Search Results - "Freese, A."

Immune responses to AAV in a phase I study for Canavan disease by McPhee, S. W. J., Janson, C. G., Li, C., Samulski, R. J., Camp, A. S., Francis, J., Shera, D., Lioutermann, L., Feely, M., Freese, A., Leone, P.

“…Background Canavan disease is a rare leukodystrophy with no current treatment. rAAV‐ASPA has been developed for gene delivery to the central nervous system…”
Get full text

Strong interaction physics at the luminosity frontier with 22 GeV electrons at Jefferson Lab by Adhikari, D., Afanasev, A., Armstrong, D. S., Avakian, H., Bacchetta, A., Balantekin, A. B., Benmokhtar, F., Bertone, V., Binosi, D., Brash, E. J., Brindza, P. D., Brodsky, S. J., Cardman, L. S., Chen, J.-P., Christopher, A., Christy, E., Cisbani, E., Constantinou, M., Costantini, G., Dusa, S. Covrig, Day, D., De Fazio, F., De Vita, R., de Téramond, G. F., Diefenthaler, M., Djalali, C., Elouadrhiri, L., Evans, G., Fanelli, C., Fernández-Ramírez, C., Gan, L., Gao, F., Gasparian, A., Giacosa, F., Guo, F.-K., Hague, T. J., Hayward, T., Illari, I., Italiano, A., Jarvis, N. S., Jenkins, D. J., Ji, C.-R., Jones, M., Jones, R. T., Keppel, C., Khachatryan, V., Kohl, M., Kuhn, S. E., Liao, J., Mack, D. J., Mamo, K. A., Mariani, C., Markowitz, P., Marukyan, H., Mathieu, V., Maxwell, J., McCaughan, M., Mezrag, C., Miller, G. A., Mineeva, T., Chàvez, J. M. Morgado, Nguyen, D., Niccolai, S., Niculescu, G., Ortega, P. G., Pandey, P., Pasquini, B., Passemar, E., Patel, T., Paul, S. J., Peng, J.-C., Perry, R. J., Piasetzky, E., Pilloni, A., Polosa, A. D., Pospelov, M., Qin, S.-X., Reimer, P. E., Richard, J.-M., Ritman, J., Rivero-Acosta, A., Rogers, T. C., Santiesteban, S. N., Sato, N., Schnell, G., Shepherd, M. R., Shrestha, S., Sparveris, N., Strakovsky, I. I., Strikman, M., Suresh, M., Szczepaniak, A. P., Sznajder, P., Tong, X.-B., Vallarino, S., Wagner, J., Williams, R., Ye, Z., Zhao, Z. W., Zheng, X.

“…Here, the purpose of this document is to outline the developing scientific case for pursuing an energy upgrade to 22 GeV of the Continuous Electron Beam…”
Get full text

Reframing one's teaching: Discovering our teacher selves through reflection and inquiry by Freese, Anne R.

“…Learning to teach is a highly complex and multidimensional process. This self-study, conducted collaboratively by a preservice teacher and a teacher educator,…”
Get full text

Habitat use of the endangered butterfly Euphydryas maturna and forestry in Central Europe by Freese, A, Benes, J, Bolz, R, Cizek, O, Dolek, M, Geyer, A, Gros, P, Konvicka, M, Liegl, A, Stettmer, C

“…The knowledge of ecological requirements of declining butterflies of European woodlands remains limited, which hinders conservation management of their…”
Get full text

Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI by Janson, C G, McPhee, S W J, Francis, J, Shera, D, Assadi, M, Freese, A, Hurh, P, Haselgrove, J, Wang, D J, Bilaniuk, L, Leone, P

“…Canavan disease is a childhood leukodystrophy caused by mutations in the gene for human aspartoacylase ( ASPA), which leads to an abnormal accumulation of the…”
Get more information

Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease by Leone, P., Janson, C. G., Bilianuk, L., Wang, Z., Sorgi, F., Huang, L., Matalon, R., Kaul, R., Zeng, Z., Freese, A., McPhee, S. W., Mee, E., During, M. J.

“…With the ultimate goal of developing safe and effective in vivo gene therapy for the treatment of Canavan disease and other neurological disorders, we…”
Get full text

Implementation of Pressure Injury Prevention Strategies in Acute Care: Results From the 2018-2019 International Pressure Injury Prevalence Survey by Edsberg, Laura E., Cox, Jill, Koloms, Kimberly, VanGilder-Freese, Catherine A.

“…The purpose of this study was to evaluate the implementation of pressure injury (PI) prevention strategies in adult acute care settings in the United States…”
Get full text

Suicide in prisons: describing trends and staff knowledge and preparedness to address suicide by Freese, Rebekah A., Canada, Kelli E., Nichols, Pagena M., McNamara, Brianna

“…Purpose Suicide prevention and intervention in prisons is a challenge. Prisons were not designed to be clinical facilities, yet with the growing numbers of…”
Get full text

Evaluating Learning Outcomes and Assessing Social Work Skill Development: Comparing Online vs. In-Person Education by Canada, Kelli E., Freese, Rebekah A., Bailey, Rachel M., Fitch, Dale

“…This article presents results from an evaluation of learning outcomes in a social work skills class between online and in-person students. Students were…”
Get full text

Oral feeding of an immunodominant MHC donor-derived synthetic class I peptide prolongs graft survival of heterotopic cardiac allografts in a high-responder rat strain combination by Zavazava, Nicholas, Fändrich, Fred, Zhu, Xiaofeng, Freese, Anja, Behrens, Dirk, Yoo‐Ott, Kyoung‐Ae

“…The efficacy of two synthetic major histocompatibility complex (MHC)‐derived DA (RT1.Aa) 25‐mer peptides (residues 56–80 and 96–120) to modulate alloreactivity…”
Get full text

Restorative gene therapy approaches to Parkinson's disease by Freese, A

“…Perhaps one of the most exciting developments in brain research of the past decade is the advent of genetic intervention in human neurologic disease. Although…”
Get more information

Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease by McPhee, S.W.J., Francis, J., Janson, C.G., Serikawa, T., Hyland, K., Ong, E.O., Raghavan, S.S., Freese, A., Leone, P.

