Search Results - "Freed, M"

EARTHQUAKE TRIGGERING BY STATIC, DYNAMIC, AND POSTSEISMIC STRESS TRANSFER by Freed, Andrew M

“…▪ Abstract  Earthquake triggering is the process by which stress changes associated with an earthquake can induce or retard seismic activity in the surrounding…”
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Probing the lithospheric rheology across the eastern margin of the Tibetan Plateau by Huang, Mong-Han, Bürgmann, Roland, Freed, Andrew M.

“…The fundamental geological structure, geodynamics, and rheology of the Tibetan Plateau have been debated for decades. Two end-member models have been proposed:…”
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EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics by Freed, Daniel M., Bessman, Nicholas J., Kiyatkin, Anatoly, Salazar-Cavazos, Emanuel, Byrne, Patrick O., Moore, Jason O., Valley, Christopher C., Ferguson, Kathryn M., Leahy, Daniel J., Lidke, Diane S., Lemmon, Mark A.

“…Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct…”
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The Dark Side of Cell Signaling: Positive Roles for Negative Regulators by Lemmon, Mark A., Freed, Daniel M., Schlessinger, Joseph, Kiyatkin, Anatoly

“…Cell signaling is dominated by analyzing positive responses to stimuli. Signal activation is balanced by negative regulators that are generally considered to…”
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Afterslip (and only afterslip) following the 2004 Parkfield, California, earthquake by Freed, Andrew M.

“…An analysis of the first two years of postseismic surface deformations from GPS reveals that afterslip is the only mechanism significantly contributing to…”
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Formation of the Sputnik Planum basin and the thickness of Pluto's subsurface ocean by Johnson, Brandon C., Bowling, Timothy J., Trowbridge, Alexander J., Freed, Andrew M.

“…We simulate the formation of the large elliptical impact basin associated with Pluto's Sputnik Planum (SP; informal name). The location of SP suggests that it…”
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Emerging target discovery and drug repurposing opportunities in chordoma by Freed, Daniel M., Sommer, Josh, Punturi, Nindo

“…The development of effective and personalized treatment options for patients with rare cancers like chordoma is hampered by numerous challenges…”
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Triggering of New Madrid seismicity by late-Pleistocene erosion by Calais, E, Stein, S, Van Arsdale, R, Freed, A. M

“…The spatiotemporal behaviour of earthquakes within continental plate interiors is different from that at plate boundaries. At plate margins, tectonic motions…”
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Using short-term postseismic displacements to infer the ambient deformation conditions of the upper mantle by Freed, Andrew M., Hirth, Greg, Behn, Mark D.

“…To interpret short‐term postseismic surface displacements in the context of key ambient conditions (e.g., temperature, pressure, background strain rate, water…”
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Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts by Capasso, A, Lang, J, Pitts, T M, Jordan, K R, Lieu, C H, Davis, S L, Diamond, J R, Kopetz, S, Barbee, J, Peterson, J, Freed, B M, Yacob, B W, Bagby, S M, Messersmith, W A, Slansky, J E, Pelanda, R, Eckhardt, S G

“…The success of agents that reverse T-cell inhibitory signals, such as anti-PD-1/PD-L1 therapies, has reinvigorated cancer immunotherapy research. However,…”
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Putting together structures of epidermal growth factor receptors by Bessman, Nicholas J, Freed, Daniel M, Lemmon, Mark A

“…•Several studies suggest flexible linkage between extracellular and intracellular regions.•Others imply more rigid connections, required for allosteric…”
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Evidence of power-law flow in the Mojave desert mantle by Freed, Andrew M, Bürgmann, Roland

“…Studies of the Earth's response to large earthquakes can be viewed as large rock deformation experiments in which sudden stress changes induce viscous flow in…”
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Formation of the Orientale lunar multiring basin by Johnson, Brandon C., Blair, David M., Collins, Gareth S., Melosh, H. Jay, Freed, Andrew M., Taylor, G. Jeffrey, Head, James W., Wieczorek, Mark A., Andrews-Hanna, Jeffrey C., Nimmo, Francis, Keane, James T., Miljković, Katarina, Soderblom, Jason M., Zuber, Maria T.

“…Multiring basins, large impact craters characterized by multiple concentric topographic rings, dominate the stratigraphy, tectonics, and crustal structure of…”
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ANALYSIS OF FLOWS INSIDE QUIESCENT PROMINENCES AS CAPTURED BY HINODE/SOLAR OPTICAL TELESCOPE by Freed, M. S., McKenzie, D. E., Longcope, D. W., Wilburn, M.

“…ABSTRACT Developing an understanding of how magnetic fields can become entangled in a prominence is important for predicting a possible eruption. This work…”
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The Origin of Lunar Mascon Basins by Melosh, H. J., Freed, Andrew M., Johnson, Brandon C., Blair, David M., Andrews-Hanna, Jeffrey C., Neumann, Gregory A., Phillips, Roger J., Smith, David E., Solomon, Sean C., Wieczorek, Mark A., Zuber, Maria T.

“…High-resolution gravity data from the Gravity Recovery and Interior Laboratory spacecraft have clarified the origin of lunar mass concentrations (mascons)…”
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The structural stability of lunar lava tubes by Blair, David M., Chappaz, Loic, Sood, Rohan, Milbury, Colleen, Bobet, Antonio, Melosh, H. Jay, Howell, Kathleen C., Freed, Andrew M.

“…•We explore the stability of lava tubes on the Moon using finite element modeling.•Lava tube stability depends on roof thickness, width, and regional…”
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Mapping the landscape of genetic dependencies in chordoma by Sharifnia, Tanaz, Wawer, Mathias J., Goodale, Amy, Lee, Yenarae, Kazachkova, Mariya, Dempster, Joshua M., Muller, Sandrine, Levy, Joan, Freed, Daniel M., Sommer, Josh, Kalfon, Jérémie, Vazquez, Francisca, Hahn, William C., Root, David E., Clemons, Paul A., Schreiber, Stuart L.

“…Identifying the spectrum of genes required for cancer cell survival can reveal essential cancer circuitry and therapeutic targets, but such a map remains…”
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Vigorous convection as the explanation for Pluto’s polygonal terrain by Trowbridge, A. J., Melosh, H. J., Steckloff, J. K., Freed, A. M.

“…A parameterized convection model and observations of the puzzling polygons of the Sputnik Planum region of Pluto are used to compute the Rayleigh number of its…”
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Viscoelastic relaxation in a heterogeneous Earth following the 2004 Sumatra–Andaman earthquake by Wiseman, Kelly, Bürgmann, Roland, Freed, Andrew M., Banerjee, Paramesh

“…Consideration of the three-dimensional heterogeneity of mantle rheology allows models of viscoelastic relaxation following the 2004 Sumatra–Andaman earthquake…”
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Activity of pemetrexed in pre-clinical chordoma models and humans by Kesari, Santosh, Wang, Feng, Juarez, Tiffany, Ashili, Shashaanka, Patro, C. Pawan K., Carrillo, Jose, Nguyen, Minhdan, Truong, Judy, Levy, Joan, Sommer, Josh, Freed, Daniel M., Xiu, Joanne, Takasumi, Yuki, Bouffet, Eric, Gill, Jaya M.

“…Chordomas are rare slow growing tumors, arising from embryonic remnants of notochord with a close predilection for the axial skeleton. Recurrence is common and…”
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