Search Results - "French, P. M."

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice by da Silva Xavier, G., Mondragon, A., Sun, G., Chen, L., McGinty, J. A., French, P. M., Rutter, G. A.

“…Aims/hypothesis Individuals carrying type 2 diabetes risk alleles in TCF7L2 display decreased beta cell levels of T cell factor 7 like-2 (TCF7L2)…”
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SUMOylation inhibits FOXM1 activity and delays mitotic transition by Myatt, S S, Kongsema, M, Man, C W-Y, Kelly, D J, Gomes, A R, Khongkow, P, Karunarathna, U, Zona, S, Langer, J K, Dunsby, C W, Coombes, R C, French, P M, Brosens, J J, Lam, E W-F

“…The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently…”
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Fluorescence lifetime tomography of live cells expressing enhanced green fluorescent protein embedded in a scattering medium exhibiting background autofluorescence by Soloviev, Vadim Y, McGinty, James, Tahir, Khadija B, Neil, Mark A, Sardini, Alessandro, Hajnal, Joseph V, Arridge, Simon R, French, P M

“…We present a novel fluorescence lifetime tomography system applied to a highly scattering autofluorescent phantom containing live cells expressing the…”
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High-speed wide-field time-gated endoscopic fluorescence-lifetime imaging by Requejo-Isidro, J, McGinty, J, Munro, I, Elson, D S, Galletly, N P, Lever, M J, Neil, M A A, Stamp, G W H, French, P M W, Kellett, P A, Hares, J D, Dymoke-Bradshaw, A K L

“…We report the development of a high-speed wide-field fluorescence-lifetime imaging (FLIM) system that provides fluorescence-lifetime images at rates of as many…”
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Toward the clinical application of time-domain fluorescence lifetime imaging by Munro, I, McGinty, J, Galletly, N, Requejo-Isidro, J, Lanigan, P M P, Elson, D S, Dunsby, C, Neil, M A A, Lever, M J, Stamp, G W H, French, P M W

“…High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope is reported based on gated optical image intensifier technology. The…”
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Multifocal multiphoton excitation and time correlated single photon counting detection for 3-D fluorescence lifetime imaging by Kumar, S, Dunsby, C, De Beule, P A A, Owen, D M, Anand, U, Lanigan, P M P, Benninger, R K P, Davis, D M, Neil, M A A, Anand, P, Benham, C, Naylor, A, French, P M W

“…We report a multifocal multiphoton time-correlated single photon counting (TCSPC) fluorescence lifetime imaging (FLIM) microscope system that uses a 16 channel…”
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openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation by Lightley, J, Kumar, S, Lim, M Q, Garcia, E, Görlitz, F, Alexandrov, Y, Parrado, T, Hollick, C, Steele, E, Roßmann, K, Graham, J, Broichhagen, J, McNeish, I A, Roufosse, C A, Neil, M A A, Dunsby, C, French, P M W

“…'openFrame' is a modular, low-cost, open-hardware microscopy platform that can be configured or adapted to most light microscopy techniques and is easily…”
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Accelerating single molecule localization microscopy through parallel processing on a high‐performance computing cluster by MUNRO, I., GARCÍA, E., YAN, M., GULDBRAND, S., KUMAR, S., KWAKWA, K., DUNSBY, C., NEIL, M.A.A., FRENCH, P.M.W.

“…Summary Super‐resolved microscopy techniques have revolutionized the ability to study biological structures below the diffraction limit. Single molecule…”
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Imaging fluorescence lifetime heterogeneity applied to GFP‐tagged MHC protein at an immunological synapse by TREANOR, B., LANIGAN, P. M. P., SUHLING, K., SCHREIBER, T., MUNRO, I., NEIL, M. A. A., PHILLIPS, D., DAVIS, D. M., FRENCH, P. M. W.

“…Summary Fluorescence imaging of green fluorescent protein (GFP) may be used to locate proteins in live cells and fluorescence lifetime imaging (FLIM) may be…”
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Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo by Sun, G., Tarasov, A. I., McGinty, J., McDonald, A., da Silva Xavier, G., Gorman, T., Marley, A., French, P. M., Parker, H., Gribble, F., Reimann, F., Prendiville, O., Carzaniga, R., Viollet, B., Leclerc, I., Rutter, G. A.

