Search Results - "Freedman, R. B."

Bioinspired mechanically active adhesive dressings to accelerate wound closure by Blacklow, S O, Li, J, Freedman, B R, Zeidi, M, Chen, C, Mooney, D J

“…Inspired by embryonic wound closure, we present mechanically active dressings to accelerate wound healing. Conventional dressings passively aid healing by…”
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Supraspinatus Tendons Have Different Mechanical Properties Across Sex by Bonilla, K A, Pardes, A M, Freedman, B R, Soslowsky, L J

“…Sex differences in the mechanical properties of different musculoskeletal tissues and their impact on tendon function and disease are becoming increasingly…”
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Aging leads to inferior Achilles tendon mechanics and altered ankle function in rodents by Pardes, A.M, Beach, Z.M, Raja, H, Rodriguez, A.B, Freedman, B.R, Soslowsky, L.J

“…Abstract Spontaneous rupture of the Achilles tendon is increasingly common in the middle aged population. However, the cause for the particularly high…”
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Males have Inferior Achilles Tendon Material Properties Compared to Females in a Rodent Model by Pardes, A. M., Freedman, B. R., Fryhofer, G. W., Salka, N. S., Bhatt, P. R., Soslowsky, L. J.

“…The Achilles tendon is the most commonly ruptured tendon in the human body. Numerous studies have reported incidence of these injuries to be upwards of five…”
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Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model by Gordon, J.A, Freedman, B.R, Zuskov, A, Iozzo, R.V, Birk, D.E, Soslowsky, L.J

“…Abstract Achilles tendons are a common source of pain and injury, and their pathology may originate from aberrant structure function relationships. Small…”
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Inhibition of HIV-1 protease: the rigidity perspective by Heal, J. W., Jimenez-Roldan, J. E., Wells, S. A., Freedman, R. B., Römer, R. A.

“…Motivation: HIV-1 protease is a key drug target due to its role in the life cycle of the HIV-1 virus. Rigidity analysis using the software First is a…”
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Ground reaction forces are more sensitive gait measures than temporal parameters in rodents following rotator cuff injury by Pardes, A.M, Freedman, B.R, Soslowsky, L.J

“…Abstract Gait analysis is a quantitative, non-invasive technique that can be used to investigate functional changes in animal models of musculoskeletal…”
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Tough Adhesive Hydrogel for Intraoral Adhesion and Drug Delivery by Wu, D.T., Freedman, B.R., Vining, K.H., Cuylear, D.L., Guastaldi, F.P.S., Levin, Y., Mooney, D.J.

“…Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are common chronic inflammatory conditions, manifesting as painful oral lesions that…”
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Protein disulfide isomerase: multiple roles in the modification of nascent secretory proteins by Freedman, R B

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The Disassembly and Reassembly of Mutants of Escherichia Coli Heat-Labile Enterotoxin:  Replacement of Proline 93 Does Not Abolish the Reassembly-Competent and Reassembly-Incompetent States by Cheesman, C, Freedman, R. B, Ruddock, L. W

“…The carrier moiety of heat-labile enterotoxin of Escherichia coli (EtxB) is formed by the noncovalent association of identical monomeric subunits, which…”
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Anti-inflammatory therapy enables robot-actuated regeneration of aged muscle by McNamara, S L, Seo, B R, Freedman, B R, Roloson, E B, Alvarez, J T, O'Neill, C T, Vandenburgh, H H, Walsh, C J, Mooney, D J

“…Robot-actuated mechanical loading (ML)-based therapies ("mechanotherapies") can promote regeneration after severe skeletal muscle injury, but the effectiveness…”
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The Refolding and Reassembly of Escherichia Coli Heat-Labile Enterotoxin B-Subunit:  Analysis of Reassembly-Competent and Reassembly-Incompetent Unfolded States by Cheesman, C, Ruddock, L. W, Freedman, R. B

“…The B-subunit pentamer of Escherichia coli heat-labile enterotoxin (EtxB) is an exceptionally stable protein maintaining its quaternary structure over the pH…”
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The reactivities and ionization properties of the active-site dithiol groups of mammalian protein disulphide-isomerase by HAWKINS, H. C, FREEDMAN, R. B

“…1. The number of reactive thiol groups in mammalian liver protein disulphide-isomerase (PDI) in various conditions was investigated by alkylation with…”
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Erratum to: Males have Inferior Achilles Tendon Material Properties Compared to Females in a Rodent Model by Pardes, A. M., Freedman, B. R., Fryhofer, G. W., Salka, N. S., Bhatt, P. R., Soslowsky, L. J.

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Specificity in substrate binding by protein folding catalysts: Tyrosine and tryptophan residues are the recognition motifs for the binding of peptides to the pancreas-specific protein disulfide isomerase PDIp by RUDDOCK, LLOYD W., FREEDMAN, ROBERT B., KLAPPA, PETER

“…Using a cross-linking approach, we recently demonstrated that radiolabeled peptides or misfolded proteins specifically interact in vitro with two luminal…”
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Rapid simulation of protein motion: merging flexibility, rigidity and normal mode analyses by Jimenez-Roldan, J E, Freedman, R B, Römer, R A, Wells, S A

“…Protein function frequently involves conformational changes with large amplitude on timescales which are difficult and computationally expensive to access…”
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The pancreas-specific protein disulphide-isomerase PDIp interacts with a hydroxyaryl group in ligands by Klappa, P, Freedman, R B, Langenbuch, M, Lan, M S, Robinson, G K, Ruddock, L W

“…Using a cross-linking approach, we have recently demonstrated that radiolabelled model peptides or misfolded proteins specifically interact in vitro with two…”
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Comparison of the activities of protein disulphide-isomerase and thioredoxin in catalysing disulphide isomerization in a protein substrate by HAWKINS, H. C, BLACKBURN, E. C, FREEDMAN, R. B

“…1. The activities of protein disulphide-isomerase (PDI) and thioredoxin in catalysing disulphide bond isomerization in a protein substrate were compared by…”
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The influence of His94 and Pro149 in modulating the activity of V. cholerae DsbA by Blank, J, Kupke, T, Lowe, E, Barth, P, Freedman, R B, Ruddock, L W

“…DsbA is the primary catalyst of disulfide bond formation in the periplasm of gram-negative bacteria. Numerous theoretical and experimental studies have been…”
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A molecular model for the redox potential difference between thioredoxin and DsbA, based on electrostatics calculations by Gane, P.J., Freedman, R.B., Warwicker, J.

“…The disulphide active sites of thioredoxin and DsbA are known to possess a high degree of structural homology. However, DsbA is a much stronger oxidant than…”
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