Search Results - "Freitas, Renato Leonardo de"
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Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: The role of prelimbic neocortex-hippocampal connections
Published in Progress in neuro-psychopharmacology & biological psychiatry (30-08-2024)“…Chronic neuropathic pain (NP) is commonly associated with cognitive and emotional impairments. Cannabidiol (CBD) presents a broad spectrum of action with a…”
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The scientific publication becomes more extensive than the article - BrJP data repository
Published in BrJP (01-07-2024)Get full text
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Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of hypothalamically mediated panic-like behaviour
Published in Behavioural brain research (15-02-2017)“…The chemical stimulation of the dorsomedial division of the ventromedial hypothalamic nucleus (dmVMH) with NMDA at 9nmol elicits panic-like behavioural…”
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Infralimbic medial prefrontal cortex alters electroacupuncture effect in animals with neuropathic chronic pain
Published in Behavioural brain research (29-04-2022)“…Morphological reorganization in the neural networks of the medial prefrontal cortex (mPFC) may be involved in the development of chronic neuropathic pain (NP)…”
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Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: Comparison between the polygonal arena with a burrow and the circular enclosure of an open-field test
Published in Behavioural brain research (01-02-2016)“…•Blockade of GABAA receptors in DMH, PH and dPAG evokes defensive behavioural response.•Bicuculline treatment into the DMH and PH induces oriented…”
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The endogenous opioid system modulates defensive behavior evoked by Crotalus durissus terrificus: Panicolytic-like effect of intracollicular non-selective opioid receptors blockade
Published in Journal of psychopharmacology (Oxford) (01-01-2019)“…Background: There is a controversy regarding the key role played by opioid peptide neurotransmission in the modulation of panic-attack-related responses. Aims:…”
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Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid CB1 receptor
Published in The international journal of neuropsychopharmacology (01-09-2013)“…It has been shown that GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei (DMH and VMH, respectively) induces elaborated defensive…”
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Endogenous opioid peptide-mediated neurotransmission in central and pericentral nuclei of the inferior colliculus recruits μ1 -opioid receptor to modulate post-ictal antinociception
Published in Neuropeptides (Edinburgh) (01-02-2012)“…Abstract Background The aim of the present work was to investigate the involvement of the μ1 -endogenous opioid peptide receptor-mediated system in post-ictal…”
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Nitric oxide-signalling affects panic-like defensive behaviour and defensive antinociception neuromodulation in the prelimbic cerebral cortex
Published in Brain research (01-12-2024)“…Effect of microinjection of either NPLA (NOS inhibitor) or c-PTIO (NO scavenger) in the prelimbic division (PrL) of the medial prefrontal cortex (mPFC),…”
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CB1-cannabinoid-, TRPV1-vanilloid- and NMDA-glutamatergic-receptor-signalling systems interact in the prelimbic cerebral cortex to control neuropathic pain symptoms
Published in Brain research bulletin (01-12-2020)“…[Display omitted] •PrL cortex is connected to dorsal thalamus nuclei related to pain control.•PrL cortex potentiated mechanical allodynia by NMDA and TRPV1…”
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A publicação científica torna-se maior que o artigo - repositório de dados da BrJP
Published in BrJP (2024)Get full text
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Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice
Published in Journal of neuroscience research (01-02-2020)“…The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury‐based model of neuropathic pain (NP). Comorbidities of NP such as depression,…”
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N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain
Published in Neurochemical research (01-09-2019)“…The mechanisms underlying chronic and neuropathic pain pathology involve peripheral and central sensitisation. The medial prefrontal cortex (mPFC) seems to…”
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Effect of electrical and chemical (activation versus inactivation) stimulation of the infralimbic division of the medial prefrontal cortex in rats with chronic neuropathic pain
Published in Experimental brain research (01-12-2023)“…Neuropathic pain (NP) represents a complex disorder with sensory, cognitive, and emotional symptoms. The medial prefrontal cortex (mPFC) takes critical…”
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Cortical Neurostimulation and N-Methyl-D-Aspartate Glutamatergic Receptor Activation in the Dysgranular Layer of the Posterior Insular Cortex Modulate Chronic Neuropathic Pain
Published in Neuromodulation (Malden, Mass.) (01-12-2023)“…The dysgranula parts of the posterior insular cortex (PIC) stimulation (PICS) has been investigated as a new putative cortical target for nonpharmacologic…”
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The primary motor cortex electrical and chemical stimulation attenuates the chronic neuropathic pain by activation of the periaqueductal grey matter: The role of NMDA receptors
Published in Behavioural brain research (11-10-2021)“…Effect of chemical (c) and electrical (e) stimulation in the primary (M1) motor cortex (MCS) on mechanical allodynia in chronic NP induced by adapted CCI of…”
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Mygalin, an Acanthoscurria gomesiana spider-derived synthetic, modulates haloperidol-induced cataleptic state in mice
Published in Neuroscience letters (18-01-2024)“…Haloperidol (HAL) is an antipsychotic used in the treatment of schizophrenia. However, adverse effects are observed in the extrapyramidal tracts due to its…”
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µ1-Opioid receptors in the dorsomedial and ventrolateral columns of the periaqueductal grey matter are critical for the enhancement of post-ictal antinociception
Published in Synapse (New York, N.Y.) (01-12-2016)“…Generalised tonic and tonic–clonic seizures are followed by significant increase in nociceptive thresholds in both laboratory animals and humans. The…”
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An Adapted Chronic Constriction Injury of the Sciatic Nerve Produces Sensory, Affective, and Cognitive Impairments: A Peripheral Mononeuropathy Model for the Study of Comorbid Neuropsychiatric Disorders Associated with Neuropathic Pain in Rats
Published in Pain medicine (Malden, Mass.) (23-02-2021)“…Abstract Background Chronic constriction injury (CCI) is a model of neuropathic pain induced by four loose ligatures around the sciatic nerve. This work aimed…”
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Intraperitoneal cannabidiol attenuates neonatal germinal matrix hemorrhage-induced neuroinflamation and perilesional apoptosis
Published in Neurological research (New York) (02-11-2019)“…Background. As the survival of preterm infants has increased significantly, germinal matrix hemorrhage (GMH) has become an important public health issue…”
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