Search Results - "French, A B"

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution by Prasad, K-M R, Xu, Y, Yang, Z, Acton, S T, French, B A

“…Newly isolated serotypes of AAV readily cross the endothelial barrier to provide efficient transgene delivery throughout the body. However, tissue-specific…”
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Systemic injection of AAV9 carrying a periostin promoter targets gene expression to a myofibroblast-like lineage in mouse hearts after reperfused myocardial infarction by Piras, B A, Tian, Y, Xu, Y, Thomas, N A, O'Connor, D M, French, B A

“…Adeno-associated virus (AAV) has been used to direct gene transfer to a variety of tissues, including heart, liver, skeletal muscle, brain, kidney and lung,…”
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Over expression of proteins that alter the intracellular signaling pathways in the cytoplasm of the liver cells forming Mallory-Denk bodies by Afifiyan, N., Tillman, B., French, B.A., Masouminia, M., Samadzadeh, S., French, S.W.

“…In this study, liver biopsy sections fixed in formalin and embedded in paraffin (FFPE) from patients with alcoholic hepatitis (AH) were used. The results…”
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FAT10 knock out mice livers fail to develop Mallory–Denk bodies in the DDC mouse model by French, S.W., French, B.A., Oliva, J., Li, J., Bardag-Gorce, F., Tillman, B., Canaan, A.

“…Mallory–Denk bodies (MDBs) are aggresomes composed of undigested ubiqutinated short lived proteins which have accumulated because of a decrease in the rate of…”
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Mallory–Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells by French, B.A., Oliva, J., Bardag-Gorce, F., Li, J., Zhong, J., Buslon, V., French, S.W.

“…EZH2/H3K27me3 and polycomb group complex (PcG) play a major role in regulating global gene expression including tumor suppressor genes. EZH2 is linked to cell…”
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Upregulation of autophagy components in alcoholic hepatitis and nonalcoholic steatohepatitis by Masouminia, M., Samadzadeh, S., Mendoza, A.S., French, B.A., Tillman, B., French, S.W.

“…There are many homeostatic mechanisms for coping with stress conditions in cells, including autophagy. In many studies autophagy, as an intracellular pathway…”
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The role of innate immunity in the pathogenesis of preneoplasia in drug-induced chronic hepatitis based on a mouse model by French, S.W., Bardag-Gorce, F., French, B.A., Li, J., Oliva, J.

“…Innate immunity factors such as conversion of the 26S proteasome to form the immunoproteasome and the Toll-like receptor signaling pathways are activated in…”
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The cyclic pattern of blood alcohol levels during continuous ethanol feeding in rats The effect of feeding S-adenosylmethionine by BARDAG-GORCE, F, LI, J, OLIVA, J, LU, S. C, FRENCH, B. A, FRENCH, S. W

“…S-adenosylmethionine (SAMe), the major methyl donor for DNA and histone methylation was fed with ethanol for 1month in order to modify the effects of ethanol…”
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Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo by Agah, R, Frenkel, P A, French, B A, Michael, L H, Overbeek, P A, Schneider, M D

“…Mouse models of human disease can be generated by homologous recombination for germline loss-of-function mutations. However, embryonic-lethal phenotypes and…”
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Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1 month using the rat intragastric tube feeding model by Li, J., Li, X.M., Caudill, M., Malysheva, O., Bardag-Gorce, F., Oliva, J., French, B.A., Gorce, E., Morgan, K., Kathirvel, E., Morgan, T., French, S.W.

“…Blood alcohol levels (BAL) cycle up and down over a 7–8 day period when ethanol is fed continuously for one month in the intragastric tube feeding rat model…”
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Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections by Buzzanco, A., Gomez, A., Rodriguez, E., French, B.A., Tillman, B.A., Chang, S., Ganapathy, E., Junrungsee, S., Zarrinpar, A., Agopian, V.G., Naini, B.V., French, S.W., French, S.W.

“…The most common type of liver cancer, hepatocellular carcinoma (HCC), affects over 500,000 people in the world. In the present study, liver tumor resections…”
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Nitric Oxide Donors Induce Late Preconditioning Against Myocardial Stunning and Infarction in Conscious Rabbits via an Antioxidant-Sensitive Mechanism by Takano, Hitoshi, Tang, Xian-Liang, Qiu, Yumin, Guo, Yiru, French, Brent A, Bolli, Roberto

“…The goal of this study was to test the hypothesis that the cardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked by…”
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The role of stem cells/progenitor cells in liver carcinogenesis in glycine N-methyltransferase deficient mice by Martinez-Chantar, M.L., Lu, S.C., Mato, J.M., Luka, Z., Wagner, C., French, B.A., French, S.W.

“…Regeneration of the liver is inhibited as a result of a sustained increase in S-adenosylmethionine levels in glycine N-methyltransferase (GNMT)−/− mice. This…”
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The effect of propranolol on gene expression during the blood alcohol cycle of rats fed ethanol intragastrically by Li, J., Bardag-Gorce, F., Oliva, J., French, B.A., Dedes, J., French, S.W.

“…Propranolol, a beta adrenergic blocker prevents the blood alcohol (BAL) cycle in rats fed ethanol intragastrically at a constant rate by preventing the cyclic…”
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The role of the IL-8 signaling pathway in the infiltration of granulocytes into the livers of patients with alcoholic hepatitis by French, S.W., Mendoza, A.S., Afifiyan, N., Tillman, B., Vitocruz, E., French, B.A.

“…IL-8 (C-X-L motif chemokine ligase 8) and CXCR2 (C-X-C-motif chemokine receptor 2) are up regulated in alcoholic hepatitis (AH) liver biopsies. One of the…”
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Ufmylation and FATylation pathways are downregulated in human alcoholic and nonalcoholic steatohepatitis, and mice fed DDC, where Mallory–Denk bodies (MDBs) form by Liu, H., Li, J., Tillman, B., French, B.A., French, S.W.

“…We previously reported the mechanisms involved in the formation of Mallory–Denk bodies (MDBs) in mice fed DDC. To further provide clinical evidence as to how…”
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Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors by FRENCH, B. A, MAZUR, M, GESKE, R. S, BOLLI, R

“…Efficient methods of introducing genes into myocardial cells must be developed before local somatic cell gene therapy can be implemented against myocardial…”
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Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery by Katwal, A B, Konkalmatt, P R, Piras, B A, Hazarika, S, Li, S S, John Lye, R, Sanders, J M, Ferrante, E A, Yan, Z, Annex, B H, French, B A

“…Targeting therapeutic gene expression to the skeletal muscle following intravenous (IV) administration is an attractive strategy for treating peripheral…”
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The role of Tec kinase signaling pathways in the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis by Afifiyan, N., Tillman, B., French, B.A., Sweeny, O., Masouminia, M., Samadzadeh, S., French, S.W.

“…Several research strategies have been used to study the pathogenesis of alcoholic hepatitis (AH). These strategies have shown that various signaling pathways…”
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The effect of Viagra (sildenafil citrate) on liver injury caused by chronic ethanol intragastric feeding in rats by Li, J., Fu, P., DeLeon, M., French, B.A., French, S.W.

“…Rats fed with ethanol and a nutritious diet intragastrically develop liver pathologic changes associated with cyclic elevation of blood and urinary ethanol…”
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