Search Results - "French, Paul M."

Rapid global fitting of large fluorescence lifetime imaging microscopy datasets by Warren, Sean C, Margineanu, Anca, Alibhai, Dominic, Kelly, Douglas J, Talbot, Clifford, Alexandrov, Yuriy, Munro, Ian, Katan, Matilda, Dunsby, Chris, French, Paul M W

“…Fluorescence lifetime imaging (FLIM) is widely applied to obtain quantitative information from fluorescence signals, particularly using Förster Resonant Energy…”
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Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways by Guglielmi, Luca, Heliot, Claire, Kumar, Sunil, Alexandrov, Yuriy, Gori, Ilaria, Papaleonidopoulou, Foteini, Barrington, Christopher, East, Philip, Economou, Andrew D., French, Paul M. W., McGinty, James, Hill, Caroline S.

“…The transcriptional effector SMAD4 is a core component of the TGF-β family signaling pathways. However, its role in vertebrate embryo development remains…”
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Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice by Van de Pette, Mathew, Dimond, Andrew, Galvão, António M., Millership, Steven J., To, Wilson, Prodani, Chiara, McNamara, Gráinne, Bruno, Ludovica, Sardini, Alessandro, Webster, Zoe, McGinty, James, French, Paul M. W., Uren, Anthony G., Castillo-Fernandez, Juan, Watkinson, William, Ferguson-Smith, Anne C., Merkenschlager, Matthias, John, Rosalind M., Kelsey, Gavin, Fisher, Amanda G.

“…Transmission of epigenetic information between generations occurs in nematodes, flies and plants, mediated by specialised small RNA pathways, modified histones…”
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Continuous-Flow Polymerase Chain Reaction of Single-Copy DNA in Microfluidic Microdroplets by Schaerli, Yolanda, Wootton, Robert C, Robinson, Tom, Stein, Viktor, Dunsby, Christopher, Neil, Mark A. A, French, Paul M. W, deMello, Andrew J, Abell, Chris, Hollfelder, Florian

“…We present a high throughput microfluidic device for continuous-flow polymerase chain reaction (PCR) in water-in-oil droplets of nanoliter volumes. The…”
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Structurally Distinct Membrane Nanotubes between Human Macrophages Support Long-Distance Vesicular Traffic or Surfing of Bacteria by Onfelt, Bjorn, Nedvetzki, Shlomo, Benninger, Richard K. P, Purbhoo, Marco A, Sowinski, Stefanie, Hume, Alistair N, Seabra, Miguel C, Neil, Mark A. A, French, Paul M. W, Davis, Daniel M

“…We report that two classes of membrane nanotubes between human monocyte-derived macrophages can be distinguished by their cytoskeletal structure and their…”
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Accelerated Optical Projection Tomography Applied to In Vivo Imaging of Zebrafish by Correia, Teresa, Lockwood, Nicola, Kumar, Sunil, Yin, Jun, Ramel, Marie-Christine, Andrews, Natalie, Katan, Matilda, Bugeon, Laurence, Dallman, Margaret J, McGinty, James, Frankel, Paul, French, Paul M W, Arridge, Simon

“…Optical projection tomography (OPT) provides a non-invasive 3-D imaging modality that can be applied to longitudinal studies of live disease models, including…”
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Multiphoton laser tomography and fluorescence lifetime imaging of melanoma: morphologic features and quantitative data for sensitive and specific non-invasive diagnostics by Seidenari, Stefania, Arginelli, Federica, Dunsby, Christopher, French, Paul M W, König, Karsten, Magnoni, Cristina, Talbot, Clifford, Ponti, Giovanni

“…Multiphoton laser tomography (MPT) combined with fluorescence lifetime imaging (FLIM) is a non-invasive imaging technique, based on the study of fluorescence…”
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Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy by Brown, Alice C N, Oddos, Stephane, Dobbie, Ian M, Alakoskela, Juha-Matti, Parton, Richard M, Eissmann, Philipp, Neil, Mark A A, Dunsby, Christopher, French, Paul M W, Davis, Ilan, Davis, Daniel M

“…Natural Killer (NK) cells are innate immune cells that secrete lytic granules to directly kill virus-infected or transformed cells across an immune synapse…”
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The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice by Georgiadou, Eleni, Haythorne, Elizabeth, Dickerson, Matthew T., Lopez-Noriega, Livia, Pullen, Timothy J., da Silva Xavier, Gabriela, Davis, Samuel P. X., Martinez-Sanchez, Aida, Semplici, Francesca, Rizzuto, Rosario, McGinty, James A., French, Paul M., Cane, Matthew C., Jacobson, David A., Leclerc, Isabelle, Rutter, Guy A.

