Search Results - "Freeman, Luke"

Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition by Eggink, Florine A., Van Gool, Inge C., Leary, Alexandra, Pollock, Pamela M., Crosbie, Emma J., Mileshkin, Linda, Jordanova, Ekaterina S., Adam, Julien, Freeman-Mills, Luke, Church, David N., Creutzberg, Carien L., De Bruyn, Marco, Nijman, Hans W., Bosse, Tjalling

“…High-risk endometrial cancer (EC) is an aggressive disease for which new therapeutic options are needed. Aims of this study were to validate the enhanced…”
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POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer by van Gool, Inge C, Eggink, Florine A, Freeman-Mills, Luke, Stelloo, Ellen, Marchi, Emanuele, de Bruyn, Marco, Palles, Claire, Nout, Remi A, de Kroon, Cor D, Osse, Elisabeth M, Klenerman, Paul, Creutzberg, Carien L, Tomlinson, Ian Pm, Smit, Vincent Thbm, Nijman, Hans W, Bosse, Tjalling, Church, David N

“…Recent studies have shown that 7% to 12% of endometrial cancers are ultramutated due to somatic mutation in the proofreading exonuclease domain of the DNA…”
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Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche by Davis, Hayley, Irshad, Shazia, Bansal, Mukesh, Rafferty, Hannah, Boitsova, Tatjana, Bardella, Chiara, Jaeger, Emma, Lewis, Annabelle, Freeman-Mills, Luke, Giner, Francesc C, Rodenas-Cuadrado, Pedro, Mallappa, Sreelakshmi, Clark, Susan, Thomas, Huw, Jeffery, Rosemary, Poulsom, Richard, Rodriguez-Justo, Manuel, Novelli, Marco, Chetty, Runjan, Silver, Andrew, Sansom, Owen J, Greten, Florian R, Wang, Lai Mun, East, James E, Tomlinson, Ian, Leedham, Simon J

“…The authors report a mechanistic basis for intestinal polyp formation in patients with hereditary mixed polyposis syndrome that involves the aberrant…”
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Transmitting delusional beliefs in a hypnotic model of folie à deux by Freeman, Luke P., Cox, Rochelle E., Barnier, Amanda J.

“…•We used hypnosis to model transference of delusional beliefs from a “primary” to a “secondary” individual.•We manipulated the status of the primary to portray…”
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Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study by Domingo, Enric, Freeman-Mills, Luke, Rayner, Emily, Glaire, Mark, Briggs, Sarah, Vermeulen, Louis, Fessler, Evelyn, Medema, Jan Paul, Boot, Arnoud, Morreau, Hans, van Wezel, Tom, Liefers, Gerrit-Jan, Lothe, Ragnhild A, Danielsen, Stine A, Sveen, Anita, Nesbakken, Arild, Zlobec, Inti, Lugli, Alessandro, Koelzer, Viktor H, Berger, Martin D, Castellví-Bel, Sergi, Muñoz, Jenifer, de Bruyn, Marco, Nijman, Hans W, Novelli, Marco, Lawson, Kay, Oukrif, Dahmane, Frangou, Eleni, Dutton, Peter, Tejpar, Sabine, Delorenzi, Mauro, Kerr, Rachel, Kerr, David, Tomlinson, Ian, Church, David N

“…Precision cancer medicine depends on defining distinct tumour subgroups using biomarkers that may occur at very modest frequencies. One such subgroup comprises…”
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A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding by Lewis, Annabelle, Freeman-Mills, Luke, de la Calle-Mustienes, Elisa, Giráldez-Pérez, Rosa María, Davis, Hayley, Jaeger, Emma, Becker, Martin, Hubner, Nina C., Nguyen, Luan N., Zeron-Medina, Jorge, Bond, Gareth, Stunnenberg, Hendrik G., Carvajal, Jaime J., Gomez-Skarmeta, Jose Luis, Leedham, Simon, Tomlinson, Ian

“…A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC)…”
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Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism by Aughey, Gabriel N, Grice, Stuart J, Shen, Qing-Ji, Xu, Yichi, Chang, Chia-Chun, Azzam, Ghows, Wang, Pei-Yu, Freeman-Mills, Luke, Pai, Li-Mei, Sung, Li-Ying, Yan, Jun, Liu, Ji-Long

“…The essential metabolic enzyme CTP synthase (CTPsyn) can be compartmentalised to form an evolutionarily-conserved intracellular structure termed the…”
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Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis by Bardella, Chiara, Al-Dalahmah, Osama, Krell, Daniel, Brazauskas, Pijus, Al-Qahtani, Khalid, Tomkova, Marketa, Adam, Julie, Serres, Sébastien, Lockstone, Helen, Freeman-Mills, Luke, Pfeffer, Inga, Sibson, Nicola, Goldin, Robert, Schuster-Böeckler, Benjamin, Pollard, Patrick J., Soga, Tomoyoshi, McCullagh, James S., Schofield, Christopher J., Mulholland, Paul, Ansorge, Olaf, Kriaucionis, Skirmantas, Ratcliffe, Peter J., Szele, Francis G., Tomlinson, Ian

