Search Results - "Frederix, Liesbeth"

Fumagillin Reduces Adipose Tissue Formation in Murine Models of Nutritionally Induced Obesity by Lijnen, Henri R., Frederix, Liesbeth, Hoef, Berthe

“…The effect of fumagillin (a methionine aminopeptidase‐type 2 (Met‐AP2) inhibitor, with antiangiogenic properties) was investigated in murine models of…”
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Advanced-age C57BL/6JRj mice do not develop obesity upon western-type diet exposure by Vercalsteren, Ellen, Vranckx, Christine, Frederix, Liesbeth, Lox, Marleen, Lijnen, H. Roger, Scroyen, Ilse, Hemmeryckx, Bianca

“…Obesity has become a global health-threat for every age group. It is well known that young mice (10-12 weeks of age) fed a western-type diet (WD) become obese…”
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Tiplaxtinin impairs nutritionally induced obesity in mice by Lijnen, H Roger, Alessi, Marie-Christine, Frederix, Liesbeth, Collen, Désiré, Juhan-Vague, Irène

“…To investigate the effect of tiplaxtinin, designed as a synthetic inhibitor of plasminogen activator inhibitor-1 (PAI-1), on obesity, male C57Bl/6 mice (13-14…”
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Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis by Hemmeryckx, Bianca, Frederix, Liesbeth, Lijnen, H. Roger

“…Mice deficient in the circadian clock gene BMAL1 (Brain and Muscle ARNT-like protein-1) exhibit a hypercoagulable state and an enhanced arterial and venous…”
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Abstract 12769: Neutrophil Peptidylarginine Deiminase 4 is Essential for Detrimental Age-Related Cardiac Remodeling in Mice by Van Bruggen, Stijn, Martinod, Kimberly, Witsch, Thilo, Frederix, Liesbeth, Carai, Paolo, Van wauwe, Jore

“…During a period of chronic inflammation, such as in aging, neutrophils have a decreased threshold for activation. Neutrophils express peptidylarginine…”
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Neutrophil peptidylarginine deiminase 4 is essential for detrimental age-related cardiac remodelling and dysfunction in mice by Van Bruggen, Stijn, Kraisin, Sirima, Van Wauwe, Jore, Bomhals, Katrien, Stroobants, Mathias, Carai, Paolo, Frederix, Liesbeth, Van De Bruaene, Alexander, Witsch, Thilo, Martinod, Kimberly

“…Mice fully deficient in peptidylarginine deiminase 4 (PAD4) enzyme have preserved cardiac function and reduced collagen deposition during ageing. The cellular…”
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Neutrophil peptidylarginine deiminase 4 plays a systemic role in obesity-induced chronic inflammation in mice by Van Bruggen, Stijn, Sheehy, Casey E., Kraisin, Sirima, Frederix, Liesbeth, Wagner, Denisa D., Martinod, Kimberly

“…Obesity is an increasing problem in our current society and is expected to keep rising in incidence. With its multiorigin, complex pathophysiology, it is…”
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Dietary carbohydrates as a means to prevent obesity and adipose tissue inflammation by Vercalsteren, Ellen, Vranckx, Christine, Frederix, Liesbeth, Gooijen, Max, Scroyen, Ilse

“…When obesity arises, adipose tissue (AT) expands and shifts to an influx of pro-inflammatory cells, leading to a state of chronic AT-inflammation.Furthermore,…”
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Neutrophils Protect Against Staphylococcus aureus Endocarditis Progression Independent of Extracellular Trap Release by Meyers, Severien, Lox, Marleen, Kraisin, Sirima, Liesenborghs, Laurens, Martens, Caroline P., Frederix, Liesbeth, Van Bruggen, Stijn, Crescente, Marilena, Missiakas, Dominique, Baatsen, Pieter, Vanassche, Thomas, Verhamme, Peter, Martinod, Kimberly

“…Infective endocarditis (IE) is characterized by an infected thrombus at the heart valves. How bacteria bypass the immune system and cause these thrombi remains…”
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Neutrophils Protect Against Staphylococcus aureus Endocarditis Progression Independent of Extracellular Trap Release by Meyers, Severien, Lox, Marleen, Kraisin, Sirima, Liesenborghs, Laurens, Martens, Caroline P., Frederix, Liesbeth, Van Bruggen, Stijn, Crescente, Marilena, Missiakas, Dominique, Baatsen, Pieter, Vanassche, Thomas, Verhamme, Peter, Martinod, Kimberly

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Evaluation of cardiac arrhythmic risks using a rabbit model of left ventricular systolic dysfunction by Hemmeryckx, Bianca, Feng, Yuanbo, Frederix, Liesbeth, Lox, Marleen, Trenson, Sander, Vreeken, Rob, Lu, Hua Rong, Gallacher, David, Ni, Yicheng, Lijnen, H. Roger

“…Patients with heart disease have a higher risk to develop cardiac arrhythmias, either spontaneously or drug-induced. In this study, we have used a rabbit model…”
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Axl Deficiency Does Not Affect Adipogenesis or Adipose Tissue Development by Scroyen, Ilse, Frederix, Liesbeth, Lijnen, H Roger

“…To evaluate a potential role of Axl, the high‐affinity receptor of growth arrest‐specific protein 6 (GAS6) in adiposity, murine embryonic fibroblasts (MEF)…”
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Role of Thrombospondin-2 in Murine Adipose Tissue Angiogenesis and Development by Hul, Matthias, Frederix, Liesbeth, Lijnen, H. Roger

“…Expression of thrombospondin‐2 (TSP‐2), a matricellular protein with anti‐angiogenic properties, is modulated in developing adipose tissue. To investigate a…”
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Monitoring reperfused myocardial infarction with delayed left ventricular systolic dysfunction in rabbits by longitudinal imaging by Feng, Yuanbo, Hemmeryckx, Bianca, Frederix, Liesbeth, Lox, Marleen, Wu, Jun, Heggermont, Ward, Lu, Hua Rong, Gallacher, David, Oyen, Raymond, Lijnen, H Roger, Ni, Yicheng

“…An experimental imaging platform for longitudinal monitoring and evaluation of cardiac morphology-function changes has been long desired. We sought to…”
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Matrix Metalloproteinase Inhibition Impairs Adipose Tissue Development in Mice by Lijnen, H R, Maquoi, E, Hansen, L B, Van Hoef, B, Frederix, L, Collen, D

“…ABSTRACT—The effect of galardin, a broad-spectrum matrix metalloproteinase (MMP) inhibitor, was studied in mice kept on a high fat diet (HFD). Five-week-old…”
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