Search Results - "Frenguelli, B G"

High‐resolution real‐time recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat hippocampal slices by Frenguelli, B. G., Llaudet, E., Dale, N.

“…We have used improved miniaturized adenosine biosensors to measure adenosine release during hypoxia from within the CA1 region of rat hippocampal slices. These…”
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Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors by Nuritova, F, Frenguelli, B.G

“…Graphical abstract Highlights ► Postsynaptic depolarisation accelerates the hypoxic depression of glutamate release. ► This process is Ca2+ - and PKC-dependent…”
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Differential responses to NMDA receptor activation in rat hippocampal interneurons and pyramidal cells may underlie enhanced pyramidal cell vulnerability by Avignone, E., Frenguelli, B. G., Irving, A. J.

“…Hippocampal interneurons are generally more resistant than pyramidal cells to excitotoxic insults. Because NMDA receptors play a crucial role in…”
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Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells by Ward, Manus W, Rego, A. Cristina, Frenguelli, Bruno G, Nicholls, David G

“…The relationship between changes in mitochondrial membrane potential (Deltapsi(m)) and the failure of cytoplasmic Ca(2+) homeostasis, delayed…”
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Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors by Alford, S, Frenguelli, B G, Schofield, J G, Collingridge, G L

“…1. A combination of confocal microscopy, whole-cell patch-clamp recording, intracellular dialysis and pharmacological techniques have been employed to study…”
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Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase by Diógenes, Maria José, Neves-Tomé, Raquel, Fucile, Sergio, Martinello, Katiuscia, Scianni, Maria, Theofilas, Panos, Lopatár, Jan, Ribeiro, Joaquim A, Maggi, Laura, Frenguelli, Bruno G, Limatola, Cristina, Boison, Detlev, Sebastião, Ana M

“…Extracellular adenosine, a key regulator of neuronal excitability, is metabolized by astrocyte-based enzyme adenosine kinase (ADK). We hypothesized that ADK…”
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The effects of metabolic stress on glutamate receptor-mediated depolarizations in the in vitro rat hippocampal slice by Frenguelli, B.G.

“…A grease-gap preparation for the in vitro rat hippocampal slice has been used to record field excitatory postsynaptic potentials (fEPSPs), extracellular d.c…”
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Differential trafficking of adenosine receptors in hippocampal neurons monitored using GFP- and super-ecliptic pHluorin-tagged receptors by Baines, A.E., Corrêa, S.A.L., Irving, A.J., Frenguelli, B.G.

“…Adenosine receptors (ARs) modulate many cellular and systems-level processes in the mammalian CNS. However, little is known about the trafficking of ARs in…”
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Modulation of native and recombinant GABA A receptors by endogenous and synthetic neuroactive steroids by Lambert, Jeremy J., Belelli, Delia, Harney, Sarah C., Peters, John A., Frenguelli, Bruno G.

“…Upon administration, certain pregnane steroids produce clear behavioural effects including, anxiolysis, sedation, analgesia, anaesthesia and are…”
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Volume-regulated anion channels do not contribute extracellular adenosine during the hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus by Pearson, Tim, Frenguelli, Bruno G.

“…We investigated whether volume‐regulated anion channels (VRACs) contributed to the accumulation of extracellular adenosine during hypoxia in area CA1. The…”
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Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner by Etherington, Lori-An V., Frenguelli, Bruno G.

“…The purine nucleoside adenosine is released during seizure activity and exerts an anticonvulsant influence through inhibition of glutamate release and…”
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Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice by Dale, Nicholas, Pearson, Tim, Frenguelli, Bruno G.

“…We have used an enzyme-based, twin-barrelled sensor to measure adenosine release during hypoxia in the CA1 region of rat hippocampal slices in conjunction with…”
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Metabotropic glutamate receptors and calcium signalling in dendrites of hippocampal CA1 neurones by Frenguelli, B G, Potier, B, Slater, N T, Alford, S, Collingridge, G L

“…We have combined patch-clamp recording with confocal microscopy to investigate how the synaptic activation of metabotropic glutamate receptors (mGluRs) may…”
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Plasticity of purine release during cerebral ischemia: clinical implications? by Pearson, T., Currie, Ailsa J., Etherington, Lori‐An V., Gadalla, Anne E., Damian, Karen, Llaudet, E., Dale, N., Frenguelli, B. G.

“…Adenosine is a powerful modulator of neuronal function in the mammalian central nervous system. During a variety of insults to the brain, adenosine is released…”
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Adrenoceptor subtype-specific acceleration of the hypoxic depression of excitatory synaptic transmission in area CA1 of the rat hippocampus by Pearson, Tim, Frenguelli, Bruno G.

“…The depression of excitatory synaptic transmission by hypoxia in area CA1 of the hippocampus is largely dependent upon the activation of adenosine A1 receptors…”
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A Depletable Pool of Adenosine in Area CA1 of the Rat Hippocampus by Pearson, Tim, Nuritova, Feruza, Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G

“…Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase…”
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Electrogenic uptake contributes a major component of the depolarizing action of l‐glutamate in rat hippocampal slices by Frenguelli, Bruno G., Blake, Joanna F., Brown, Malcolm W., Collingridge, Graham L.

“…1 A grease‐gap technique has been used to measure d.c. potentials, in response to the application of excitatory amino acids and electrical stimulation of the…”
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The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity by Chapman, P F, Frenguelli, B G, Smith, A, Chen, C M, Silva, A J

“…The alpha-Ca2+/calmodulin kinase II (alpha CaMKII) is required for long-term potentiation in the CA1 region of the hippocampus. Here, we report that this…”
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Venom from Anemesia species of spider modulates high voltage-activated Ca(2+) currents from rat cultured sensory neurones and excitatory post synaptic currents from rat hippocampal slices by Kalikulov, D, Ayar, A, Nuritova, F, Frenguelli, B G, McClelland, D, Martin, D J, Davidson, I, Scott, R H

“…The actions of crude venom from Anemesia species of spider were investigated in cultured dorsal root ganglion neurones from neonatal rats and hippocampal…”
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Fluctuations in intracellular calcium responses to action potentials in single en passage presynaptic boutons of layer V neurons in neocortical slices by Frenguelli, B G, Malinow, R

“…The release of neurotransmitter from a nerve terminal on invasion by an action potential shows large trial-to-trial fluctuations. The factors contributing to…”
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