Search Results - "Freitas Lima, Leandro C"

The mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice by Shannon, Christopher E., Bakewell, Terry, Fourcaudot, Marcel J., Ayala, Iriscilla, Smelter, Annie A., Hinostroza, Edgar A., Romero, Giovanna, Asmis, Mara, Freitas Lima, Leandro C., Wallace, Martina, Norton, Luke

“…The mitochondrial pyruvate carrier (MPC) occupies a critical node in intermediary metabolism, prompting interest in its utility as a therapeutic target for the…”
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Adipokines, diabetes and atherosclerosis: an inflammatory association by Freitas Lima, Leandro C, Braga, Valdir de Andrade, do Socorro de França Silva, Maria, Cruz, Josiane de Campos, Sousa Santos, Sérgio H, de Oliveira Monteiro, Matheus M, Balarini, Camille de Moura

“…Cardiovascular diseases can be considered the most important cause of death in diabetic population and diabetes can in turn increase the risk of cardiovascular…”
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Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain by Alves-Silva, Thaís, Húngaro, Talita G.R., Freitas-Lima, Leandro C., de Melo Arthur, Gabriel, Arruda, Adriano C., Santos, Raisa B., Oyama, Lila M., Mori, Marcelo A.S., Bader, Michael, Araujo, Ronaldo C.

“…Given the importance of the kinin B1 receptor in insulin and leptin hormonal regulation, which in turn is crucial in maternal adaptations to ensure nutrient…”
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Angiotensin-Converting Enzyme Inhibitor Protects Against Cisplatin Nephrotoxicity by Modulating Kinin B1 Receptor Expression and Aminopeptidase P Activity in Mice by Estrela, Gabriel R., Wasinski, Frederick, Gregnani, Marcos F., Freitas-Lima, Leandro C., Arruda, Adriano C., Morais, Rafael Leite, Malheiros, Denise MAC, Camara, Niels O. S., Pesquero, João Bosco, Bader, Michael, Barros, Carlos Castilho, Araújo, Ronaldo Carvalho

“…Cisplatin is a highly effective chemotherapeutic agent. However, its use is limited by nephrotoxicity. Enalapril is an angiotensin I-converting enzyme…”
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Subacute cadmium exposure disrupts the hypothalamic-pituitary-gonadal axis, leading to polycystic ovarian syndrome and premature ovarian failure features in female rats by da Costa, Charles S., Oliveira, Thiago F., Freitas-Lima, Leandro C., Padilha, Alessandra S., Krause, Maiara, Carneiro, Maria Tereza W.D., Salgado, Breno S., Graceli, Jones B.

“…Cadmium (Cd), a toxic heavy metal, is a known endocrine disruptor that is associated with reproductive complications. However, few studies have explored the…”
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High‐refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats by Niño, Oscar M.S., da Costa, Charles S., Torres, Karine M., Zanol, Jordana F., Freitas-Lima, Leandro C., Miranda-Alves, Leandro, Graceli, Jones B.

“…[Display omitted] •High carbohydrate diet is a diet-induced obese model.•High carbohydrate diet induces polycystic ovary syndrome features.•High carbohydrate…”
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The obesogen tributyltin induces abnormal ovarian adipogenesis in adult female rats by de Araújo, Julia F.P., Podratz, Priscila L., Sena, Gabriela C., Merlo, Eduardo, Freitas-Lima, Leandro C., Ayub, Júlia Gringorini Mori, Pereira, Amanda Fidalgo Zogaib, Santos-Silva, Ana Paula, Miranda-Alves, Leandro, Silva, Ian V., Graceli, Jones B.

“…•TBT disrupted the proper functioning of the reproductive tract in adult female rats.•TBT leads to abnormal ovarian adipogenesis by PPARγ, C/EBP-β and Lipin-1…”
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Tributyltin and high‐refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats by Zanol, Jordana F., Niño, Oscar M.S., da Costa, Charles S., Freitas-Lima, Leandro C., Miranda-Alves, Leandro, Graceli, Jones B.

