Search Results - "French, Deborah"

Clinical utility of laboratory developed mass spectrometry assays for steroid hormone testing by French, Deborah

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Development and validation of a serum total testosterone liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay calibrated to NIST SRM 971 by French, Deborah

“…At our institution, serum testosterone in adult males is measured by immunoassay while female and pediatric specimens are sent to a reference laboratory for…”
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Understanding platelet generation from megakaryocytes: implications for in vitro–derived platelets by Sim, Xiuli, Poncz, Mortimer, Gadue, Paul, French, Deborah L.

“…Platelets are anucleate cytoplasmic discs derived from megakaryocytes that circulate in the blood and have major roles in hemostasis, thrombosis, inflammation,…”
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The challenges of LC-MS/MS analysis of opiates and opioids in urine by French, Deborah

“…Opioids are some of the most commonly prescribed and abused drugs around the world. Primarily used for anesthesia or pain management, other opioids can also be…”
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Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells by Mukherjee, Somdutta, French, Deborah L., Gadue, Paul

“…Tbx3 has been identified as a regulator of liver development in the mouse, but its function in human liver development remains unknown. TBX3 mutant human…”
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Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages by Ditadi, Andrea, Sturgeon, Christopher M., Tober, Joanna, Awong, Geneve, Kennedy, Marion, Yzaguirre, Amanda D., Azzola, Lisa, Ng, Elizabeth S., Stanley, Edouard G., French, Deborah L., Cheng, Xin, Gadue, Paul, Speck, Nancy A., Elefanty, Andrew G., Keller, Gordon

“…The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) will depend on the accurate recapitulation of embryonic…”
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A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders by Simeoni, Ilenia, Stephens, Jonathan C., Hu, Fengyuan, Deevi, Sri V.V., Megy, Karyn, Bariana, Tadbir K., Lentaigne, Claire, Schulman, Sol, Sivapalaratnam, Suthesh, Vries, Minka J.A., Westbury, Sarah K., Greene, Daniel, Papadia, Sofia, Alessi, Marie-Christine, Attwood, Antony P., Ballmaier, Matthias, Baynam, Gareth, Bermejo, Emilse, Bertoli, Marta, Bray, Paul F., Bury, Loredana, Cattaneo, Marco, Collins, Peter, Daugherty, Louise C., Favier, Rémi, French, Deborah L., Furie, Bruce, Gattens, Michael, Germeshausen, Manuela, Ghevaert, Cedric, Goodeve, Anne C., Guerrero, Jose A., Hampshire, Daniel J., Hart, Daniel P., Heemskerk, Johan W.M., Henskens, Yvonne M.C., Hill, Marian, Hogg, Nancy, Jolley, Jennifer D., Kahr, Walter H., Kelly, Anne M., Kerr, Ron, Kostadima, Myrto, Kunishima, Shinji, Lambert, Michele P., Liesner, Ri, López, José A., Mapeta, Rutendo P., Mathias, Mary, Millar, Carolyn M., Nathwani, Amit, Neerman-Arbez, Marguerite, Nurden, Alan T., Nurden, Paquita, Othman, Maha, Peerlinck, Kathelijne, Perry, David J., Poudel, Pawan, Reitsma, Pieter, Rondina, Matthew T., Smethurst, Peter A., Stevenson, William, Szkotak, Artur, Tuna, Salih, van Geet, Christel, Whitehorn, Deborah, Wilcox, David A., Zhang, Bin, Revel-Vilk, Shoshana, Gresele, Paolo, Bellissimo, Daniel B., Penkett, Christopher J., Laffan, Michael A., Mumford, Andrew D., Rendon, Augusto, Gomez, Keith, Freson, Kathleen, Ouwehand, Willem H., Turro, Ernest

“…Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia…”
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Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications by Borst, Sara, Sim, Xiuli, Poncz, Mortimer, French, Deborah L, Gadue, Paul

“…Platelets, derived from megakaryocytes, are anucleate cytoplasmic discs that circulate in the blood stream and play major roles in hemostasis, inflammation,…”
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PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes by Wickramasinghe, Nadeera M., Sachs, David, Shewale, Bhavana, Gonzalez, David M., Dhanan-Krishnan, Priyanka, Torre, Denis, LaMarca, Elizabeth, Raimo, Serena, Dariolli, Rafael, Serasinghe, Madhavika N., Mayourian, Joshua, Sebra, Robert, Beaumont, Kristin, Iyengar, Srinivas, French, Deborah L., Hansen, Arne, Eschenhagen, Thomas, Chipuk, Jerry E., Sobie, Eric A., Jacobs, Adam, Akbarian, Schahram, Ischiropoulos, Harry, Ma’ayan, Avi, Houten, Sander M., Costa, Kevin, Dubois, Nicole C.

