Search Results - "Fredriksson, Lisa"

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability by Hendriks, Delilah F. G., Fredriksson Puigvert, Lisa, Messner, Simon, Mortiz, Wolfgang, Ingelman-Sundberg, Magnus

“…Drug-induced cholestasis (DIC) is poorly understood and its preclinical prediction is mainly limited to assessing the compound’s potential to inhibit the bile…”
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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease by Bell, Catherine C., Hendriks, Delilah F. G., Moro, Sabrina M. L., Ellis, Ewa, Walsh, Joanne, Renblom, Anna, Fredriksson Puigvert, Lisa, Dankers, Anita C. A., Jacobs, Frank, Snoeys, Jan, Sison-Young, Rowena L., Jenkins, Rosalind E., Nordling, Åsa, Mkrtchian, Souren, Park, B. Kevin, Kitteringham, Neil R., Goldring, Christopher E. P., Lauschke, Volker M., Ingelman-Sundberg, Magnus

“…Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to study using current in vitro models such as primary human…”
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Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening by Di, Zi, Herpers, Bram, Fredriksson, Lisa, Yan, Kuan, van de Water, Bob, Verbeek, Fons J, Meerman, John H N

“…Nuclear entry and exit of the NF-κB family of dimeric transcription factors plays an essential role in regulating cellular responses to inflammatory stress…”
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Cross-talk between integrins and oncogenes modulates chemosensitivity by Puigvert, Jordi Carreras, Huveneers, Stephan, Fredriksson, Lisa, op het Veld, Marieke, van de Water, Bob, Danen, Erik H J

“…Chemotherapy often relies on cancer cell death resulting from DNA damage. The p53 tumor suppressor pathway that is an important player in DNA damage response…”
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Placental pathology in a large (Swedish) cohort of SARS-CoV-2 infected mothers by Fredriksson, Lisa, Tidholm Qvist, Evelina, Sirotkina, Meeli, Pettersson, Karin, Papadogiannakis, Nikos

“…SARS-CoV-2 placentitis is associated with placental destruction and insufficiency and can affect perinatal outcome. The aim of the current study was to…”
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TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells by Benedetti, Giulia, Fredriksson, Lisa, Herpers, Bram, Meerman, John, van de Water, Bob, de Graauw, Marjo

“…Cisplatin-induced nephrotoxicity is an important limiting factor for cisplatin use. Tumor necrosis factor-α (TNF-α) is known to contribute to cisplatin-induced…”
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Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity by Herpers, Bram, Wink, Steven, Fredriksson, Lisa, Di, Zi, Hendriks, Giel, Vrieling, Harry, de Bont, Hans, van de Water, Bob

“…Drug-induced liver injury (DILI) is an important problem both in the clinic and in the development of new safer medicines. Two pivotal adaptation and survival…”
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Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity by Fredriksson, Lisa, Wink, Steven, Herpers, Bram, Benedetti, Giulia, Hadi, Mackenzie, de Bont, Hans, Groothuis, Geny, Luijten, Mirjam, Danen, Erik, de Graauw, Marjo, Meerman, John, van de Water, Bob

“…Drug-induced liver injury (DILI) is an important clinical problem. Here, we used a genomics approach to in detail investigate the hypothesis that critical…”
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Early suppression policies protected pregnant women from COVID‐19 in 2020: A population‐based surveillance from the Nordic countries by Varpula, Reetta, Äyräs, Outi, Aabakke, Anna J. M., Klungsøyr, Kari, Svanvik, Teresia, Kanerva, Julia, Jonasdottir, Eva, Mentzoni, Camilla Tjønneland, Thurn, Lars, Jones, Elin, Fredriksson, Lisa, Pettersson, Karin, Nyfløt, Lill Trine, Vangen, Siri, Røe, Kjerstine, Júlíusson, Pétur B., Källén, Karin, Gissler, Mika, Pyykönen, Aura, Jakobsson, Maija, Krebs, Lone, Engjom, Hilde Marie

“…Introduction The Coronavirus 2019 Disease (COVID‐19) pandemic reached the Nordic countries in March 2020. Public health interventions to limit viral…”
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Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis by Fredriksson, Lisa, Herpers, Bram, Benedetti, Giulia, Matadin, Quraisha, Puigvert, Jordi C., de Bont, Hans, Dragovic, Sanja, Vermeulen, Nico P.E., Commandeur, Jan N.M., Danen, Erik, de Graauw, Marjo, van de Water, Bob

“…Drug‐induced liver injury (DILI) is an important clinical problem. It involves crosstalk between drug toxicity and the immune system, but the exact mechanism…”
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Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-[kappa]B activation and sensitizes toward TNF[alpha]-induced cytotoxicity by Herpers, Bram, Wink, Steven, Fredriksson, Lisa, Di, Zi, Hendriks, Giel, Vrieling, Harry, de Bont, Hans, van de Water, Bob

“…Drug-induced liver injury (DILI) is an important problem both in the clinic and in the development of new safer medicines. Two pivotal adaptation and survival…”
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The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch by Benedetti, Giulia, Fokkelman, Michiel, Yan, Kuan, Fredriksson, Lisa, Herpers, Bram, Meerman, John, van de Water, Bob, de Graauw, Marjo

“…Cis-diamminedichloroplatinum(II) (cisplatin)-induced renal proximal tubular apoptosis is known to be preceded by actin cytoskeleton reorganization, in…”
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Characterization of heterotypic 3D human liver microtissues for drug-induced hepatotoxicity testing by Gunness, Patrina, Messner, Simon, Fredriksson, Lisa, Kelm, Jens, Moritz, Wolfgang, Ingelman-Sundberg, Magnus

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Automated Analysis of NF-[kappa]B Nuclear Translocation Kinetics in High-Throughput Screening by Di, Zi, Herpers, Bram, Fredriksson, Lisa, Yan, Kuan, van de Water, Bob, Verbeek, Fons J, Meerman, John H. N

“…Nuclear entry and exit of the NF-[kappa]B family of dimeric transcription factors plays an essential role in regulating cellular responses to inflammatory…”
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Three-dimensional (3D) human hepatocyte spheroids as model for prediction of DILI: Effect of viral infection and TNFα on function and drug toxicity by Moro, Sabrina, Persson, Anna, Bell, Catherine, Puigvert, Lisa Fredriksson, Hendriks, Delilah, Sim, Sarah, Ingelman-Sundberg, Magnus

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Diclofenac inhibits tumor necrosis factor-[alpha]-induced nuclear factor-[kappa]B activation causing synergistic hepatocyte apoptosis by Fredriksson, Lisa, Herpers, Bram, Benedetti, Giulia, Matadin, Quraisha, Puigvert, Jordi C, de Bont, Hans, Dragovic, Sanja, Vermeulen, Nico PE, Commandeur, Jan NM, Danen, Erik, de Graauw, Marjo, van de Water, Bob

“…Drug-induced liver injury (DILI) is an important clinical problem. It involves crosstalk between drug toxicity and the immune system, but the exact mechanism…”
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