Search Results - "Freimer, Jake"

GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency by Chen, Amy F., Liu, Arthur J., Krishnakumar, Raga, Freimer, Jacob W., DeVeale, Brian, Blelloch, Robert

“…The enhancer landscape of pluripotent stem cells undergoes extensive reorganization during early mammalian development. The functions and mechanisms behind…”
Get full text

Abstract 7034: Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulation by Joshi, Sahil, Wozniak, Glenn, Gagnon, John, Vucci, Kristina, Merrell, Allyson, Simon, Mandi, Oh, Catherine, Cardozo, Andrew, DeTomaso, David, Chow, Julie, Zheng, Grace, Boroughs, Angela, Joho, Keith, Thakore, Pratiksha, Oh, Soyoung, Freimer, Jake, Cass, Ashley, Sail, Vibhavari, Tocchini, Carla, Sandoval, Marian, Liu, Andrea, Cui, Eric, Drever, Matt, Galvin, Brendan, Milush, Jeff, Gray-Rupp, Levi, Wheeler, Emily, Chen, Bob, Levine, Jacob, Eidenschenk, Celine, Schartner, Jill, Geiger-Schuller, Katie, Huetter, Jan-Christian, Rutz, Sascha, Rozenblatt-Rosen, Orit, Mellman, Ira, Haining, W. Nicholas

“…Abstract T cell exhaustion resulting from chronic antigen stimulation and an immunosuppressive tumor microenvironment limits the efficacy of T cell therapies…”
Get full text

Abstract 7042: Enhancing TCR T cell function in solid tumors through in vivo combinatorial screens and single-cell analysis by Polyak, Dina, Fuhriman, Jessica, Susanto, Josephine, Merrell, Allyson, Simon, Mandi, Oh, Catherine, Cordazo, Andrew, DeTomasso, David, Tocchini, Carla, Sail, Vibhavari, Cui, Eric, Milush, Jeff, Gray-Rupp, Levi, Galvin, Brendan, Murriel, Christopher, Zheng, Grace, Boroughs, Angela C., Thakore, Pratiksha, Oh, Soyoung, Freimer, Jake, Chen, Bob, Eidenschenk, Celine, Wheeler, Emily, Levine, Jacob, Huetter, Jan-Christian, Schartner, Jill, Geiger-Schuller, Katie, Rozenblatt-Rosen, Orit, Rutz, Sascha, Mellman, Ira, Haining, W. Nicholas

“…Abstract The therapeutic potential of T cell therapies for treating solid tumors can be limited by intrinsic T cell exhaustion mechanisms and the suppressive…”
Get full text