Search Results - "Freitas Lopes, Maria Alice"
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Immune and metabolic shifts during neonatal development reprogram liver identity and function
Published in Journal of hepatology (01-12-2018)“…[Display omitted] •Neonatal livers have very different cellular composition to adults.•Myeloid cells govern liver immune system in newborns.•Several metabolic…”
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Differential Location and Distribution of Hepatic Immune Cells
Published in Cells (Basel, Switzerland) (07-12-2017)“…The liver is one of the main organs in the body, performing several metabolic and immunological functions that are indispensable to the organism. The liver is…”
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Isolation and high‐dimensional phenotyping of gastrointestinal immune cells
Published in Immunology (01-05-2017)“…Summary The gastrointestinal immune system plays a pivotal role in the host relationship with food antigens, the homeostatic microbiome and enteric pathogens…”
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The neonatal liver hosts a spontaneously occurring neutrophil population, exhibiting distinct spatial and functional characteristics from adults
Published in Journal of leukocyte biology (29-03-2024)“…The elusive nature of the liver immune system in newborns remains an important challenge, casting a shadow over our understanding of how to effectively treat…”
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IL-33 signalling in liver immune cells enhances drug-induced liver injury and inflammation
Published in Inflammation research (2018)“…Objective and design The aim of this study was to investigate the contribution of IL-33/ST2 axis in the onset and progression of acute liver injury using a…”
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Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
Published in Gastroenterology (New York, N.Y. 1943) (01-12-2016)“…Background & Aims Resident macrophages are derived from yolk sac precursors and seed the liver during embryogenesis. Native cells may be replaced by bone…”
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Prolonged neutrophil survival at necrotic sites is a fundamental feature for tissue recovery and resolution of hepatic inflammation
Published in Journal of leukocyte biology (01-10-2020)“…Neutrophils were classically described as powerful effectors of acute inflammation, and their main purpose was assumed to be restricted to pathogen killing…”
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Chronic ingestion of Primex-Z, compared with other common fat sources, drives worse liver injury and enhanced susceptibility to bacterial infections
Published in Nutrition (Burbank, Los Angeles County, Calif.) (01-01-2021)“…The aim of this study was to investigate putative different outcomes on the development of non-alcoholic fatty liver disease in mice using fat options…”
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Imaging and immunometabolic phenotyping uncover changes in the hepatic immune response in the early phases of NAFLD
Published in JHEP reports (01-08-2020)“…The precise determination of non-alcoholic fatty liver disease (NAFLD) onset is challenging. Thus, the initial hepatic responses to fat accumulation, which may…”
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Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose
Published in Cells (Basel, Switzerland) (01-08-2018)“…Hepatocytes may rupture after a drug overdose, and their intracellular contents act as damage-associated molecular patterns (DAMPs) that lead to additional…”
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