Search Results - "Frenkel, Yulia Volovik"

In Search of a Novel Anti-HIV Drug:  Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine) by Janssen, Paul A. J, Lewi, Paul J, Arnold, Eddy, Daeyaert, Frits, de Jonge, Marc, Heeres, Jan, Koymans, Luc, Vinkers, Maarten, Guillemont, Jérôme, Pasquier, Elisabeth, Kukla, Mike, Ludovici, Don, Andries, Koen, de Béthune, Marie-Pierre, Pauwels, Rudi, Das, Kalyan, Clark, Art D, Frenkel, Yulia Volovik, Hughes, Stephen H, Medaer, Bart, De Knaep, Fons, Bohets, Hilde, De Clerck, Fred, Lampo, Ann, Williams, Peter, Stoffels, Paul

“…Ideally, an anti-HIV drug should (1) be highly active against wild-type and mutant HIV without allowing breakthrough; (2) have high oral bioavailability and…”
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Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability by Frenkel, Yulia Volovik, Clark, Arthur D, Das, Kalyan, Wang, Yuh-Hwa, Lewi, Paul J, Janssen, Paul A. J, Arnold, Eddy

“…We have examined selected physicochemical properties of compounds from the diaryltriazine/diarylpyrimidine (DATA/DAPY) classes of non-nucleoside reverse…”
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Molecular Dynamics Study of Non-nucleoside Reverse Transcriptase Inhibitor 4-[[4-[[4-[(E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (TMC278/Rilpivirine) Aggregates: Correlation between Amphiphilic Properties of the Drug and Oral Bioavailability by Volovik Frenkel, Yulia, Gallicchio, Emilio, Das, Kalyan, Levy, Ronald M, Arnold, Eddy

“…The non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278/rilpivirine is an anti-AIDS therapeutic agent with high oral bioavailability despite its high…”
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