“…Aims/hypothesis Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). Whether Ca 2+ uptake into pancreatic beta cell…”
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Adaptive phase compensation for ultracompact laser scanning endomicroscopy by Thompson, Alex J, Paterson, Carl, Neil, Mark A A, Dunsby, Chris, French, Paul M W

“…We present an approach to laser scanning endomicroscopy that requires no moving parts and can be implemented with no distal scanners or optics, permitting…”
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Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM) by Margineanu, Anca, Chan, Jia Jia, Kelly, Douglas J., Warren, Sean C., Flatters, Delphine, Kumar, Sunil, Katan, Matilda, Dunsby, Christopher W., French, Paul M. W.

“…We present a high content multiwell plate cell-based assay approach to quantify protein interactions directly in cells using Förster resonance energy transfer…”
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Plasmonic Nanoprobes for Stimulated Emission Depletion Nanoscopy by Cortés, Emiliano, Huidobro, Paloma A, Sinclair, Hugo G, Guldbrand, Stina, Peveler, William J, Davies, Timothy, Parrinello, Simona, Görlitz, Frederik, Dunsby, Chris, Neil, Mark A. A, Sivan, Yonatan, Parkin, Ivan P, French, Paul M. W, Maier, Stefan A

“…Plasmonic nanoparticles influence the absorption and emission processes of nearby emitters due to local enhancements of the illuminating radiation and the…”
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Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse by Purbhoo, Marco A, Liu, Hebin, Oddos, Stephane, Owen, Dylan M, Neil, Mark A A, Pageon, Sophie V, French, Paul M W, Rudd, Christopher E, Davis, Daniel M

“…Imaging studies have identified clusters of kinases and adaptor proteins that serve as centers of signaling at the contact points between T cells and…”
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Multiphoton multispectral fluorescence lifetime tomography for the evaluation of basal cell carcinomas by Patalay, Rakesh, Talbot, Clifford, Alexandrov, Yuriy, Lenz, Martin O, Kumar, Sunil, Warren, Sean, Munro, Ian, Neil, Mark A A, König, Karsten, French, Paul M W, Chu, Anthony, Stamp, Gordon W H, Dunsby, Chris

“…We present the first detailed study using multispectral multiphoton fluorescence lifetime imaging to differentiate basal cell carcinoma cells (BCCs) from…”
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Robust deep learning optical autofocus system applied to automated multiwell plate single molecule localization microscopy by Lightley, Jonathan, Görlitz, Frederik, Kumar, Sunil, Kalita, Ranjan, Kolbeinsson, Arinbjorn, Garcia, Edwin, Alexandrov, Yuriy, Bousgouni, Vicky, Wysoczanski, Riccardo, Barnes, Peter, Donnelly, Louise, Bakal, Chris, Dunsby, Christopher, Neil, Mark A.A., Flaxman, Seth, French, Paul M.W.

“…We presenta robust, long‐range optical autofocus system for microscopy utilizing machine learning. This can be useful for experiments with long image data…”
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Analysis of DNA Binding and Nucleotide Flipping Kinetics Using Two-Color Two-Photon Fluorescence Lifetime Imaging Microscopy by Robinson, Tom, Valluri, Prashant, Kennedy, Gordon, Sardini, Alessandro, Dunsby, Christopher, Neil, Mark A. A, Baldwin, Geoff S, French, Paul M. W, de Mello, Andrew J

“…Uracil DNA glycosylase plays a key role in DNA maintenance via base excision repair. Its role is to bind to DNA, locate unwanted uracil, and remove it using a…”
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The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide‑1 Receptor Biased Agonists by Fang, Zijian, Chen, Shiqian, Pickford, Philip, Broichhagen, Johannes, Hodson, David J, Corrêa, Ivan R, Kumar, Sunil, Görlitz, Frederik, Dunsby, Chris, French, Paul M. W, Rutter, Guy A, Tan, Tricia, Bloom, Stephen R, Tomas, Alejandra, Jones, Ben

“…Signal bias and membrane trafficking have recently emerged as important considerations in the therapeutic targeting of the glucagon-like peptide-1 receptor…”
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Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition by Gleneadie, Hannah J., Fernandez-Ruiz, Beatriz, Sardini, Alessandro, Van de Pette, Mathew, Dimond, Andrew, Prinjha, Rab K., McGinty, James, French, Paul M. W., Bagci, Hakan, Merkenschlager, Matthias, Fisher, Amanda G.

“…Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by loss of function mutations in the dystrophin gene ( Dmd ), resulting in progressive muscle…”
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Homo-FRET Based Biosensors and Their Application to Multiplexed Imaging of Signalling Events in Live Cells by Warren, Sean C, Margineanu, Anca, Katan, Matilda, Dunsby, Chris, French, Paul M W

“…Multiplexed imaging of Förster Resonance Energy Transfer (FRET)-based biosensors potentially presents a powerful approach to monitoring the spatio-temporal…”
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In vivo label-free mapping of the effect of a photosystem II inhibiting herbicide in plants using chlorophyll fluorescence lifetime by Noble, Elizabeth, Kumar, Sunil, Görlitz, Frederik G, Stain, Chris, Dunsby, Chris, French, Paul M W

“…In order to better understand and improve the mode of action of agrochemicals, it is useful to be able to visualize their uptake and distribution in vivo,…”
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