Search Results - "Freel, E M"

Aldosterone status associated with insulin resistance in patients with heart failure--data from the ALOFT study by Freel, E M, Tsorlalis, I K, Lewsey, J D, Latini, R, Maggioni, A P, Solomon, S, Pitt, B, Connell, J M C, McMurray, J J V

“…Aldosterone has a key role in the pathophysiology of heart failure. In around 50% of such patients, aldosterone "escapes" from inhibition by drugs that…”
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Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects by Freel, E. M., Ingram, M., Wallace, A. M., White, A., Fraser, R., Davies, E., Connell, J. M. C.

“…Summary Background  Aldosterone is important in the development of hypertension. We have shown that a single nucleotide polymorphism (SNP) (–344T) in the 5′…”
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Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study by Freel, E. M., Ingram, M., Friel, E. C., Fraser, R., Brown, M., Samani, N. J., Caulfield, M., Munroe, P., Farrall, M., Webster, J., Clayton, D., Dominiczak, A. F., Davies, E., Connell, J. M. C.

“…Summary Background  Aldosterone is an important cardiovascular hormone; 15% of hypertensive subjects have alteration in aldosterone regulation, defined by a…”
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Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy by Freel, E. M., Bernhardt, M., Ingram, R., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M. C.

“…Summary Objective  Corticosteroids can be synthesized in extra‐adrenal tissues but the contribution of this to circulating levels in humans is not known…”
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Management of metastatic phaeochromocytoma and paraganglioma: use of iodine-131-meta-iodobenzylguanidine therapy in a tertiary referral centre by Rutherford, M A, Rankin, A J, Yates, T M, Mark, P B, Perry, C G, Reed, N S, Freel, E M

“…Phaeochromocytoma (phaeo) and paraganglioma (PGL) are rare conditions, which are malignant in up to 30%. Optimal treatment is controversial, but in patients…”
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Plasma steroid profiling and response to trophins to illustrate intra-adrenal dynamics by McManus, F, Fraser, R, Davies, E, Connell, J M C, Freel, E M

“…The importance of corticosteroids in cardiovascular and other chronic disease is recognised. In addition, plasma steroid precursor-to-product ratios are useful…”
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Alterations in vascular function in primary aldosteronism: a cardiovascular magnetic resonance imaging study by Mark, P B, Boyle, S, Zimmerli, L U, McQuarrie, E P, Delles, C, Freel, E M

“…Excess aldosterone is associated with increased cardiovascular risk. Aldosterone has a permissive effect on vascular fibrosis. Cardiovascular magnetic…”
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Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus by Diver, Louise A, MacKenzie, Scott M, Fraser, Robert, McManus, Frances, Freel, E Marie, Alvarez-Madrazo, Samantha, McClure, John D, Friel, Elaine C, Hanley, Neil A, Dominiczak, Anna F, Caulfield, Mark J, Munroe, Patricia B, Connell, John M, Davies, Eleanor

“…Genome-wide association studies implicate the CYP17A1 gene in human blood pressure regulation although the causative polymorphisms are as yet unknown. We…”
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Mechanisms of hypertension: the expanding role of aldosterone by Freel, E Marie, Connell, John M C

“…Hypertension is a common disorder that affects a large heterogeneous patient population. Subgroups can be identified on the basis of their responses to…”
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Hypertension by McManus, F, Freel, E M, Connell, J M C

“…Hypertension is a common condition affecting one in four adults. It is a leading cause of cardiovascular morbidity and mortality and appropriate treatment…”
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Endogenous corticosteroid biosynthesis in subjects after bilateral adrenalectomy by Freel, E. M., Bernhardt, M., Ingram, R., Wallace, A. M., Fraser, R., Davies, E., Connell, J. M. C.

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Modulation of iron-regulatory protein (IRP) activity in monocytes by nitric oxide, phorbol ester and gamma-interferon by Brock, J H, Bhandari, S, Freel, E M

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Studies on the Origin of Circulating 18-Hydroxycortisol and 18-Oxocortisol in Normal Human Subjects by Freel, E. Marie, Shakerdi, Loai A., Friel, Elaine C., Wallace, A. Michael, Davies, Eleanor, Fraser, Robert, Connell, John M. C.

“…18-Hydroxycortisol (18-OHF) and 18-oxocortisol (18-oxoF) are derivatives of cortisol found in primary aldosteronism but whose origin and regulation in normal…”
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Diagnosis of adenomatous primary aldosteronism in a patient with severe hypertension by Connell, John MC, Freel, E Marie

“…A 27-year-old woman presented to her primary-care physician with severe hypertension after complaining of fatigue over the preceding months. She was otherwise…”
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