Search Results - "Freedman, Jonathan H"

HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection by Zhang, Jian, Xu, Zheng, Gu, Junlian, Jiang, Saizhi, Liu, Quan, Zheng, Yang, Freedman, Jonathan H, Sun, Jian, Cai, Lu

“…Vascular complications are common pathologies associated with type 1 diabetes. In recent years, histone deacetylation enzyme (HDAC) inhibitors have been shown…”
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Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity by Behl, Mamta, Hsieh, Jui-Hua, Shafer, Timothy J, Mundy, William R, Rice, Julie R, Boyd, Windy A, Freedman, Jonathan H, Hunter, E. Sidney, Jarema, Kimberly A, Padilla, Stephanie, Tice, Raymond R

“…Abstract Due to their toxicity and persistence in the environment, brominated flame retardants (BFRs) are being phased out of commercial use, leading to the…”
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Chronic exposure to arsenic and high fat diet induces sex-dependent pathogenic effects on the kidney by Zhang, Yixian, Young, Jamie L., Cai, Lu, Tong, Yong Guang, Miao, Lining, Freedman, Jonathan H.

“…Both obesity and arsenic exposure are global public health problems that are associated with increased risk of renal disease. The effect of whole-life exposure…”
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Induction of Plac8 promotes pro-survival function of autophagy in cadmium-induced prostate carcinogenesis by Kolluru, Venkatesh, Pal, Deeksha, Papu John, A.M. Sashi, Ankem, Murali K., Freedman, Jonathan H., Damodaran, Chendil

“…Chronic exposure to cadmium is known to be a risk factor for human prostate cancer. Despite over-whelming evidence of cadmium causing carcinogenicity in…”
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Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation by Ohja, Kshama, Gozal, Evelyne, Fahnestock, Margaret, Cai, Lu, Cai, Jun, Freedman, Jonathan H., Switala, Andy, El-Baz, Ayman, Barnes, Gregory Neal

“…Autism spectrum disorders (ASD) are the most prevalent set of pediatric neurobiological disorders. The etiology of ASD has both genetic and environmental…”
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Specificity and Complexity of the Caenorhabditis elegans Innate Immune Response by Alper, Scott, McBride, Sandra J., Lackford, Brad, Freedman, Jonathan H., Schwartz, David A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity by Cui, Yuxia, McBride, Sandra J, Boyd, Windy A, Alper, Scott, Freedman, Jonathan H

“…Exposure to cadmium is associated with a variety of human diseases. At low concentrations, cadmium activates the transcription of stress-responsive genes,…”
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Global transcriptome and deletome profiles of yeast exposed to transition metals by Jin, Yong Hwan, Dunlap, Paul E, McBride, Sandra J, Al-Refai, Hanan, Bushel, Pierre R, Freedman, Jonathan H

“…A variety of pathologies are associated with exposure to supraphysiological concentrations of essential metals and to non-essential metals and metalloids. The…”
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Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species by Hall, Julie A, McElwee, Matthew K, Freedman, Jonathan H

“…It has been proposed that aging results from the lifelong accumulation of intracellular damage via reactions with reactive oxygen species (ROS)…”
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Medium- and high-throughput screening of neurotoxicants using C. elegans by Boyd, Windy A, Smith, Marjolein V, Kissling, Grace E, Freedman, Jonathan H

“…Abstract The U.S. National Toxicology Program, the U.S. Environmental Protection Agency, and other national and international agencies are committing…”
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The Caenorhabditis elegans Germ Line Regulates Distinct Signaling Pathways to Control Lifespan and Innate Immunity by Alper, Scott, McElwee, Matthew K., Apfeld, Javier, Lackford, Brad, Freedman, Jonathan H., Schwartz, David A.

“…The relationship between the mechanisms that control an organism's lifespan and its ability to respond to environmental challenges are poorly understood. In…”
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Wildfires and climate justice: future wildfire events predicted to disproportionally impact socioeconomically vulnerable communities in North Carolina by Winker, Raquel, Payton, Alexis, Brown, Eric, McDermott, Elena, Freedman, Jonathan H, Lenhardt, Chris, Eaves, Lauren A, Fry, Rebecca C, Rager, Julia E

“…Wildfire events are becoming increasingly common across many areas of the United States, including North Carolina (NC). Wildfires can cause immediate damage to…”
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Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper by Song, Min Ok, Li, Jianying, Freedman, Jonathan H

“…1 Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North…”
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The application of natural language processing for the extraction of mechanistic information in toxicology by Corradi, Marie, Luechtefeld, Thomas, de Haan, Alyanne M, Pieters, Raymond, Freedman, Jonathan H, Vanhaecke, Tamara, Vinken, Mathieu, Teunis, Marc

“…To study the ways in which compounds can induce adverse effects, toxicologists have been constructing Adverse Outcome Pathways (AOPs). An AOP can be considered…”
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DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts by Braithwaite, Elena K, Kedar, Padmini S, Stumpo, Deborah J, Bertocci, Barbara, Freedman, Jonathan H, Samson, Leona D, Wilson, Samuel H

“…Base excision repair (BER) is a DNA repair pathway designed to correct small base lesions in genomic DNA. While DNA polymerase beta (pol beta) is known to be…”
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Cadmium Induces Retinoic Acid Signaling by Regulating Retinoic Acid Metabolic Gene Expression by Cui, Yuxia, Freedman, Jonathan H.

“…The transition metal cadmium is an environmental teratogen. In addition, cadmium and retinoic acid can act synergistically to induce forelimb malformations…”
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Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet by Mazzocco, John C., Jagadapillai, Rekha, Gozal, Evelyne, Kong, Maiying, Xu, Qian, Barnes, Gregory N., Freedman, Jonathan H.

“…[Display omitted] •Whole-life exposure to cadmium leads to elevated metal levels in the brain that further increases in high-fat diet fed mice.•Female animals…”
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Effects of cadmium and high-fat diet on essential metal concentration in the mouse testis by Zhou, Bin, Gentry, Adrienne, Xu, Qian, Young, Jamie L., Yan, Xiaofang, Pagidas, Kelly, Yang, Yu, Watson, Walter H., Kong, Maiying, Cai, Lu, Freedman, Jonathan H.

“…[Display omitted] •Whole life exposure to low doses of cadmium results in a significant accumulation of metals in the testis.•Co-exposure to cadmium with a…”
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Identification of innate immunity genes and pathways using a comparative genomics approach by Alper, Scott, Laws, Rebecca, Lackford, Brad, Boyd, Windy A, Dunlap, Paul, Freedman, Jonathan H, Schwartz, David A

“…To reveal regulators of innate immunity, we used RNAi assays to monitor the immune response when genes are inhibited in Caenorhabditis elegans and mouse…”
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The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks by Wang, Jiangbo, Lu, Jiuyi, Mook, Jr, Robert A, Zhang, Min, Zhao, Shengli, Barak, Larry S, Freedman, Jonathan H, Lyerly, H Kim, Chen, Wei

“…The spread of chemicals, including insecticides, into the environment often raises public health concerns, as exemplified by a recent epidemiologic study…”
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