Search Results - "Freire, Joao Miguel"

Receptors and routes of dengue virus entry into the host cells by Cruz-Oliveira, Christine, Freire, João Miguel, Conceição, Thaís M., Higa, Luiza M., Castanho, Miguel A.R.B., Da Poian, Andrea T.

“…Dengue is the most prevalent arthropod-borne viral disease, caused by dengue virus, a member of the Flaviviridae family. Its worldwide incidence is now a major…”
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Cell‐penetrating peptides: A tool for effective delivery in gene‐targeted therapies by Figueiredo, Inês Rego, Freire, João Miguel, Flores, Luís, Veiga, Ana Salomé, Castanho, Miguel A.R.B.

“…The current landscapes of novel therapeutic approaches rely mostly on gene‐targeted technologies, enabling to fight rare genomic diseases, from infections to…”
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Mining viral proteins for antimicrobial and cell-penetrating drug delivery peptides by Freire, João Miguel, Almeida Dias, Susana, Flores, Luís, Veiga, Ana Salomé, Castanho, Miguel A R B

“…The need for more effective and safer pharmaceuticals is a persistent quest. Microbial adaptations create the need to permanently develop new antimicrobials…”
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Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein by Freire, João Miguel, Veiga, Ana Salomé, Conceição, Thaís M, Kowalczyk, Wioleta, Mohana-Borges, Ronaldo, Andreu, David, Santos, Nuno C, Da Poian, Andrea T, Castanho, Miguel A R B

“…Supercharged proteins are a recently identified class of proteins that have the ability to efficiently deliver functional macromolecules into mammalian cells…”
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Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom by Pérez-Peinado, Clara, Dias, Susana Almeida, Domingues, Marco M., Benfield, Aurélie H., Freire, João Miguel, Rádis-Baptista, Gandhi, Gaspar, Diana, Castanho, Miguel A.R.B., Craik, David J., Henriques, Sónia Troeira, Veiga, Ana Salomé, Andreu, David

“…Crotalicidin (Ctn), a cathelicidin-related peptide from the venom of a South American rattlesnake, possesses potent antimicrobial, antitumor, and antifungal…”
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Monitoring antibacterial permeabilization in real time using time-resolved flow cytometry by Freire, João Miguel, Gaspar, Diana, de la Torre, Beatriz Garcia, Veiga, Ana Salomé, Andreu, David, Castanho, Miguel A.R.B.

“…Despite the intensive study of antibiotic-induced bacterial permeabilization, its kinetics and molecular mechanism remain largely elusive. A new methodology…”
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siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model by Freire, João Miguel, Rego de Figueiredo, Inês, Valle, Javier, Veiga, Ana Salomé, Andreu, David, Enguita, Francisco J., Castanho, Miguel A.R.B.

“…Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by a single gene mutation, a reciprocal translocation that originates the Bcr-Abl gene…”
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Peptides as models for the structure and function of viral capsid proteins: Insights on dengue virus capsid by Freire, João Miguel, Veiga, Ana Salomé, de la Torre, Beatriz G., Santos, Nuno C., Andreu, David, Da Poian, Andrea T., Castanho, Miguel A. R. B.

“…ABSTRACT The structural organization of viral particles is among the most astonishing examples of molecular self‐assembly in nature, involving proteins,…”
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siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model by Freire, João Miguel, Rego de Figueiredo, Inês, Valle, Javier, Veiga, Ana Salomé, Andreu, David, Enguita, Francisco J., Castanho, Miguel A.R.B.

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Quantifying molecular partition of cell-penetrating peptide-cargo supramolecular complexes into lipid membranes: optimizing peptide-based drug delivery systems by Freire, João Miguel, Veiga, Ana Salomé, de la Torre, Beatriz G., Andreu, David, Castanho, Miguel A. R. B.

“…One of the major challenges in the drug development process is biodistribution across epithelia and intracellular drug targeting. Cellular membrane…”
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New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins by Dias, Susana A, Freire, João M, Pérez-Peinado, Clara, Domingues, Marco M, Gaspar, Diana, Vale, Nuno, Gomes, Paula, Andreu, David, Henriques, Sónia T, Castanho, Miguel A R B, Veiga, Ana S

“…The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial…”
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Intracellular Nucleic Acid Delivery by the Supercharged Dengue Virus Capsid Protein: e81450 by Freire, Joao Miguel, Veiga, Ana Salome, Conceicao, Thais M, Kowalczyk, Wioleta, Mohana-Borges, Ronaldo, Andreu, David, Santos, Nuno C, Poian, Andrea TDa, Castanho, A RB

“…Supercharged proteins are a recently identified class of proteins that have the ability to efficiently deliver functional macromolecules into mammalian cells…”
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Anti-HIV-1 activity of pepRF1, a proteolysis-resistant CXCR4 antagonist derived from Dengue virus capsid protein by cadima couto, carla iris, Tauzin, Alexandra, Miguel Freire, João, Figueira, Tiago, Silva, Rúben D. M., Pérez-Peinado, Clara, Cunha-Santos, Catarina, Bártolo, Inês, Taveira, Nuno, Barrela Patricio Gano, Maria Lurdes, Correia, João, Goncalves, Joao, Mammano, Fabrizio, Andreu, David, Castanho, Miguel, Veiga, Ana Salome

“…Copyright © 2020 American Chemical Society There is an urgent need for the development of new anti-HIV drugs that can complement existing medicines to be used…”
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In vitro characterization of 3D printed scaffolds aimed at bone tissue regeneration by Boga, João C., Miguel, Sónia P., de Melo-Diogo, Duarte, Mendonça, António G., Louro, Ricardo O., Correia, Ilídio J.

“…[Display omitted] •Cylindrical scaffolds were designed with CAD and produced using RP.•3D scaffolds were produced with a TCP/AA mixture and functionalized with…”
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Camargo Guarnieri, Brazilian Composer: A Study of His Creative Life and Works (review) by Freire, João Miguel

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Structural proteins of enveloped virus : From biochemistry to molecular medicine : a focus on Dengue virus by Freire, João Miguel Calado da Silva

“…Dengue virus (DENV) is an underestimated threat to Europe. Every year it infects arround 390 million people worldwide with 20 000 deaths. Due to climate…”
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Camargo Guarnieri, Brazilian Composer: A Study of His Creative Life and Works by Freire, João Miguel

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Novas Abordagens Terapêuticas Para a Regeneração Óssea by Boga, João Miguel Carvalho Freire

“…O envelhecimento da população mundial tem associado um aumento do número de doenças e fraturas ósseas, as quais comprometem a integridade do osso e afetam a…”
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