“…The tremor rat is a spontaneous epilepsy model with a seizure phenotype caused by a deletion in the aspartoacylase ( ASPA) gene. The absence of ASPA expression…”
Get full text

Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors by Swartz, KJ, During, MJ, Freese, A, Beal, MF

“…Excitatory amino acid (EAA)-mediated synaptic transmission is the most prevalent excitatory system within the mammalian brain. Activation of EAA receptors has…”
Get full text

Tetramethylpiperidine-substituted phenazines as novel anti-plasmodial agents by Makgatho, Marema E., Anderson, Ronald, O'Sullivan, John F., Egan, Timothy J., Freese, Janet A., Cornelius, Nicolene, van Rensburg, Constance E.J.

“…Two novel derivatives of clofazimine [3‐(p‐chloroanilino)‐10‐(p‐chlorophenyl)‐2,10‐dihydro‐2‐isopropylimino)phenazine] and the tetramethylpiperidine…”
Get full text

Precision studies of QCD in the low energy domain of the EIC by Elouadrhiri, L., Afanasev, A., Contalbrigo, M., Cosyn, W., Deshpande, A., Liuti, S., Oh, Y., Richards, D., Vossen, A., Abdolmaleki, H., Albataineh, A., Aidala, C.A., Alexandrou, C., Avagyan, H., Baker, M., Bernauer, J.C., Bissolotti, C., Briscoe, W., Cao, Xu, Carlson, C.E., Cichy, K., Cloet, I.C., Cocuzza, C., Cole, P.L., Constantinou, M., Dilks, C., Djalali, C., Dusa, S.C., El-Bennich, B., El Fassi, L., Frederico, T., Freese, A., Gamberg, L., Ghoshal, R.R., Girod, F.X., Goncalves, V.P., Gotra, Y., Guo, F.K., Guo, X., Hatta, Y., Hayward, T., Isupov, E.L., Jacak, B., Jacobs, W., Jentsch, A., Ji, C.R., Joosten, S., Kang, Z., Kim, A., Klein, S., Kriesten, B., Kumar, A., Kumericki, K., Kuchera, M., Li, Jin, Li, X., Lin, H.-W., Liu, K.F., Liu, Xiaohui, Mathieu, V., McEneaney, M., Mekki, A., Mkrtchyan, H., Mochalov, V., Morozov, V., Nadel-Turonski, P., Okorokov, V.A., Onyie, E., Pappalardo, L.L., Papandreou, Z., Polys, N., Prokudin, A., Przybycien, M., Qiu, J.-W., Ringer, F., Roy, B.J., Schäfer, A., Schmookler, B., Schweitzer, P., Seidl, R., Semenov-Tian-Shansky, K.M., Serna, F., Signori, A., Strakovsky, I., Sufian, R.S., Teodorescu, L., Terry, J., Tessarotto, F., Timmer, C., Cazares, L. Valenzuela, Vladimirov, A., Voutier, E., Watts, D., Wilson, D., Winney, D., Ye, Z., Ye, Zh, Yuan, F., Zachariou, N., Zahed, I.

“…This White Paper aims at highlighting the important benefits in the science reach of the EIC. High luminosity operation is generally desirable, as it enables…”
Get full text

Efficacy of Liposomal Bupivacaine Infiltration on the Management of Total Knee Arthroplasty by Sakamoto, Bryan, Keiser, Shelly, Meldrum, Russell, Harker, Gene, Freese, Andrew

“…Liposomal bupivacaine is a novel extended-duration anesthetic that has recently been used for local infiltration in total knee arthroplasty (TKA). Athough…”
Get more information

Infection of Cultured Central Nervous System Neurons with a Defective Herpes Simplex Virus 1 Vector Results in Stable Expression of Escherichia coli β-Galactosidase by Geller, Alfred I., Freese, Andrew

“…We have developed a defective herpes simplex virus (HSV) vector system that permits the introduction of virtually any gene into mammalian central nervous…”
Get full text

Long-term follow-up after gene therapy for canavan disease by Leone, Paola, Shera, David, McPhee, Scott W J, Francis, Jeremy S, Kolodny, Edwin H, Bilaniuk, Larissa T, Wang, Dah-Jyuu, Assadi, Mitra, Goldfarb, Olga, Goldman, H Warren, Freese, Andrew, Young, Deborah, During, Matthew J, Samulski, R Jude, Janson, Christopher G

“…Canavan disease is a hereditary leukodystrophy caused by mutations in the aspartoacylase gene (ASPA), leading to loss of enzyme activity and increased…”
Get more information

Xanthine oxidase inhibits growth of Plasmodium falciparum in human erythrocytes in vitro by BERMAN, P. A, HUMAN, L, FREESE, J. A

“…Malaria parasites, unable to synthesize purine de novo, use host-derived hypoxanthine preferentially as purine source. In a previous study (1990. J. Biol…”
Get full text

Prospects for gene therapy in Parkinson's disease by Freese, A, Stern, M, Kaplitt, M G, O'Connor, W M, Abbey, M V, O'Connor, M J, During, M J

“…Numerous advances in in vivo and ex vivo gene-therapy approaches to Parkinson's disease offer promise for direct clinical trials in patients in the next…”
Get more information