“…[Display omitted] •TBT+HCD exposure impairs TYG index compared with CON, TBT and HCD treatment.•TBT+HCD exposure increases adipocyte hypertrophy compared with…”
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Environmental obesogen tributyltin chloride leads to abnormal hypothalamic-pituitary-gonadal axis function by disruption in kisspeptin/leptin signaling in female rats by Sena, Gabriela C., Freitas-Lima, Leandro C., Merlo, Eduardo, Podratz, Priscila L., de Araújo, Julia F.P., Brandão, Poliane A.A., Carneiro, Maria T.W.D., Zicker, Marina C., Ferreira, Adaliene V.M., Takiya, Christina M., de Lemos Barbosa, Carolina M., Morales, Marcelo M., Santos-Silva, Ana Paula, Miranda-Alves, Leandro, Silva, Ian V., Graceli, Jones B.

“…Tributyltin chloride (TBT) is a xenobiotic used as a biocide in antifouling paints that has been demonstrated to induce endocrine-disrupting effects, such as…”
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Disruption of fertility, placenta, pregnancy outcome, and multigenerational inheritance of hepatic steatosis by organotin exposure from contaminated seafood in rats by Podratz, Priscila L., Merlo, Eduardo, de Araújo, Julia F.P., Ayub, Julia G.M., Pereira, Amanda F.Z., Freitas-Lima, Leandro C., da Costa, Mércia B., Miranda-Alves, Leandro, Cassa, Sonara G.S., Carneiro, Maria Tereza W.D., Fillmann, Gilberto, Graceli, Jones B.

“…Early life exposure to endocrine-disrupting chemicals (EDCs) is an emerging risk factor for development of complications later in life and in subsequent…”
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Subacute high-refined carbohydrate diet leads to abnormal reproductive control of the hypothalamic-pituitary axis in female rats by Zimerman, Jeanini, Niño, Oscar M.S., da Costa, Charles S., Zanol, Jordana F., Comério, Milena, da Gama de Souza, Letícia N., Miranda-Alves, Leandro, Miranda, Rosiane A., Lisboa, Patrícia C., Camilo, Tays A., Rorato, Rodrigo, Alves, Guilherme Andrade, Frazão, Renata, Zomer, Helena D., Freitas-Lima, Leandro C., Graceli, Jones B.

“…We previously reported that female rats placed on a diet containing refined carbohydrates (HCD) resulted in obesity and reproductive abnormalities, such as…”
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URB597 inhibits oxidative stress induced by alcohol binging in the prefrontal cortex of adolescent rats by Pelição, Renan, Santos, Matheus C., Freitas-Lima, Leandro C., Meyrelles, Silvana S., Vasquez, Elisardo C., Nakamura-Palacios, Ester M., Rodrigues, Lívia C.M.

“…•Acute and chronic binge ethanol induces oxidative stress in PFC of adolescent rats.•Previous administration of URB597 inhibits oxidative stress caused by…”
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Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats by Coutinho, João V.S., Freitas-Lima, Leandro C., Freitas, Frederico F.C.T., Freitas, Flávia P.S., Podratz, Priscila L., Magnago, Rafaella P.L., Porto, Marcella L., Meyrelles, Silvana S., Vasquez, Elisardo C., Brandão, Poliane A.A., Carneiro, Maria T.W.D., Paiva-Melo, Francisca D., Miranda-Alves, Leandro, Silva, Ian V., Gava, Agata L., Graceli, Jones B.

“…[Display omitted] •TBT reduced GFR and increased proteinuria levels in female rats.•TBT increased renal mensagial expansion and collagen deposition.•TBT…”
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Pomegranate Extract Enhances Endothelium-Dependent Coronary Relaxation in Isolated Perfused Hearts from Spontaneously Hypertensive Ovariectomized Rats by Delgado, Nathalie T B, Rouver, Wender do N, Freitas-Lima, Leandro C, de Paula, Tiago D-C, Duarte, Andressa, Silva, Josiane F, Lemos, Virgínia S, Santos, Alexandre M C, Mauad, Helder, Santos, Roger L, Moysés, Margareth R

“…Decline in estrogen levels promotes endothelial dysfunction and, consequently, the most prevalent cardiovascular diseases in menopausal women. The use of…”
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