Search Results - "Freiburg, Alexandra"
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Series of Exon-Skipping Events in the Elastic Spring Region of Titin as the Structural Basis for Myofibrillar Elastic Diversity
Published in Circulation research (09-06-2000)“…Titins are megadalton-sized filamentous polypeptides of vertebrate striated muscle. The I-band region of titin underlies the myofibrillar passive tension…”
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Molecular Dissection of N2B Cardiac Titin’s Extensibility
Published in Biophysical journal (01-12-1999)“…Titin is a giant filamentous polypeptide of multidomain construction spanning between the Z- and M-lines of the cardiac muscle sarcomere. Extension of the…”
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Striational autoantibodies in myasthenia gravis patients recognize I-band titin epitopes
Published in Journal of neuroimmunology (1998)“…Myasthenia gravis (MG) patients develop autoantibodies primarily against the acetylcholine receptor in the motor endplate, but also against intracellular…”
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Phosphorylation switches specific for the cardiac isoform of myosin binding protein‐C: a modulator of cardiac contraction?
Published in The EMBO journal (01-05-1995)“…Cardiac myosin binding protein‐C (cardiac MyBP‐C, cardiac C protein) belongs to a family of proteins implicated in both regulatory and structural functions of…”
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A molecular map of the interactions between titin and myosin-binding protein C. Implications for sarcomeric assembly in familial hypertrophic cardiomyopathy
Published in European journal of biochemistry (1996)“…The thick filaments of vertebrate striated muscles contain with myosin a number of accessory proteins of the intracellular immunoglobulin superfamily, which…”
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From connecting filaments to co-expression of titin isoforms
Published in Advances in experimental medicine and biology (2000)“…The molecular basis of elasticity in insect flight muscle has been analyzed using both the mechanism of extensibility of titin filaments (Trombitás et al., J…”
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A Molecular Map of the Interactions between Titin and Myosin‐Binding Protein C
Published in European journal of biochemistry (01-01-1996)“…The thick filaments of vertebrate striated muscles contain with myosin a number of accessory proteins of the intracellular immunoglobulin superfamily, which…”
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Molecular tools for the study of titin's differential expression
Published in Advances in experimental medicine and biology (2000)“…Although vertebrate genomes appear to contain only one titin gene, a large variety of quite distinct titin isoforms are expressed in striated muscle tissues…”
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Titin Transcripts in Thymomas
Published in Annals of the New York Academy of Sciences (01-05-1998)Get full text
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Titin Transcripts in Thymomas
Published in Journal of autoimmunity (01-12-1997)“…More than 90% of myasthenia gravis (MG) patients with a thymoma have antibodies against titin. We have identified titin mRNA transcripts in thymomas by RT-PCR…”
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