Search Results - "Freke, Mark C"

Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions by Caniga, Michael, Cabal, Antonio, Mehta, Khamir, Ross, David S, Gil, Malgorzata A, Woodhouse, Janice D, Eckman, Joseph, Naber, John R, Callahan, Marissa K, Goncalves, Luciano, Hill, Susan E, Mcleod, Robbie L, McIntosh, Fraser, Freke, Mark C, Visser, Sandra A G, Johnson, Neil, Salmon, Michael, Cicmil, Milenko

“…Understanding the relationship between dose, lung exposure, and drug efficacy continues to be a challenging aspect of inhaled drug development. An experimental…”
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Multisite Analysis of Lesions in the Respiratory Tract of the Rat and Nonhuman Primate (Cynomolgus Monkey) Exposed to Air, Vehicle, and Inhaled Small Molecule Compounds by Gregori, Michela, Naylor, Stuart W., Freke, Mark C., Chamanza, Ronnie, Piaia, Alessandro, Hall, A. Peter

“…This paper presents a review of the nature, range, and incidences of background pathology findings in the respiratory tract of cynomolgus monkeys and rats…”
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BSTP Review of 12 Case Studies Discussing the Challenges, Pathology, Immunogenicity, and Mechanisms of Inhaled Biologics by Hall, A. Peter, Tepper, Jeffrey S., Boyle, Molly H., Cary, Maurice G., Flandre, Thierry G., Piaia, Alessandro, Tarnow, Inge, Macri, Nicholas P., Freke, Mark C., Nikula, Kristen J., Paul, Graham R., Cauvin, Annick, Gregori, Michela, Haworth, Richard, Naylor, Stuart, Price, Mark, Robinson, Ian N., Allen, Andrew, Gelzleichter, Tom, Hohlbaum, Andreas M., Manetz, Scott, Wolfreys, Alison, Colman, Karyn, Fleurance, Renaud, Jones, David, Mukaratirwa, Sydney

“…The inhalation route is a relatively novel drug delivery route for biotherapeutics and, as a result, there is a paucity of published data and experience within…”
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