“…Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this…”
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Speech, silence, and slave descent in highland Madagascar by Freeman, Luke

“…This article is an examination of the uses and effects of words and silence. It analyses the rhetorical strategies used in connection with a fundamental…”
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Speech, silence, and slave descent in highland M adagascar by Freeman, Luke

“…This article is an examination of the uses and effects of words and silence. It analyses the rhetorical strategies used in connection with a fundamental…”
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Forest and Labor in Madagascar: From Colonial Concession to Global Biosphere by Genese Marie Sodikoff Bloomington, IN: Indiana University Press, 2012. Pp. 245. £17·99 (pbk) by FREEMAN, LUKE

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REVIEWS by FREEMAN, LUKE

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What Works to Increase Charitable Donations? A Meta-Review with Meta-Meta-Analysis by Saeri, Alexander K., Slattery, Peter, Lee, Joannie, Houlden, Thomas, Farr, Neil, Gelber, Romy L., Stone, Jake, Huuskes, Lee, Timmons, Shane, Windle, Kai, Spajic, Luke, Freeman, Luke, Moss, David, Behar, Jon, Schubert, Stefan, Grundy, Emily A. C., Zorker, Michael

“…Many charities rely on donations to support their work addressing some of the world’s most pressing problems. We conducted a meta-review to determine what…”
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EXABS-156-CML Beyond TKI Therapy in CML by Freeman-Mills, Luke, Copland, Mhairi

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COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study by Lee, Lennard YW, Cazier, Jean-Baptiste, Angelis, Vasileios, Arnold, Roland, Bisht, Vartika, Campton, Naomi A, Chackathayil, Julia, Cheng, Vinton WT, Curley, Helen M, Fittall, Matthew W, Freeman-Mills, Luke, Gennatas, Spyridon, Goel, Anshita, Hartley, Simon, Hughes, Daniel J, Kerr, David, Lee, Alvin JX, Lee, Rebecca J, McGrath, Sophie E, Middleton, Christopher P, Murugaesu, Nirupa, Newsom-Davis, Thomas, Okines, Alicia FC, Olsson-Brown, Anna C, Palles, Claire, Pan, Yi, Pettengell, Ruth, Powles, Thomas, Protheroe, Emily A, Purshouse, Karin, Sharma-Oates, Archana, Sivakumar, Shivan, Smith, Ashley J, Starkey, Thomas, Turnbull, Chris D, Várnai, Csilla, Yousaf, Nadia, Kerr, Rachel, Middleton, Gary

“…Individuals with cancer, particularly those who are receiving systemic anticancer treatments, have been postulated to be at increased risk of mortality from…”
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A Study of Short-Season Winter Cover Crops for Organic High Tunnel Production Systems by Freeman, Luke R

“…This two-year study investigated short-season winter cover crops to improve soil quality and growth of subsequent vegetable crops in an organic high tunnel…”
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The Music and Mathematics of Maximal Evenness in Graphs by Bushaw, Neal, Cody, Brent, Freeman, Luke, Whitaker, Tobias

“…Bridges Proceedings 2024, https://archive.bridgesmathart.org/2024/ We use the concept of electric potential energy from physics, the mathematical field of…”
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ANCESTOR CULTS IN IMERINA Madagascar: les ancêtres au quotidien – usages sociaux du religieux sur les Hautes-Terres Malgaches . By M ALANJAONA R AKOTOMALA , S OPHIE B LANCHY and F RANÇOISE R AISON -J OURDE . Paris: L'Harmattan, 2001. Pp. 522. No price given, paperback ( ISBN 2-7475-0019-5) by FREEMAN, LUKE

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Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis by Bardella, C., Al-Dalahmah, O., Krell, D., Brazauskas, P., Al-Qahtani, K., Tomkova, M., Adam, J., Serres, S., Lockstone, H., Freeman-Mills, L., Pfeffer, I., Sibson, N., Goldin, R., Schuster-Boeckler, B., Pollard, Patrick, Soga, T., McCullagh, J. S., Schofield, C. J., Mulholland, P., Ansorge, O., Kriaucionis, S., Ratcliffe, P. J., Szele, F. G., Tomlinson, I.

“…Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this…”
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A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS by Rosmarin, Dan, Palles, Claire, Pagnamenta, Alistair, Kaur, Kulvinder, Pita, Guillermo, Martin, Miguel, Domingo, Enric, Jones, Angela, Howarth, Kimberley, Freeman-Mills, Luke, Johnstone, Elaine, Wang, Haitao, Love, Sharon, Scudder, Claire, Julier, Patrick, Fernández-Rozadilla, Ceres, Ruiz-Ponte, Clara, Carracedo, Angel, Castellvi-Bel, Sergi, Castells, Antoni, Gonzalez-Neira, Anna, Taylor, Jenny, Kerr, Rachel, Kerr, David, Tomlinson, Ian

“…Capecitabine is an oral 5-fluorouracil (5-FU) pro-drug commonly used to treat colorectal carcinoma and other tumours. About 35% of patients experience…”
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