Search Results - "Frederick T.J. Lin"
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Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis
Published in PLoS medicine (23-06-2020)“…Polycystic ovary syndrome (PCOS) is a common, complex genetic disorder affecting up to 15% of reproductive-age women worldwide, depending on the diagnostic…”
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Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes
Published in Human molecular genetics (29-09-2022)“…Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is…”
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Esophageal Hypervigilance and Visceral Anxiety Are Contributors to Symptom Severity Among Patients Evaluated With High-Resolution Esophageal Manometry
Published in The American journal of gastroenterology (01-03-2020)“…Symptoms are inconsistently associated with esophageal motor findings on high-resolution manometry (HRM). We aimed to evaluate predictors of dysphagia…”
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The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype
Published in Genetic epidemiology (01-02-2019)“…The Electronic Medical Records and Genomics (eMERGE) network is a network of medical centers with electronic medical records linked to existing biorepository…”
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Multi-ancestry genome- and phenome-wide association studies of diverticular disease in electronic health records with natural language processing enriched phenotyping algorithm
Published in PloS one (17-05-2023)“…Diverticular disease (DD) is one of the most prevalent conditions encountered by gastroenterologists, affecting ~50% of Americans before the age of 60. Our aim…”
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IκB Kinase-β Regulates Neutrophil Recruitment Through Activation of STAT3 Signaling in the EsophagusSummary
Published in Cellular and molecular gastroenterology and hepatology (01-01-2021)“…Background & Aims: The epithelial barrier is the host’s first line of defense against damage to the underlying tissue. Upon injury, the epithelium plays a…”
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Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
Published in BMC medical genomics (04-06-2022)“…Head circumference is associated with intelligence and tracks from childhood into adulthood. We performed a genome-wide association study meta-analysis and…”
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IκB Kinase-β Regulates Neutrophil Recruitment Through Activation of STAT3 Signaling in the Esophagus
Published in Cellular and molecular gastroenterology and hepatology (01-01-2021)“…The epithelial barrier is the host’s first line of defense against damage to the underlying tissue. Upon injury, the epithelium plays a critical role in…”
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Journal Article