Search Results - "Free, Meghan"

Allergic Sensitization through the Airway Primes Th17-dependent Neutrophilia and Airway Hyperresponsiveness by Wilson, Rhonda H, Whitehead, Gregory S, Nakano, Hideki, Free, Meghan E, Kolls, Jay K, Cook, Donald N

“…In humans, immune responses to inhaled aeroallergens develop in the lung and draining lymph nodes. Many animal models of asthma bypass this route and instead…”
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Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator by Zhu, Meng-Lei, Bakhru, Pearl, Conley, Bridget, Nelson, Jennifer S., Free, Meghan, Martin, Aaron, Starmer, Joshua, Wilson, Elizabeth M., Su, Maureen A.

“…Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune diseases. This protection may be due, in part, to higher androgen…”
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Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Have Defective Treg Cell Function Exacerbated by the Presence of a Suppression‐Resistant Effector Cell Population by Free, Meghan E., Bunch, Donna O'Dell, McGregor, Julie Anne, Jones, Britta E., Berg, Elisabeth A., Hogan, Susan L., Hu, Yichun, Preston, Gloria A., Jennette, J. Charles, Falk, Ronald J., Su, Maureen A.

“…Objective The development of pathogenic antineutrophil cytoplasmic antibodies (ANCAs) can result in systemic small vessel vasculitis. However, the breakdown in…”
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Mechanisms of vascular damage in ANCA vasculitis by Massicotte-Azarniouch, David, Herrera, Carolina A., Jennette, J. Charles, Falk, Ronald J., Free, Meghan E.

“…The discovery of anti-neutrophil cytoplasmic antibodies (ANCA) and their antigenic targets, myeloperoxidase (MPO) and proteinase 3 (PR3), has led to further…”
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Regulatory T cells effectively downregulate the autoimmune anti-MPO response and ameliorate anti-MPO induced glomerulonephritis in mice by Hu, Peiqi, Xiao, Hong, Elmore, Sandra, Agosto-Burgos, Christian, Hu, Yichun, Hogan, Susan L., Ciavatta, Dominic J., Falk, Ronald J., Jennette, J. Charles, Free, Meghan E.

“…Regulation of autoreactive cells is key for both prevention and amelioration of autoimmune disease. A better understanding of the key cell population(s)…”
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Immunological Interaction of HLA-DPB1 and Proteinase 3 in ANCA Vasculitis is Associated with Clinical Disease Activity by Chen, Dhruti P, McInnis, Elizabeth A, Wu, Eveline Y, Stember, Katherine G, Hogan, Susan L, Hu, Yichun, Henderson, Candace D, Blazek, Lauren N, Mallal, Simon, Karosiene, Edita, Peters, Bjoern, Sidney, John, James, Eddie A, Kwok, William W, Jennette, J Charles, Ciavatta, Dominic J, Falk, Ronald J, Free, Meghan E

“…PR3-ANCA vasculitis has a genetic association with HLA-DPB1. We explored immunologic and clinical features related to the interaction of HLA-DPB1*04:01 with a…”
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The Search for a Biomarker of Relapse in ANCA-Associated Vasculitis by Free, Meghan E, Falk, Ronald J

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Restricted myeloperoxidase epitopes drive the adaptive immune response in MPO-ANCA vasculitis by Free, Meghan E., Stember, Katherine G., Hess, Jacob J., McInnis, Elizabeth A., Lardinois, Olivier, Hogan, Susan L., Hu, Yichun, Mendoza, Carmen, Le, Andrew K., Guseman, Alex J., Pilkinton, Mark A., Bortone, Dante S., Cowens, Kristen, Sidney, John, Karosiene, Edita, Peters, Bjoern, James, Eddie, Kwok, William W., Vincent, Benjamin G., Mallal, Simon A., Jennette, J. Charles, Ciavatta, Dominic J., Falk, Ronald J.

