Search Results - "Freitas, Fatima R"

Use of paclitaxel carried in lipid core nanoparticles in patients with late-stage solid cancers with bone metastases: Lack of toxicity and therapeutic benefits by Vital, Carolina G., Maranhão, Raul C., Freitas, Fatima R., Van Eyll, Brigitte M., Graziani, Silvia R.

“…•LDE-PTX at 175 mg/m2/3wk dose was devoid of toxicity at > 3rd line treatment.•Among 18 LDE-PTX treated patients, 9 had PFS > 6 months and 2 had…”
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Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure by Martinelli, Ana Elisa M, Maranhão, Raul C, Carvalho, Priscila O, Freitas, Fatima R, Silva, Bruna M O, Curiati, Milena N C, Kalil Filho, Roberto, Pereira-Barretto, Antonio Carlos

“…Heart failure (HF) courses with chronic inflammatory process and alterations in lipid metabolism may aggravate the disease. The aim was to test whether the…”
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Thyroid hormone receptor β-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats by Villicev, Cássio M, Freitas, Fatima R S, Aoki, Marcelo S, Taffarel, Cássio, Scanlan, Thomas S, Moriscot, Anselmo S, Ribeiro, Miriam O, Bianco, Antonio C, Gouveia, Cecília H A

“…It is well known that thyroid hormone affects body composition; however, the effect of the thyroid hormone receptor β (TRβ)-selective thyromimetic GC-1 on this…”
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Androgen deprivation therapy improves the in vitro capacity of high-density lipoprotein (HDL) to receive cholesterol and other lipids in patients with prostate carcinoma by Albuquerque, Cicero P, Freitas, Fatima R, Martinelli, Ana Elisa M, Lima, Josefa H, Coelho, Rafael F, Serrano, Jr, Carlos V, Nahas, Willian C, Kalil Filho, Roberto, Maranhão, Raul C

“…Androgen deprivation therapy (ADT) is widely used in the treatment of testosterone-dependent prostate carcinomas. ADT often increases plasma LDL and HDL…”
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Double disruption of α2A‐ and α2C ‐adrenoceptors results in sympathetic hyperactivity and high‐bone‐mass phenotype by Fonseca, Tatiana L, Jorgetti, Vanda, Costa, Cristiane C, Capelo, Luciane P, Covarrubias, Ambart E, Moulatlet, Ana C, Teixeira, Marilia B, Hesse, Eric, Morethson, Priscilla, Beber, Eduardo H, Freitas, Fatima R, Wang, Charles C, Nonaka, Keico O, Oliveira, Ricardo, Casarini, Dulce E, Zorn, Telma M, Brum, Patricia C, Gouveia, Cecilia H

“…Evidence demonstrates that sympathetic nervous system (SNS) activation causes osteopenia via β2‐adrenoceptor (β2‐AR) signaling. Here we show that female mice…”
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Breakdown of the blood-ocular barrier as a strategy for the systemic use of nanosystems by Occhiutto, Marcelo L, Freitas, Fatima R, Maranhao, Raul C, Costa, Vital P

“…Several drug delivery systems have been proposed to overcome physiological barriers, improving ocular bioavailability. Systemic routes are seldom used due to…”
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Abnormal Thyroid Hormone Status Differentially Affects Bone Mass Accrual and Bone Strength in C3H/HeJ Mice: A Mouse Model of Type I Deiodinase Deficiency by Zaitune, Clarissa R, Fonseca, Tatiana L, Capelo, Luciane P, Freitas, Fatima R, Beber, Eduardo H, Dora, José M, Wang, Charles C, Miranda-Rodrigues, Manuela, Nonaka, Keico O, Maia, Ana L, Gouveia, Cecilia H A

“…C3H/HeJ (C3H) mice are deficient of type I deiodinase (D1), an enzyme that activates thyroid hormone (TH), converting thyroxine (T4) to triiodothyronine (T3)…”
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An artificial nanoemulsion carrying paclitaxel decreases the transplant heart vascular disease: A study in a rabbit graft model by Lourenço-Filho, Domingos D., MD, PhD, Maranhão, Raul C., MD, PhD, Méndez-Contreras, Carlos A., MD, Tavares, Elaine R., BSci, Freitas, Fatima R., PhD, Stolf, Noedir A., MD, PhD

“…Objective In previous studies cholesterol-rich nanoemulsions (LDE) resembling low-density lipoprotein were shown to concentrate in atherosclerotic lesions of…”
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Intraoperative paclitaxel associated with lipid nanoparticles in trabeculectomy by Occhiutto, Marcelo L., Passos, Thais H. M., Freitas, Fatima R., Maranhão, Raul C., Costa, Vital P.

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Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly by Maranhão, Raul C., Pala, Daniela, Freitas, Fatima R.

