Search Results - "Freitas, Rosana H. C. N"

Comparative chemical and biological hydrolytic stability of homologous esters and isosteres by de Souza, Hygor M. R., Guedes, Jéssica S., Freitas, Rosana H. C. N., Gelves, Luis G. V., Fokoue, Harold H., Sant'Anna, Carlos Mauricio R., Barreiro, Eliezer J., Lima, Lidia M.

“…Esters are one of the major functional groups present in the structures of prodrugs and bioactive compounds. Their presence is often associated with hydrolytic…”
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Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties by Cordeiro, Natália M, Freitas, Rosana H C N, Fraga, Carlos A M, Fernandes, Patricia D

“…LASSBio-1524 was designed as inhibitor of the IKK-β (kappa β kinase inhibitor) enzyme, which participates in the activation of the nuclear factor κB (NF-κB)…”
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Juglone: A Versatile Natural Platform for Obtaining New Bioactive Compounds by Dos S Moreira, Caroline, Santos, Thaís B, Freitas, Rosana H C N, Pacheco, Paulo A F, da Rocha, David R

“…Juglone is a metabolite produced by several species of plants, in particular Juglans nigra. Additionally, juglone is a 1,4-naphthoquinone that has several…”
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New 2-amino-pyridinyl-N-acylhydrazones: Synthesis and identification of their mechanism of anti-inflammatory action by Cordeiro, Natalia de Morais, Freitas, Rosana H.C.N., Fraga, Carlos Alberto Manssour, Fernandes, Patricia Dias

“…•A new n-acylhydrazone was synthetized and presented anti-inflammatory effect.•LASSBio-1828 inhibited p-38 activity, cell migration and cytokine…”
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Synthesis and trypanocidal activity of novel pyridinyl-1,3,4-thiadiazole derivatives by Freitas, Rosana H.C.N., Barbosa, Juliana M.C., Bernardino, Patrícia, Sueth-Santiago, Vitor, Wardell, Solange M.S.V., Wardell, James L., Decoté-Ricardo, Débora, Melo, Tatiana G., da Silva, Edson F., Salomão, Kelly, Fraga, Carlos A.M.

“…[Display omitted] •New N-aminobenzyl or N-arylhydrazone 1,3,4-thiadiazole derivatives were synthesized.•Target compounds were designed as analogues of CYP51…”
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Discovery of naphthyl‐N‐acylhydrazone p38α MAPK inhibitors with in vivo anti‐inflammatory and anti‐TNF‐α activity by Freitas, Rosana H. C. N., Cordeiro, Natália M., Carvalho, Patrícia R., Alves, Marina A., Guedes, Isabella A., Valerio, Tayna S., Dardenne, Laurent E., Lima, Lídia M., Barreiro, Eliezer J., Fernandes, Patrícia D., Fraga, Carlos A. M.

“…Protein kinases constitute attractive therapeutic targets for development of new prototypes to treat different chronic diseases. Several available drugs, like…”
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LASSBio-1829 Hydrochloride: Development of a New Orally Active N-Acylhydrazone IKK2 Inhibitor with Anti-inflammatory Properties by Guedes, Isabella A., Freitas, Rosana H. C. N., Cordeiro, Natália M., Nascimento, Thaís S. do, Valerio, Tayna S., Fernandes, Patrícia D., Dardenne, Laurent E., Fraga, Carlos A. M.

“…Inhibitor of nuclear factor κB kinase 2 (IKK2) is suggested to be a potential target for the development of novel anti‐inflammatory and anticancer drugs. In…”
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Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-[alpha] Effect and Remarkable Anti-Inflammatory Properties by Cordeiro, Natália M, Freitas, Rosana H. C. N, Fraga, Carlos A. M, Fernandes, Patricia D

“…LASSBio-1524 was designed as inhibitor of the IKK-[beta] (kappa [beta] kinase inhibitor) enzyme, which participates in the activation of the nuclear factor…”
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