“…Aims/hypothesis AMP-activated protein kinase (AMPK) is an evolutionarily conserved enzyme and a target of glucose-lowering agents, including metformin…”
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Ablation of AMP-activated protein kinase alpha 1 and alpha 2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo by Sun, G, Tarasov, AI, McGinty, J, McDonald, A, Silva Xavier, G, Gorman, T, Marley, A, French, P M, Parker, H, Gribble, F, Reimann, F, Prendiville, O, Carzaniga, R, Viollet, B, Leclerc, I, Rutter, G A

“…Aims/hypothesis: AMP-activated protein kinase (AMPK) is an evolutionarily conserved enzyme and a target of glucose-lowering agents, including metformin…”
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Fluorescence lifetime imaging distinguishes basal cell carcinoma from surrounding uninvolved skin by Galletly, N.P., McGinty, J., Dunsby, C., Teixeira, F., Requejo‐Isidro, J., Munro, I., Elson, D.S., Neil, M.A.A., Chu, A.C., French, P.M.W., Stamp, G.W.

“…Summary Background  Fluorescence lifetime imaging (FLIM) is a novel imaging technique that generates image contrast between different states of tissue due to…”
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A hyperspectral fluorescence lifetime probe for skin cancer diagnosis by De Beule, P A A, Dunsby, C, Galletly, N P, Stamp, G W, Chu, A C, Anand, U, Anand, P, Benham, C D, Naylor, A, French, P M W

“…The autofluorescence of biological tissue can be exploited for the detection and diagnosis of disease but, to date, its complex nature and relatively weak…”
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Matrix-Addressable Micropixellated InGaN Light-Emitting Diodes With Uniform Emission and Increased Light Output by Gong, Z., Zhang, H.X., Gu, E., Griffin, C., Dawson, M.D., Poher, V., Kennedy, G., French, P.M.W., Neil, M.A.A.

“…Micropixellated InGaN light-emitting diodes (micro- LEDs) have a wide number of potential applications in areas including microdisplays, fluorescence-based…”
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High speed optically sectioned fluorescence lifetime imaging permits study of live cell signaling events by Grant, David M, McGinty, J, McGhee, E J, Bunney, T D, Owen, D M, Talbot, C B, Zhang, W, Kumar, S, Munro, I, Lanigan, P M, Kennedy, G T, Dunsby, C, Magee, A I, Courtney, P, Katan, M, Neil, M A A, French, P M W

“…We present a time domain optically sectioned fluorescence lifetime imaging (FLIM) microscope developed for high-speed live cell imaging. This single photon…”
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Optical sectioning microscopes with no moving parts using a micro-stripe array light emitting diode by Poher, V, Zhang, H X, Kennedy, G T, Griffin, C, Oddos, S, Gu, E, Elson, D S, Girkin, M, French, P M W, Dawson, M D, Neil, M A

“…We describe an optical sectioning microscopy system with no moving parts based on a micro-structured stripe-array light emitting diode (LED). By projecting…”
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Existence of electronic excitation enhanced crystallization in GeSb amorphous thin films upon ultrashort laser pulse irradiation by Solis, J, Afonso, CN, Hyde, SC, Barry, NP, French, PM

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Time‐domain whole‐field fluorescence lifetime imaging with optical sectioning by Cole, M. J., Siegel, J., Webb, S. E. D., Jones, R., Dowling, K., Dayel, M. J., Parsons‐Karavassilis, D., French, P. M. W., Lever, M. J., Sucharov, L. O. D., Neil, M. A. A., Juškaitis, R., Wilson, T.

“…A whole‐field time‐domain fluorescence lifetime imaging (FLIM) microscope with the capability to perform optical sectioning is described. The excitation source…”
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Spatially selective sampling of single cells using optically trapped fusogenic emulsion droplets: a new single-cell proteomic tool by Lanigan, Peter M.P, Chan, Karen, Ninkovic, Tanya, Templer, Richard H, French, P.M.W, de Mello, A.J, Willison, K.R, Parker, P.J, Neil, M.A.A, Ces, Oscar, Klug, D.R

“…-glycero-3-phosphatidylcholine) were brought into controlled contact with target colon cancer cells leading to the formation of connecting membrane tethers…”
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Spatially resolved electric fields in polymer light-emitting diodes using fluorescence lifetime imaging by Koeberg, M., Elson, D.S., French, P.M.W., Bradley, D.D.C.

“…Polymer light-emitting diode (LED) structures have been studied using fluorescence lifetime imaging (FLIM). FLIM allows one to image perturbations in the…”
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