Search Results - "Freitas, Guilherme B."

Protective actions of exercise‐related FNDC5/Irisin in memory and Alzheimer’s disease by Freitas, Guilherme B., Lourenco, Mychael V., De Felice, Fernanda G.

“…The proportion of elderly populations is rapidly booming, and human lifespan has considerably increased in the past century because of scientific and medical…”
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Irisin stimulates protective signaling pathways in rat hippocampal neurons by Lourenco, Mychael V., de Freitas, Guilherme B., Raony, Ícaro, Ferreira, Sergio T., De Felice, Fernanda G.

“…Physical exercise stimulates neuroprotective pathways, has pro-cognitive actions, and alleviates memory impairment in Alzheimer’s disease (AD). Irisin is an…”
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Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models by Lourenco, Mychael V., Frozza, Rudimar L., de Freitas, Guilherme B., Zhang, Hong, Kincheski, Grasielle C., Ribeiro, Felipe C., Gonçalves, Rafaella A., Clarke, Julia R., Beckman, Danielle, Staniszewski, Agnieszka, Berman, Hanna, Guerra, Lorena A., Forny-Germano, Letícia, Meier, Shelby, Wilcock, Donna M., de Souza, Jorge M., Alves-Leon, Soniza, Prado, Vania F., Prado, Marco A. M., Abisambra, Jose F., Tovar-Moll, Fernanda, Mattos, Paulo, Arancio, Ottavio, Ferreira, Sergio T., De Felice, Fernanda G.

“…Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an…”
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Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice by Ribeiro, Felipe C., Cozachenco, Danielle, Heimfarth, Luana, Fortuna, Juliana T. S., de Freitas, Guilherme B., de Sousa, Jorge M., Alves-Leon, Soniza V., Leite, Renata E. P., Suemoto, Claudia K., Grinberg, Lea T., De Felice, Fernanda G., Lourenco, Mychael V., Ferreira, Sergio T.

“…The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded…”
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Oxidative stress fuels Trypanosoma cruzi infection in mice by Paiva, Claudia N, Feijó, Daniel F, Dutra, Fabianno F, Carneiro, Vitor C, Freitas, Guilherme B, Alves, Letícia S, Mesquita, Jacilene, Fortes, Guilherme B, Figueiredo, Rodrigo T, Souza, Heitor S P, Fantappié, Marcelo R, Lannes-Vieira, Joseli, Bozza, Marcelo T

“…Oxidative damage contributes to microbe elimination during macrophage respiratory burst. Nuclear factor, erythroid-derived 2, like 2 (NRF2) orchestrates…”
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Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors by De Freitas, Guilherme B.L., da Silva, Leandro L., Romeiro, Nelilma C., Fraga, Carlos A.M.

“…This paper describes CoMFA and CoMSIA studies for affinity and selectivity of a series of indole ligands to cannabinoid CB1 and CB2 receptors. The developed…”
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Formulation, characterization, and in vitro/in vivo studies of capsaicin-loaded albumin nanoparticles by De Freitas, Guilherme B.L., De Almeida, Durinézio J., Carraro, Emerson, Kerppers, Ivo I., Martins, Guilherme A.G., Mainardes, Rubiana M., Khalil, Najeh M., Messias-Reason, Iara J.T.

“…Capsaicin (CAP) is a secondary metabolite with high therapeutic potential. It displays several bioactive properties including hypolipidemic, antioxidant,…”
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CoMFA/CoMSIA 3D-QSAR of pyrimidine inhibitors of Pneumocystis carinii dihydrofolate reductase by Santos-Filho, Osvaldo A., Forge, Delphine, Hoelz, Lucas V. B., de Freitas, Guilherme B. L., Marinho, Thiago O., Araújo, Jocley Q., Albuquerque, Magaly G., de Alencastro, Ricardo B., Boechat, Nubia

“…Pneumocystis carinii is typically a non-pathogenic fungus found in the respiratory tract of healthy humans. However, it may cause P. carinii pneumonia (PCP) in…”
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FNDC5/irisin expression stimulates neuroprotective pathways in hippocampal neurons and associates with Alzheimer’s disease pathology by Raony, Ícaro, de Freitas, Guilherme B., Ferreira, Sergio T., Lourenco, Mychael V., De Felice, Fernanda G.

“…Background Irisin is an exercise‐linked myokine produced by cleavage of the membrane precursor fibronectin type III domain‐containing protein 5 (FNDC5) in…”
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Synaptic proteasome is inhibited in Alzheimer’s disease models and is associated with memory impairment in mice by Ribeiro, Felipe C., Ferreira, Danielle Cozachenco, Fortuna, Juliana, de Freitas, Guilherme B., Souza, Jorge M, Alves‐Leon, Soniza, Leite, Renata Elaine Paraizo, Suemoto, Claudia Kimie, Grinberg, Lea T., De Felice, Fernanda G., Lourenco, Mychael V., Ferreira, Sergio T.

“…Background The proteasome plays key roles in neuronal function by regulating protein turnover, quality control, and elimination of oxidized and misfolded…”
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Difficulties in antifungal therapy with amphotericin B and the continuous search for new formulations: A literature review by Ketllyn, S Voncik, B aacute rbara, L Fermino, Nath aacute lia, C S Cardoso, Raissa, H de Mattos, Eliz, C P Pinto, Jheneffer, D Ignachewski, Emerson, Carraro, Guilherme, B L de Freitas, Weber, C F N da Silva, Juliana, S Bonini

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Evaluation of curcumin toxicity in rats through biochemical and hematological parameters by Ketllyn, S Voncik, Raissa, H de Mattos, Weber, C F N da Silva, Guilherme, B L de Freitas, Timothy, G Cavazzatto, Joao, B T da Rocha, Najeh, M Khalil, Juliana, S Bonini

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