Search Results - "Fremont, D H"

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides by Fremont, Daved H., Hendrickson, Wayne A., Marrack, Philippa, Kappler, John

“…The high-resolution x-ray crystal structures of the murine major histocompatibility complex (MHC) class II molecule, I-E$^k$, occupied by either of two…”
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Tumour necrosis factor superfamily cytokines and the pathogenesis of inflammatory osteolysis by Lam, J, Abu-Amer, Y, Nelson, C A, Fremont, D H, Ross, F P, Teitelbaum, S L

“…The means by which the osteoclast degrades bone involves its attachment to the target matrix, an event involving the αvβ3 integrin. 2 Once cell/matrix…”
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Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules by Matsumura, Masazumi, Fremont, Daved H., Peterson, Per A., Wilson, Ian A.

“…Class I major histocompatibility complex (MHC) molecules interact with self and foreign peptides of diverse amino acid sequences yet exhibit distinct…”
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Structural and Functional Consequences of Altering a Peptide MHC Anchor Residue by Kersh, Gilbert J, Miley, Michael J, Nelson, Christopher A, Grakoui, Arash, Horvath, Stephen, Donermeyer, David L, Kappler, John, Allen, Paul M, Fremont, Daved H

“…To better understand TCR discrimination of multiple ligands, we have analyzed the crystal structures of two Hb peptide/I-E(k) complexes that differ by only a…”
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Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus by Diamond, Michael S, Oliphant, Theodore, Engle, Michael, Nybakken, Grant E, Doane, Chris, Johnson, Syd, Huang, Ling, Gorlatov, Sergey, Mehlhop, Erin, Marri, Anantha, Chung, Kyung Min, Ebel, Gregory D, Kramer, Laura D, Fremont, Daved H

“…Neutralization of West Nile virus (WNV) in vivo correlates with the development of an antibody response against the viral envelope (E) protein. Using random…”
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Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors by Yokoyama, Wayne M, Iizuka, Koho, Naidenko, Olga V, Plougastel, Beatrice F M, Fremont, Daved H

“…The natural killer (NK) gene complex (NKC) encodes orphan lectin-like NK cell receptors that may explain uncharacterized NK cell specificities. Unlike other…”
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Recognition of a Virus-Encoded Ligand by a Natural Killer Cell Activation Receptor by Hamish R. C. Smith, Heusel, Jonathan W., Mehta, Indira K., Kim, Sungjin, Dorner, Brigitte G., Naidenko, Olga V., Iizuka, Koho, Furukawa, Hiroshi, Beckman, Diana L., Pingel, Jeanette T., Scalzo, Anthony A., Fremont, Daved H., Yokoyama, Wayne M.

“…Natural killer (NK) cells express inhibitory and activation receptors that recognize MHC class I-like molecules on target cells. These receptors may be…”
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Structure and Intracellular Targeting of the SARS-Coronavirus Orf7a Accessory Protein by Nelson, Christopher A., Pekosz, Andrew, Lee, Chung A., Diamond, Michael S., Fremont, Daved H.

“…The open reading frame (ORF) 7a of the SARS-associated coronavirus (SARS-CoV) encodes a unique type I transmembrane protein of unknown function. We have…”
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Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association by FREMONT, D. H, ANDERSON, D. H, WILSON, I. A, DENNIS, E. A, NGUYEN-HUU XUONG

“…Phospholipase A2 (PLA2) from Indian cobra venom (Naja naja naja) was crystallized from ethanol in space group P4(3)2(1)2 in the presence of Ca2+. The x-ray…”
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High- and Low-Potency Ligands with Similar Affinities for the TCR: The Importance of Kinetics in TCR Signaling by Kersh, Gilbert J, Kersh, Ellen N, Fremont, Daved H, Allen, Paul M

“…We have examined binding characteristics for a single TCR interacting with five of its different peptide/MHC ligands using surface plasmon resonance. We find…”
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Structural basis of cytochrome c presentation by IE(k) by Fremont, Daved H, Dai, Shaodong, Chiang, Herbert, Crawford, Frances, Marrack, Philippa, Kappler, John

“…The COOH-terminal peptides of pigeon and moth cytochrome c, bound to mouse IE(k), are two of the most thoroughly studied T cell antigens. We have solved the…”
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N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation by Murphy, Kenneth M, Ota, Naruhisa, Brett, Tom J, Murphy, Theresa L, Fremont, Daved H

“…The N-terminal protein interaction domain (N-domain) of the signal transducer and activator of transcription-4 (STAT4) is believed to stabilize interactions…”
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Biochemical Features of the MHC-Related Protein 1 Consistent with an Immunological Function by Miley, Michael J, Truscott, Steven M, Yu, Yik Yeung Lawrence, Gilfillan, Susan, Fremont, Daved H, Hansen, Ted H, Lybarger, Lonnie

“…MHC-related protein (MR)1 is an MHC class I-related molecule encoded on chromosome 1 that is highly conserved among mammals and is more closely related to…”
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Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice by Latek, R R, Suri, A, Petzold, S J, Nelson, C A, Kanagawa, O, Unanue, E R, Fremont, D H

“…We have determined the crystal structure of I-Ag7, an integral component in murine type I diabetes development. Several features distinguish I-Ag7 from other…”
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Identification of a Gammaherpesvirus Selective Chemokine Binding Protein That Inhibits Chemokine Action by van Berkel, V, Barrett, J, Tiffany, H L, Fremont, D H, Murphy, P M, McFadden, G, Speck, S H, Virgin HW, I V

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Crystal Structure of the α Appendage of AP-2 Reveals a Recruitment Platform for Clathrin-Coat Assembly by Traub, Linton M., Downs, Maureen A., Westrich, Jennifer L., Fremont, Daved H.

“…AP-2 adaptors regulate clathrin-bud formation at the cell surface by recruiting clathrin trimers to the plasma membrane and by selecting certain membrane…”
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Structural Basis of Chemokine Sequestration by a Herpesvirus Decoy Receptor by Alexander, Jennifer M., Nelson, Christopher A., van Berkel, Victor, Lau, Elaine K., Studts, Joey M., Brett, Tom J., Speck, Samuel H., Handel, Tracy M., Virgin, Herbert W., Fremont, Daved H.

“…The M3 protein encoded by murine γherpesvirus68 (γHV68) functions as an immune system saboteur by the engagement of chemoattractant cytokines, thereby altering…”
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The role of mhc polymorphism in anti-microbial resistance by Nikolich-Žugich, Janko, Fremont, Daved H, Miley, Michael J, Messaoudi, Ilhem

“…The major histocompatibility complex ( mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life…”
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Crystallization of murine major histocompatibility complex class I H-2Kb with single peptides by Stura, E A, Matsumura, M, Fremont, D H, Saito, Y, Peterson, P A, Wilson, I A

“…X-ray quality crystals of a soluble murine class I H-2Kb molecule complexed with three different peptide antigens were grown in several forms by streak seeding…”
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Enhanced Immune Presentation of a Single-chain Major Histocompatibility Complex Class I Molecule Engineered to Optimize Linkage of a C-terminally Extended Peptide by Lybarger, Lonnie, Yu, Y.Y.Lawrence, Miley, Michael J., Fremont, Daved H., Myers, Nancy, Primeau, Tina, Truscott, Steven M., Connolly, Janet M., Hansen, Ted H.

“…Major histocompatibility complex class I molecules can be expressed as single polypeptides wherein the antigenic peptide, β2-microglobulin, and heavy chain are…”
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