Search Results - "Freel Meyers, Caren L."

GDE2 Promotes Neurogenesis by Glycosylphosphatidylinositol-Anchor Cleavage of RECK by Park, Sungjin, Lee, Changhee, Sabharwal, Priyanka, Zhang, Mei, Meyers, Caren L. Freel, Sockanathan, Shanthini

“…The six-transmembrane protein glycerophosphodiester phosphodiesterase 2 (GDE2) induces spinal motor neuron differentiation by inhibiting Notch signaling in…”
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Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV by Rajoli, Rajith K. R., Back, David J., Rannard, Steve, Freel Meyers, Caren L., Flexner, Charles, Owen, Andrew, Siccardi, Marco

“…Background and Objectives Antiretrovirals are currently used for the treatment and prevention of HIV infection. However, poor adherence and low tolerability of…”
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Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors by Sanders, Sara, Bartee, David, Harrison, Mackenzie J, Phillips, Paul D, Koppisch, Andrew T, Freel Meyers, Caren L

“…The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions…”
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DXP Synthase Function in a Bacterial Metabolic Adaptation and Implications for Antibacterial Strategies by Chen, Eric C, Freel Meyers, Caren L

“…Pathogenic bacteria possess a remarkable ability to adapt to fluctuating host environments and cause infection. Disturbing bacterial central metabolism through…”
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Pharmacological activation of myosin II paralogs to correct cell mechanics defects by Surcel, Alexandra, Ng, Win Pin, West-Foyle, Hoku, Zhu, Qingfeng, Ren, Yixin, Avery, Lindsay B., Krenc, Agata K., Meyers, David J., Rock, Ronald S., Anders, Robert A., Meyers, Caren L. Freel, Robinson, Douglas N.

“…Significance Despite the integral role of cell mechanics, efforts to target mechanics for drug development have lagged. Here, we present an approach to…”
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Toward Understanding the Chemistry and Biology of 1‑Deoxy‑d‑xylulose 5‑Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism by Bartee, David, Freel Meyers, Caren L

“…Conspectus Antibiotics are the cornerstone of modern healthcare. The 20th century discovery of sulfonamides and β-lactam antibiotics altered human society…”
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Aldehyde-based activation of C2α-lactylthiamin diphosphate decarboxylation on bacterial 1-deoxy-d-xylulose 5-phosphate synthase by Toci, Eucolona M, Majumdar, Ananya, Freel Meyers, Caren L

“…1-Deoxy-d-xylulose 5-phosphate synthase (DXPS) catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from pyruvate (donor substrate) and…”
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Targeting the Unique Mechanism of Bacterial 1‑Deoxy‑d‑xylulose-5-phosphate Synthase by Bartee, David, Freel Meyers, Caren L

“…The bacterial metabolite 1-deoxy-d-xyulose 5-phosphate (DXP) is essential in bacterial central metabolism feeding into isoprenoid, thiamin diphosphate (ThDP),…”
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Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism by Johnston, Melanie L, Freel Meyers, Caren L

“…The thiamin diphosphate-dependent enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) catalyzes the formation of DXP from pyruvate (donor) and…”
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Targeting DXP synthase in human pathogens: enzyme inhibition and antimicrobial activity of butylacetylphosphonate by Smith, Jessica M, Warrington, Nicole V, Vierling, Ryan J, Kuhn, Misty L, Anderson, Wayne F, Koppisch, Andrew T, Freel Meyers, Caren L

“…The unique methylerythritol phosphate pathway for isoprenoid biosynthesis is essential in most bacterial pathogens. The first enzyme in this pathway, 1-deoxy-…”
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Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines by Webster, Marie R, Kamat, Chandrashekhar, Connis, Nick, Zhao, Ming, Weeraratna, Ashani T, Rudek, Michelle A, Hann, Christine L, Freel Meyers, Caren L

