Search Results - "Freemont, A."

The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain by Freemont, A. J.

“…In 2007, three times as many peer reviewed publications covering the biology and biotherapeutics of intervertebral disc (IVD) disease appeared in the…”
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Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc by Hoyland, J. A., Le Maitre, C., Freemont, A. J.

“…Objective. To establish if IL-1 or TNF regulates matrix degradation in the non-degenerate or degenerate intervertebral disc (IVD). Methods. In situ zymography…”
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Matrix synthesis and degradation in human intervertebral disc degeneration by Le Maitre, C L, Pockert, A, Buttle, D J, Freemont, A J, Hoyland, J A

“…Degeneration of the intervertebral disc has been implicated in chronic low back pain. Type II collagen and proteoglycan (predominantly aggrecan) content is…”
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Morphology, mechanisms and pathology of musculoskeletal ageing by Freemont, AJ, Hoyland, JA

“…In general terms, the recognized alterations in circulating humoral factors (hormones, cytokines, growth factors) that occur in ageing, coupled with innate…”
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Nerve growth factor expression and innervation of the painful intervertebral disc by Freemont, A. J., Watkins, A., Le Maitre, C., Baird, P., Jeziorska, M., Knight, M. T. N., Ross, E. R. S., O'Brien, J. P., Hoyland, J. A.

“…Following a previous description of nociceptive nerve fibre growth into usually aneural inner parts of painful intervertebral disc (IVD), this study has…”
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Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy by Freemont, A. J., Watkins, A., Le Maitre, C., Jeziorska, M., Hoyland, J. A.

“…Until recently, material removed from the intervertebral disc (IVD) at surgery consisted either of ‘loose bodies’ from the centre of the IVD or discal tissue…”
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Isolation of a small molecule inhibitor of DNA base excision repair by Madhusudan, Srinivasan, Smart, Fiona, Shrimpton, Paul, Parsons, Jason L., Gardiner, Laurence, Houlbrook, Sue, Talbot, Denis C., Hammonds, Timothy, Freemont, Paul A., Sternberg, Michael J. E., Dianov, Grigory L., Hickson, Ian D.

“…The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation. A key step in BER is the processing of an…”
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Nerve ingrowth into diseased intervertebral disc in chronic back pain by Freemont, A J, Peacock, T E, Goupille, P, Hoyland, J A, O'Brien, J, Jayson, M I

“…In the healthy back only the outer third of the annulus fibrosus of the intervertebral disc is innervated. Nerve ingrowth deeper into diseased intervertebral…”
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Muscle regeneration following repair of the rotator cuff by Butt, U, Rashid, M S, Temperley, D, Crank, S, Birch, A, Freemont, A J, Trail, I A

“…The aim of this study was to analyse human muscle tissue before and after rotator cuff repair to look for evidence of regeneration, and to characterise the…”
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Acquisition of biologically relevant gene expression data by Affymetrix microarray analysis of archival formalin-fixed paraffin-embedded tumours by Linton, K M, Hey, Y, Saunders, E, Jeziorska, M, Denton, J, Wilson, C L, Swindell, R, Dibben, S, Miller, C J, Pepper, S D, Radford, J A, Freemont, A J

“…Robust protocols for microarray gene expression profiling of archival formalin-fixed paraffin-embedded tissue (FFPET) are needed to facilitate research when…”
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Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies by Richardson, S M, Mobasheri, A, Freemont, A J, Hoyland, J A

“…Degeneration of the intervertebral disc (IVD) is a major cause of low back pain affecting a large percentage of the population at some point in their lives…”
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Histopathological perspective on bone marrow oedema, reactive bone change and haemorrhage by Thiryayi, W.A, Thiryayi, S.A, Freemont, A.J

“…Abstract This article presents a systematic review of the current biomedical literature surrounding the aetiopathogenesis and histopathological features of…”
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Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific by Freemont, A J, Hampson, V, Tilman, R, Goupille, P, Taiwo, Y, Hoyland, J A

“…OBJECTIVES Matrix metalloproteinases (MMPs) are thought to be major mediators of cartilage destruction. Osteoarthritis (OA) is characterised by cartilage…”
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Low bone mineral density in adults with cystic fibrosis by Haworth, C S, Selby, P L, Webb, A K, Dodd, M E, Musson, H, Niven, R McL, Economou, G, Horrocks, A W, Freemont, A J, Mawer, E B, Adams, J E

“…BACKGROUND Patients with cystic fibrosis have several risk factors for the development of low bone mineral density (BMD). To identify the prevalence and…”
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Sarcoma in neurofibromatosis 2: case report and review of the literature by Linder, C., Smith, M. J., Bulman, M., Wallace, A., Freemont, A. J., Mangham, D. C., Evans, D. G. R.

“…Neurofibromatosis type 2 (NF2) is associated with the development of several types of benign nervous system tumours, while malignancies are rare. We report a…”
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Qualitative grading of disc degeneration by magnetic resonance in the lumbar and cervical spine: lack of correlation with histology in surgical cases by Davies, B. M., Atkinson, R. A., Ludwinski, F., Freemont, A. J., Hoyland, J. A., Gnanalingham, K. K.

“…Background: Clinically, magnetic resonance (MR) imaging is the most effective non-invasive tool for assessing IVD degeneration. Histological examination of the…”
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The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration by Le Maitre, Christine Lyn, Freemont, Anthony J, Hoyland, Judith Alison

“…In this study, we investigated the hypotheses that in human intervertebral disc (IVD) degeneration there is local production of the cytokine IL-1, and that…”
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Expression of osteonectin and matrix Gla protein in scleroderma patients with and without calcinosis by DAVIES, C. A, JEZIORSKA, M, FREEMONT, A. J, HERRICK, A. L

“…Our aim was to evaluate (i) whether the bone matrix proteins osteonectin and matrix gamma-carboxyglutamic acid protein (MGP) are up-regulated in skin biopsies…”
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The effects of lanthanum carbonate and calcium carbonate on bone abnormalities in patients with end-stage renal disease by Freemont, A J, Hoyland, J A, Denton, J

“…Renal osteodystrophy is a common complication of end-stage renal disease (ESRD) and is a major cause of morbidity in patients with ESRD. High serum levels of…”
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Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc by Le Maitre, Christine Lyn, Freemont, Anthony J, Hoyland, Judith Alison

“…The histological and biochemical changes that occur in the extracellular matrix of the intervertebral disc (IVD) during ageing and degeneration have been…”
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