinhardt, Hans Christian

“…When the integrity of the genome is threatened, cells activate a complex, kinase-based signaling network to arrest the cell cycle, initiate DNA repair, or, if…”
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MP4- and MOG:35–55-induced EAE in C57BL/6 mice differentially targets brain, spinal cord and cerebellum by Kuerten, Stefanie, Kostova-Bales, Dilyana A, Frenzel, Lukas P, Tigno, Justine T, Tary-Lehmann, Magdalena, Angelov, Doychin N, Lehmann, Paul V

“…Abstract Mechanism-oriented studies of EAE rely mostly on gene-modified mice on the C57BL/6 background. Here we report that MP4-induced EAE displays…”
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