“…Treatment of autoimmune diseases has relied on broad immunosuppression. Knowledge of specific interactions between human leukocyte antigen (HLA), the…”
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Dysregulation of autoantigen genes in ANCA-associated vasculitis involves alternative transcripts and new protein synthesis by McInnis, Elizabeth A, Badhwar, Anshul K, Muthigi, Akhil, Lardinois, Olivier M, Allred, S Colby, Yang, Jiajin, Free, Meghan E, Jennette, J Charles, Preston, Gloria A, Falk, Ronald J, Ciavatta, Dominic J

“…Proteinase 3 (PR3) and myeloperoxidase (MPO) are two major autoantigens in patients with vasculitis with ANCA. The genes encoding these autoantigens are…”
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Understanding Long-term Remission Off Therapy in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis by Hogan, Susan L, Nachman, Patrick H, Poulton, Caroline J, Hu, Yichun, Blazek, Lauren N, Free, Meghan E, Jennette, J Charles, Falk, Ronald J

“…In antineutrophil cytoplasmic antibody-associated (ANCA) vasculitis, relapse risk and long-term immunosuppressive therapy are problematic. Stopping…”
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Ozone activates pulmonary dendritic cells and promotes allergic sensitization through a Toll-like receptor 4–dependent mechanism by Hollingsworth, John W., MD, Free, Meghan E., BSc, Li, Zhuowei, MD, Andrews, Laura Novack, BSc, Nakano, Hideki, PhD, Cook, Donald N., PhD

“…[...]the effect of ozone on LN DCs has not been reported, and it is not known whether ozone promotes allergic sensitization through Toll-like receptor (TLR) 4,…”
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The frequency of Treg subsets distinguishes disease activity in ANCA vasculitis by Agosto‐Burgos, Christian, Wu, Eveline Y, Iannone, Marie A, Hu, Yichun, Hogan, Susan L, Henderson, Candace D, Kennedy, Kristin B, Blazek, Lauren, Herrera, Carolina A, Munson, Dominique, Falk, Ronald J, Ciavatta, Dominic J, Free, Meghan E

“…Objectives T regulatory cells (Tregs) are a heterogeneous group of immunoregulatory cells that dampen self‐harming immune responses and prevent the development…”
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IL-17A in experimental glomerulonephritis: where does it come from? by Free, Meghan E, Falk, Ronald J

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L26. How antigens influence the disease: An immunologist point of view by Free, Meghan E., Ciavatta, Dominic J., Falk, Ronald J.

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In Vitro Expansion of Regulatory T Cells Restores Functional Capacity in ANCA Vasculitis: TH-PO552 by Free, Meghan E., Elmore, Sandra H., Ciavatta, Dominic J., Falk, Ronald

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Transplanted Immune Competent Bone Marrow or Spleen Stem Cells Prevent Myeloperoxidase (MPO)-ANCA Glomerulonephritis in Immune-Deficient Mice: FR-PO683 by Hu, Peiqi, Xiao, Hong, Hu, Yanglin, Gou, Shen-Ju, Free, Meghan E., Falk, Ronald, Jennette, J. Charles

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High-resolution epitope mapping of commercial antibodies to ANCA antigens by yeast surface display by Poulton, John S., Lamba, Sajan, Free, Meghan, Xi, Gang, McInnis, Elizabeth, Williams, Gabrielle, Kudlacek, Stephan T., Thieker, David, Kuhlman, Brian, Falk, Ronald

“…Epitope mapping provides critical insight into antibody-antigen interactions. Epitope mapping of autoantibodies from patients with autoimmune diseases can help…”
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Reply by Free, Meghan E, Su, Maureen A

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Association of HLA-DPB104:01 and Maintenance of Remission in ANCA-Associated Vasculitis: FR-OR36 by Chen, Dhruti P., McInnis, Elizabeth A., Wu, Eve, Stember, Katherine G., Hogan, Susan L., Hu, Yichun, Henderson, Candace D., Blazek, Lauren N., Mallal, Simon, James, Eddie A., Jennette, J. Charles, Ciavatta, Dominic J., Falk, Ronald J., Free, Meghan E.

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Inhibitory Anti-Peroxidasin Antibodies in Pulmonary-Renal Syndromes by McCall, A Scott, Bhave, Gautam, Pedchenko, Vadim, Hess, Jacob, Free, Meghan, Little, Dustin J, Baker, Thomas P, Pendergraft, 3rd, William F, Falk, Ronald J, Olson, Stephen W, Hudson, Billy G

“…Goodpasture syndrome (GP) is a pulmonary-renal syndrome characterized by autoantibodies directed against the NC1 domains of collagen IV in the glomerular and…”
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