“…Pluripotent stem-cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented opportunity to study human heart development and disease, but they are…”
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Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia by Antony-Debré, Iléana, Manchev, Vladimir T., Balayn, Nathalie, Bluteau, Dominique, Tomowiak, Cécile, Legrand, Céline, Langlois, Thierry, Bawa, Olivia, Tosca, Lucie, Tachdjian, Gérard, Leheup, Bruno, Debili, Najet, Plo, Isabelle, Mills, Jason A., French, Deborah L., Weiss, Mitchell J., Solary, Eric, Favier, Remi, Vainchenker, William, Raslova, Hana

“…To explore how RUNX1 mutations predispose to leukemia, we generated induced pluripotent stem cells (iPSCs) from 2 pedigrees with germline RUNX1 mutations. The…”
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Genome Engineering Human ESCs or iPSCs with Cytosine and Adenine Base Editors by Pavani, Giulia, Klein, Joshua G, French, Deborah L, Gadue, Paul

“…The ability to engineer specific mutations in human embryonic stem cells (ECSs) or induced pluripotent stem cells (iPSCs) is extremely important in the…”
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Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells by Giani, Felix C., Fiorini, Claudia, Wakabayashi, Aoi, Ludwig, Leif S., Salem, Rany M., Jobaliya, Chintan D., Regan, Stephanie N., Ulirsch, Jacob C., Liang, Ge, Steinberg-Shemer, Orna, Guo, Michael H., Esko, Tõnu, Tong, Wei, Brugnara, Carlo, Hirschhorn, Joel N., Weiss, Mitchell J., Zon, Leonard I., Chou, Stella T., French, Deborah L., Musunuru, Kiran, Sankaran, Vijay G.

“…Multipotent and pluripotent stem cells are potential sources for cell and tissue replacement therapies. For example, stem cell-derived red blood cells (RBCs)…”
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Mutation-specific signaling profiles and kinase inhibitor sensitivities of juvenile myelomonocytic leukemia revealed by induced pluripotent stem cells by Tasian, Sarah K., Casas, Jessica A., Posocco, David, Gandre-Babbe, Shilpa, Gagne, Alyssa L., Liang, Ge, Loh, Mignon L., Weiss, Mitchell J., French, Deborah L., Chou, Stella T.

“…Juvenile myelomonocytic leukemia (JMML) is an uncommon myeloproliferative neoplasm driven by Ras pathway mutations and hyperactive Ras/MAPK signaling. Outcomes…”
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Challenges and promises for the development of donor-independent platelet transfusions by Lambert, Michele P., Sullivan, Spencer K., Fuentes, Rudy, French, Deborah L., Poncz, Mortimer

“…Platelet transfusions are often a life-saving intervention, and the use of platelet transfusions has been increasing. Donor-derived platelet availability can…”
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p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation by Campbell, Clyde A., Calderon, Rodolfo, Pavani, Giulia, Cheng, Xiaoyi, Barakat, Radwa, Snella, Elizabeth, Liu, Fang, Peng, Xiyu, Essner, Jeffrey J., Dorman, Karin S., McGrail, Maura, Gadue, Paul, French, Deborah L., Espin-Palazon, Raquel

“…Most gene functions have been discovered through phenotypic observations under loss of function experiments that lack temporal control. However, cell signaling…”
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Generation of Transgene‐Free Lung Disease‐Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette by Somers, Aba, Jean, Jyh‐Chang, Sommer, Cesar A., Omari, Amel, Ford, Christopher C., Mills, Jason A., Ying, Lei, Sommer, Andreia Gianotti, Jean, Jenny M., Smith, Brenden W., Lafyatis, Robert, Demierre, Marie‐France, Weiss, Daniel J., French, Deborah L., Gadue, Paul, Murphy, George J., Mostoslavsky, Gustavo, Kotton, Darrell N.

“…The development of methods to achieve efficient reprogramming of human cells while avoiding the permanent presence of reprogramming transgenes represents a…”
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Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A by Cardenas-Diaz, Fabian L., Osorio-Quintero, Catherine, Diaz-Miranda, Maria A., Kishore, Siddharth, Leavens, Karla, Jobaliya, Chintan, Stanescu, Diana, Ortiz-Gonzalez, Xilma, Yoon, Christine, Chen, Christopher S., Haliyur, Rachana, Brissova, Marcela, Powers, Alvin C., French, Deborah L., Gadue, Paul

“…Human monogenic diabetes, caused by mutations in genes involved in beta cell development and function, has been a challenge to study because multiple mouse…”
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Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases by Cheng, Xiaoyi, Barakat, Radwa, Pavani, Giulia, Usha, Masuma Khatun, Calderon, Rodolfo, Snella, Elizabeth, Gorden, Abigail, Zhang, Yudi, Gadue, Paul, French, Deborah L., Dorman, Karin S., Fidanza, Antonella, Campbell, Clyde A., Espin-Palazon, Raquel

“…Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to hematopoietic stem and progenitor cell…”
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Modeling genetic platelet disorders with human pluripotent stem cells: mega-progress but wanting more on our plate(let) by Nations, Catriana C., Pavani, Giulia, French, Deborah L., Gadue, Paul

“…Megakaryocytes are rare hematopoietic cells that play an instrumental role in hemostasis, and other important biological processes such as immunity and wound…”
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The use of pluripotent stem cells to generate diagnostic tools for transfusion medicine by An, Hyun Hyung, Gagne, Alyssa L., Maguire, Jean Ann, Pavani, Giulia, Abdulmalik, Osheiza, Gadue, Paul, French, Deborah L., Westhoff, Connie M., Chou, Stella T.

“…•Human iPSC reprogramming and gene editing can be combined to generate an alternative source of rare RBCs.•Rh-engineered iPSC-derived RBCs provide a novel tool…”
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