Search Results - "Freels, Timothy G"

Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit by Molas, Susanna, Freels, Timothy G., Zhao-Shea, Rubing, Lee, Timothy, Gimenez-Gomez, Pablo, Barbini, Melanie, Martin, Gilles E., Tapper, Andrew R.

“…Animals are inherently motivated to explore social novelty cues over familiar ones, resulting in a novelty preference (NP), although the behavioral and circuit…”
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Cannabis vapor self-administration elicits sex- and dose-specific alterations in stress reactivity in rats by Glodosky, Nicholas C., Cuttler, Carrie, Freels, Timothy G., Wright, Hayden R., Rojas, Manuel J., Baglot, Samantha L., Hill, Matthew N., McLaughlin, Ryan J.

“…Cannabis users frequently report stress relief as their primary reason for use. Recent studies indicate that human cannabis users exhibit blunted stress…”
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Dynamic activity of interpeduncular nucleus GABAergic neurons controls expression of nicotine withdrawal in male mice by Klenowski, Paul M, Zhao-Shea, Rubing, Freels, Timothy G, Molas, Susanna, Tapper, Andrew R

“…A critical brain area implicated in nicotine dependence is the interpeduncular nucleus (IPN) located in the ventral midbrain and consisting primarily of…”
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Risky decision-making predicts dopamine release dynamics in nucleus accumbens shell by Freels, Timothy G, Gabriel, Daniel B K, Lester, Deranda B, Simon, Nicholas W

“…The risky decision-making task (RDT) measures risk-taking in a rat model by assessing preference between a small, safe reward and a large reward with…”
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Risky decision-making is associated with impulsive action and sensitivity to first-time nicotine exposure by Gabriel, Daniel B.K., Freels, Timothy G., Setlow, Barry, Simon, Nicholas W.

“…•The rat risky decision-making task reveals widespread variability in performance.•Risk-taking rats exhibit elevated impulsive action, but not impulsive…”
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Vaporized cannabis extract–induced antinociception in male vs female rats with persistent inflammatory pain by Craft, Rebecca M., Gogulski, Hannah Y., Freels, Timothy G., Glodosky, Nicholas C., McLaughlin, Ryan J.

“…Although preclinical studies generally report robust antinociceptive effects of cannabinoids in rodent persistent pain models, randomized controlled trials in…”
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Arachidonoyl serotonin (AA-5-HT) modulates general fear-like behavior and inhibits mesolimbic dopamine release by Freels, Timothy G., Lester, Deranda B., Cook, Melloni N.

“…•AA-5-HT enhanced rearing and locomotor activity in the OF in BCJ mice.•AA-5-HT inhibited general fear in B6 mice.•AA-5-HT and ACEA inhibited dopamine release…”
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Vaporized Cannabis Extracts Have Reinforcing Properties and Support Conditioned Drug-Seeking Behavior in Rats by Freels, Timothy G, Baxter-Potter, Lydia N, Lugo, Janelle M, Glodosky, Nicholas C, Wright, Hayden R, Baglot, Samantha L, Petrie, Gavin N, Yu, Zhihao, Clowers, Brian H, Cuttler, Carrie, Fuchs, Rita A, Hill, Matthew N, McLaughlin, Ryan J

“…Recent trends in cannabis legalization have increased the necessity to better understand the effects of cannabis use. Animal models involving traditional…”
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Systemic oxytocin administration alters mesolimbic dopamine release in mice by Estes, Mary K., Freels, Timothy G., Prater, William T., Lester, Deranda B.

“…Growing research indicates oxytocin may be involved in relieving anxiety and attenuating the rewarding effects of psychostimulants. This study investigated the…”
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Long-term effects of maternal cannabis vapor exposure on emotional reactivity, social behavior, and behavioral flexibility in offspring by Weimar, Halle V., Wright, Hayden R., Warrick, Collin R., Brown, Amanda M., Lugo, Janelle M., Freels, Timothy G., McLaughlin, Ryan J.

“…The use of cannabis during pregnancy is a growing public health concern. As more countries implement legislation permitting recreational cannabis use, there is…”
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Indirect and Direct Cannabinoid Agonists Differentially Affect Mesolimbic Dopamine Release and Related Behaviors by Honeywell, Kevin M., Freels, Timothy G., McWain, Megan A., Chaffin, Abigail S., Nolen, Hunter G., Sable, Helen J., Lester, Deranda B.

“…The cannabinoid system is being researched as a potential pharmaceutical target for a multitude of disorders. The present study examined the effect of indirect…”
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Dopamine receptors regulate preference between high-effort and high-risk rewards by Gabriel, Daniel B. K., Liley, Anna E., Freels, Timothy G., Simon, Nicholas W.

“…Rationale Optimal decision-making necessitates evaluation of multiple rewards that are each offset by distinct costs, such as high effort requirement or high…”
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Comparing phasic dopamine dynamics in the striatum, nucleus accumbens, amygdala, and medial prefrontal cortex by Holloway, Zade R., Freels, Timothy G., Comstock, Josiah F., Nolen, Hunter G., Sable, Helen J., Lester, Deranda B.

“…Midbrain dopaminergic neurons project to and modulate multiple highly interconnected modules of the basal ganglia, limbic system, and frontal cortex. Dopamine…”
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Viral Tracing Confirms Paranigral Ventral Tegmental Area Dopaminergic Inputs to the Interpeduncular Nucleus Where Dopamine Release Encodes Motivated Exploration by Molas, Susanna, Zhao-Shea, Rubing, Freels, Timothy G, Tapper, Andrew R

“…Midbrain dopaminergic (DAergic) neurons of the ventral tegmental area (VTA) are engaged by rewarding stimuli and encode reward prediction error to update…”
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A neuronal coping mechanism linking stress-induced anxiety to motivation for reward by Klenowski, Paul M, Zhao-Shea, Rubing, Freels, Timothy G, Molas, Susanna, Zinter, Max, M'Angale, Peter, Xiao, Cong, Martinez-Núñez, Leonora, Thomson, Travis, Tapper, Andrew R

“…Stress coping involves innate and active motivational behaviors that reduce anxiety under stressful situations. However, the neuronal bases directly linking…”
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Sex Differences in Response-Contingent Cannabis Vapor Administration During Adolescence Mediate Enduring Effects on Behavioral Flexibility and Prefrontal Microglia Activation in Rats by Freels, Timothy G, Westbrook, Sara R, Zamberletti, Erica, Kuyat, Jacqulyn R, Wright, Hayden R, Malena, Alexandra N, Melville, Max W, Brown, Amanda M, Glodosky, Nicholas C, Ginder, Darren E, Klappenbach, Courtney M, Delevich, Kristen M, Rubino, Tiziana, McLaughlin, Ryan J

“…Cannabis is the most used illicit drug in the United States. With many states passing legislation to permit its recreational use, there is concern that…”
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Anxiety: Involvement of Cannabinergic Signaling and Cross-Talk With Serotonergic and Opioidergic Pathways by Freels, Timothy G, Cook, Melloni N

“…Anxiety-related disorders are common in the United States. Anxiety symptoms are treated with benzodiazepines and antidepressants; however, these drugs produce…”
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