“…Bisphosphonates are used clinically to treat disorders of calcium metabolism and malignant bone disease and are known to inhibit cancer cell growth, adhesion,…”
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IspG-Catalyzed Positional Isotopic Exchange in Methylerythritol Cyclodiphosphate of the Deoxyxylulose Phosphate Pathway: Mechanistic Implications by Xiao, Youli, Rooker, Debra, You, Quincy, Freel Meyers, Caren L, Liu, Pinghua

“…H218O under the bridge: Recently, the deoxyxylulose phosphate (DXP) pathway was discovered to be a second pathway supplying isoprenoid biosynthetic precursors…”
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Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2‑C‑Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens by Bartee, David, Wheadon, Michael J, Freel Meyers, Caren L

“…Targeting essential bacterial processes beyond cell wall, protein, nucleotide, and folate syntheses holds promise to reveal new antimicrobial agents and expand…”
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X-ray crystallography–based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate by Chen, Percival Yang-Ting, DeColli, Alicia A., Freel Meyers, Caren L., Drennan, Catherine L.

“…1-Deoxy-d-xylulose 5-phosphate synthase (DXPS) uses thiamine diphosphate (ThDP) to convert pyruvate and d-glyceraldehyde 3-phosphate (d-GAP) into…”
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Active Site Histidines Link Conformational Dynamics with Catalysis on Anti-Infective Target 1‑Deoxy‑d‑xylulose 5‑Phosphate Synthase by DeColli, Alicia A, Zhang, Xu, Heflin, Kathryn L, Jordan, Frank, Freel Meyers, Caren L

“…The product of 1-deoxy-d-xyluose 5-phosphate (DXP) synthase, DXP, feeds into the bacterial biosynthesis of isoprenoids, thiamin diphosphate (ThDP), and…”
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Antibacterial Target DXP Synthase Catalyzes the Cleavage of d‑Xylulose 5‑Phosphate: a Study of Ketose Phosphate Binding and Ketol Transfer Reaction by Johnston, Melanie L., Toci, Eucolona M., DeColli, Alicia A., Freel Meyers, Caren L.

“…The bacterial enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) catalyzes the formation of DXP from pyruvate and d-glyceraldehyde 3-phosphate (d-GAP) in a…”
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Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria by DeColli, Alicia A., Nemeria, Natalia S., Majumdar, Ananya, Gerfen, Gary J., Jordan, Frank, Freel Meyers, Caren L.

“…The underexploited antibacterial target 1-deoxy-d-xyluose 5-phosphate (DXP) synthase catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from…”
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Observation of Thiamin-Bound Intermediates and Microscopic Rate Constants for Their Interconversion on 1‑Deoxy‑d‑xylulose 5‑Phosphate Synthase: 600-Fold Rate Acceleration of Pyruvate Decarboxylation by d‑Glyceraldehyde-3-phosphate by Patel, Hetalben, Nemeria, Natalia S, Brammer, Leighanne A, Freel Meyers, Caren L, Jordan, Frank

“…The thiamin diphosphate (ThDP)-dependent enzyme 1-deoxy-d-xylulose 5-phosphate (DXP) synthase carries out the condensation of pyruvate as a 2-hydroxyethyl…”
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An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme by Coco, Lauren B, Freel Meyers, Caren L

“…This work reports an alkyl acetylphosphonate (alkylAP) activity-based probe (ABP) for 1-deoxy-d-xylulose 5-phosphate synthase DXPS, a promising antimicrobial…”
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Defining critical residues for substrate binding to 1‐deoxy‐d‐xylulose 5‐phosphate synthase – active site substitutions stabilize the predecarboxylation intermediate C2α‐lactylthiamin diphosphate by Brammer Basta, Leighanne A., Patel, Hetalben, Kakalis, Lazaros, Jordan, Frank, Freel Meyers, Caren L.

“…1‐Deoxy‐d‐xylulose 5‐phosphate (DXP) synthase catalyzes the formation of DXP from pyruvate and d‐glyceraldehyde 3‐phosphate (GraP) in a thiamin…”
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