“…The speed of removal from the plasma of apolipoprotein B-containing lipoproteins, for example, chylomicrons, VLDL and LDL is determinant of the plasma…”
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Hydroxychloroquine increased cholesterol transfer to high-density lipoprotein in systemic lupus erythematosus: A possible mechanism for the reversal of atherosclerosis in the disease by Lang, Maria G, Vinagre, Carmen GC, Bonfa, Eloisa, Freitas, Fatima R, Pasoto, Sandra G, Brito, Tatiane S, Seguro, Luciana PC, Maranhão, Raul C, Borba, Eduardo F

“…Introduction The beneficial effect of hydroxychloroquine (HCQ) in decreasing LDL levels on Systemic Lupus Erythematosus (SLE) is well defined. The influence of…”
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HDL metabolism and atheroprotection: predictive value of lipid transfers by Maranhão, Raul C, Freitas, Fatima R

“…High-density lipoprotein (HDL) intravascular metabolism is complex, and the major HDL functions are esterification of cholesterol and reverse cholesterol…”
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The Thyroid Hormone Receptor β‐Specific Agonist GC‐1 Selectively Affects the Bone Development of Hypothyroid Rats by Freitas, Fatima RS, Capelo, Luciane P, O'Shea, Patrick J, Jorgetti, Vanda, Moriscot, Anselmo S, Scanlan, Thomas S, Williams, Graham R, Zorn, Telma MT, Gouveia, Cecilia HA

“…We investigated the effects of GC‐1, a TRβ‐selective thyromimetic, on bone development of hypothyroid rats. Whereas T3 reverted the IGF‐I deficiency and the…”
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Paclitaxel Associated With Lipid Nanoparticles as a New Antiscarring Agent in Experimental Glaucoma Surgery by Occhiutto, Marcelo L, Freitas, Fatima R, Lima, Patrícia P, Maranhão, Raul C, Costa, Vital P

“…To investigate the effects of paclitaxel associated with lipid nanoemulsions (LDE-PTX) on postoperative scarring in rabbits undergoing trabeculectomy…”
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Regular Practice of Physical Activity Improves Cholesterol Transfers to High-Density Lipoprotein (HDL) and Other HDL Metabolic Parameters in Older Adults by Braga, Pedro G S, Freitas, Fatima R, Bachi, André L L, Amirato, Gislene R, Baroni, Roberta V, Alves, Maria Janieire N N, Vieira, Rodolfo P, Vaisberg, Mauro W, Aldin, Marlene N, Kalil Filho, Roberto, Figueiredo Neto, Antônio M, Damasceno, Nágila R T, Tavoni, Thauany M, Maranhão, Raul C

“…The effects of regular physical activity on two important anti-atherosclerosis functions of high-density lipoprotein (HDL), namely its capacity to receive both…”
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LIPID TRANSFER TO HDL IN PATIENTS WITH HEART FAILURE WAS DIMINISHED AND IS CORRELATED WITH SEVERITY OF THE DISEASE by Martinelli, Ana Elisa Marabini, Maranhao, Raul C, Carvalho, Priscila O, Curiati, Milena N.C, Tavoni, Thauany M, Freitas, Fatima R, Barretto, Antonio

“…The study findings highlight the extensive involvement of the plasma lipids and HDL metabolism with HF presence and severity and the importance of elucidating…”
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Lipid transfer to high‐density lipoproteins in coronary artery disease patients with and without previous cerebrovascular ischemic events by Barbosa, Carlos J.D.G., Maranhão, Raul C., Barreiros, Renata S., Freitas, Fatima R., Franci, André, Strunz, Célia M.C., Arantes, Flávia B.B., Tavoni, Thauany M., Ramires, José A.F., Kalil Filho, Roberto, Nicolau, José C.

“…Background Patients with coronary artery disease (CAD) and previous ischemic cerebrovascular events (ICVE, ischemic stroke, or transitory ischemic attack)…”
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Lipids transfer to HDL in patients with heart failure was diminished and is correlated with IL-6 and BNP levels by Marabini Martine, Ana Elisa, Carvalho, Priscila O., Curiatti, Milena N.C., Miranda, Bruna o., Freitas, Fatima R., Kalil Filho, Roberto, Pereira Barretto, Antonio Carlos, Maranhão, Raul C.

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Reduction of Atherosclerotic Lesions by the Chemotherapeutic Agent Carmustine Associated to Lipid Nanoparticles by Daminelli, Elaine N., Martinelli, Ana E. M., Bulgarelli, Adriana, Freitas, Fatima R., Maranhão, Raul C.

“…Purpose After injection in the bloodstream, a lipid nanoparticle (LDE) resembling low-density lipoprotein (LDL) concentrates in atherosclerotic lesions of…”
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Aerobic Training in Young Men Increases the Transfer of Cholesterol to High Density Lipoprotein In Vitro: Impact of High Density Lipoprotein Size by da Silva, Jeferson L., Maranhão, Raul C., Silva, Michelle S.M., Dias, Rodrigo G., Freitas, Fatima R., Bolani, Wladimir, Lemos Junior, José R., Alves, Cleber R., Oliveira, Patrícia A., Alves, Guilherme B., Oliveira, Edilamar M., Negrao, Carlos Eduardo, Krieger, José Eduardo, Pereira, Alexandre C., Silva, Gisele A., Souza, José P., Vinagre, Carmen G.C.

“…Exercise training not only improves the plasma lipid profile but also reduces risk of developing coronary heart disease. We investigate whether plasma lipids…”
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