Search Results - "Freeman, Brian C."

Lysine Deacetylases Regulate the Heat Shock Response Including the Age-Associated Impairment of HSF1 by Zelin, Elena, Freeman, Brian C.

“…Heat shock factor 1 (HSF1) is critical for defending cells from both acute and chronic stresses. In aging cells, the DNA binding activity of HSF1 deteriorates…”
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Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation by Wang, Anqi, Kolhe, Janhavi A., Gioacchini, Nate, Baade, Imke, Brieher, William M., Peterson, Craig L., Freeman, Brian C.

“…Movement of chromosome sites within interphase cells is critical for numerous pathways including RNA transcription and genome organization. Yet, a mechanism…”
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Regulation of Protein Transport Pathways by the Cytosolic Hsp90s by Mankovich, Anna G, Freeman, Brian C

“…The highly conserved molecular chaperone heat shock protein 90 (Hsp90) is well-known for maintaining metastable proteins and mediating various aspects of…”
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Global Functional Map of the p23 Molecular Chaperone Reveals an Extensive Cellular Network by Echtenkamp, Frank J., Zelin, Elena, Oxelmark, Ellinor, Woo, Joyce I., Andrews, Brenda J., Garabedian, Michael, Freeman, Brian C.

“…In parallel with evolutionary developments, the Hsp90 molecular chaperone system shifted from a simple prokaryotic factor into an expansive network that…”
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The p23 Molecular Chaperone and GCN5 Acetylase Jointly Modulate Protein-DNA Dynamics and Open Chromatin Status by Zelin, Elena, Zhang, Yang, Toogun, Oyetunji A., Zhong, Sheng, Freeman, Brian C.

“…Cellular processes function through multistep pathways that are reliant on the controlled association and disassociation of sequential protein complexes. While…”
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Slowing Bacterial Translation Speed Enhances Eukaryotic Protein Folding Efficiency by Siller, Efraín, DeZwaan, Diane C., Anderson, John F., Freeman, Brian C., Barral, José M.

“…The mechanisms for de novo protein folding differ significantly between bacteria and eukaryotes, as evidenced by the often observed poor yields of native…”
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Physiological and Transcriptional Responses to Osmotic Stress of Two Pseudomonas syringae Strains That Differ in Epiphytic Fitness and Osmotolerance by Freeman, Brian C, Chen, Chiliang, Yu, Xilan, Nielsen, Lindsey, Peterson, Kelly, Beattie, Gwyn A

“…The foliar pathogen Pseudomonas syringae is a useful model for understanding the role of stress adaptation in leaf colonization. We investigated the…”
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Protocol for establishing a protein interactome based on close physical proximity to a target protein within live budding yeast by Kolhe, Janhavi A., Babu, Neethu L., Freeman, Brian C.

“…Here, we present a protocol for establishing a protein interactome based on close physical proximity to a target protein within live yeast cells. We describe…”
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Disassembly of Transcriptional Regulatory Complexes by Molecular Chaperones by Freeman, Brian C., Yamamoto, Keith R.

“…Many biological processes are initiated by cooperative assembly of large multicomponent complexes; however, mechanisms for modulating or terminating the…”
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Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase a by Sun, Jia, Yang, Yuting, Wan, Ke, Mao, Ninghui, Yu, Tai-yuan, Lin, Yi-chien, Dezwaan, Diane C, Freeman, Brian C, Lin, Jing-jer, Lue, Neal F, Lei, Ming

“…Budding yeast Cdc13-Stnl-Tenl （CST） complex plays an essential role in telomere protection and maintenance, and has been proposed to be a telomere-specific…”
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Is the duration of pre-operative conservative treatment associated with the clinical outcome following surgical decompression for lumbar spinal stenosis? A study based on the Spine Tango Registry by Zweig, Thomas, Enke, Juliane, Mannion, Anne F., Sobottke, Rolf, Melloh, Markus, Freeman, Brian J. C., Aghayev, Emin

“…Background The incidence of lumbar spinal stenosis (LSS) continues to rise, with both conservative and surgical management representing options for its…”
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HSP90: The Rosetta stone for cellular protein dynamics? by DeZwaan, Diane C., Freeman, Brian C.

“…The Hsp90 proteomic network is expansive and includes a variety of cell processes operating within the cytoplasm and nucleoplasm. Though the functional…”
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The Hsp90 Molecular Chaperone Modulates Multiple Telomerase Activities by Toogun, Oyetunji A., DeZwaan, Diane C., Freeman, Brian C.

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Bacterial Growth Restriction During Host Resistance to Pseudomonas syringae Is Associated with Leaf Water Loss and Localized Cessation of Vascular Activity in Arabidopsis thaliana by FREEMAN, Brian C, BEATTIE, Gwyn A

“…The physiological mechanisms by which plants limit the growth of bacterial pathogens during gene-for-gene resistance are poorly understood. We characterized…”
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p23/Sba1p Protects against Hsp90 Inhibitors Independently of Its Intrinsic Chaperone Activity by Forafonov, Fedor, Toogun, Oyetunji A., Grad, Iwona, Suslova, Elena, Freeman, Brian C., Picard, Didier

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2009 ISSLS Prize Winner: What Influence Does Sustained Mechanical Load Have on Diffusion in the Human Intervertebral Disc?: An In Vivo Study Using Serial Postcontrast Magnetic Resonance Imaging by ARUN, Ranganathan, FREEMAN, Brian J. C, SCAMMELL, Brigitte E, MCNALLY, Donal S, COX, Eleanor, GOWLAND, Penny

“…An in vivo study of the effects of mechanical loading on transport of small solutes into normal human lumbar intervertebral discs (IVD) using serial…”
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Establishing Order Through Disorder by the Hsp90 Molecular Chaperone by Babu, Neethu, Freeman, Brian C.

“…[Display omitted] •Hsp90 is a key molecular chaperone player in eukaryotic proteostasis systems.•Hsp90 contributes to proteostasis by folding, stabilizing, and…”
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Molecular chaperone-mediated nuclear protein dynamics by Echtenkamp, Frank J, Freeman, Brian C

“…Homeostasis requires effective action of numerous biological pathways including those working along a genome. The variety of processes functioning in the…”
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A randomized, double-blind, controlled trial : Intradiscal electrothermal therapy Versus placebo for the treatment of chronic discogenic low back pain by FREEMAN, Brian J. C, FRASOR, Robert D, CAIN, Christopher M. J, HALL, David J, CHAPPLE, David C. L, CAREY, Timothy S

“…A prospective, randomized, double-blind, placebo-controlled trial of intradiscal electrothermal therapy (IDET) for the treatment of chronic discogenic low back…”
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conserved Est1 protein stimulates telomerase DNA extension activity by DeZwaan, Diane C, Freeman, Brian C

“…The first telomerase cofactor identified was the budding yeast protein Est1, which is conserved through humans. While it is evident that Est1 is required for…”
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