Search Results - "Frederick, Michael O."

Zur Struktur des Maitotoxins by Nicolaou, K. C., Frederick, Michael O.

“…Richtig rum? Betrachtungen zur Biosynthese ließen jüngst Zweifel bezüglich der ursprünglich vorgeschlagenen Struktur des Maitotoxins aufkommen, und speziell…”
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Die Entdeckung und Synthese von marinen Polyethern by Nicolaou, K. C., Frederick, Michael O., Aversa, Robert J.

“…Die beispiellose Struktur des marinen Naturstoffs Brevetoxin B wurde 1981 von den Arbeitsgruppen um Nakanishi und Clardy aufgeklärt. Das leiterförmige…”
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Titelbild: Die Entdeckung und Synthese von marinen Polyethern (Angew. Chem. 38/2008) by Nicolaou, K. C., Frederick, Michael O., Aversa, Robert J.

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Total Synthesis and Confirmation of the Revised Structures of Azaspiracid‐2 and Azaspiracid‐3 by Nicolaou, K. C., Frederick, Michael O., Petrovic, Goran, Cole, Kevin P., Loizidou, Eriketi Z.

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Titelbild: Structural Revision and Total Synthesis of Azaspiracid‐1, Part 1: Intelligence Gathering and Tentative Proposal (Angew. Chem. 33/2004) by Nicolaou, K. C., Vyskocil, Stepan, Koftis, Theocharis V., Yamada, Yoichi M. A., Ling, Taotao, Chen, David Y.‐K., Tang, Wenjun, Petrovic, Goran, Frederick, Michael O., Li, Yiwei, Satake, Masayuki

“…Das Muscheltoxin Azaspiracid‐1 aus Mytilus edulis hat für erhebliche Verwirrung gesorgt, denn ursprünglich war eine falsche Struktur für die Verbindung…”
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Continuing Saga of the Marine Polyether Biotoxins by Nicolaou, K.C, Frederick, Michael O, Aversa, Robert J

“…The unprecedented structure of the marine natural product brevetoxin B was elucidated by the research group of Nakanishi and Clardy in 1981. The ladderlike…”
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Accelerated and Scalable C(sp3)–H Amination via Decatungstate Photocatalysis Using a Flow Photoreactor Equipped with High-Intensity LEDs by Wan, Ting, Wen, Zhenghui, Laudadio, Gabriele, Capaldo, Luca, Lammers, Rob, Rincón, Juan A, García-Losada, Pablo, Mateos, Carlos, Frederick, Michael O, Broersma, Rémy, Noël, Timothy

“…Carbon–nitrogen bonds are ubiquitous in biologically active compounds, prompting synthetic chemists to design various methodologies for their preparation…”
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Development of a Leuckart–Wallach Reaction in Flow for the Synthesis of Abemaciclib by Frederick, Michael O, Pietz, Mark A, Kjell, Douglas P, Richey, Rachel N, Tharp, Gregg A, Touge, Taichiro, Yokoyama, Naota, Kida, Michio, Matsuo, Toshiyasu

“…The development of a route for a key building block in the synthesis of abemaciclib is described. The route proceeds through a Leuckart–Wallach reductive…”
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On the Structure of Maitotoxin by Nicolaou, K. C., Frederick, Michael O.

“…The right way round? Biosynthetic considerations have put the reported structure of maitotoxin in doubt, in particular the stereochemistry of its J/K ring…”
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Chemical Synthesis of the GHIJK Ring System and Further Experimental Support for the Originally Assigned Structure of Maitotoxin by Nicolaou, K.C, Cole, Kevin P, Frederick, Michael O, Aversa, Robert J, Denton, Ross M

“…Accepting the proposal: The originally proposed structure of maitotoxin has recently come under scrutiny based on biosynthetic and computational…”
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A Copper-Catalyzed C−N Bond Formation Involving sp-Hybridized Carbons. A Direct Entry to Chiral Ynamides via N-Alkynylation of Amides by Frederick, Michael O, Mulder, Jason A, Tracey, Michael R, Hsung, Richard P, Huang, Jian, Kurtz, Kimberly C. M, Shen, Lichun, Douglas, Christopher J

“…A copper-catalyzed new C−N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This…”
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Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin by Nicolaou, K. C, Frederick, Michael O, Burtoloso, Antonio C. B, Denton, Ross M, Rivas, Fatima, Cole, Kevin P, Aversa, Robert J, Gibe, Romelo, Umezawa, Taiki, Suzuki, Takahiro

“…As the largest secondary metabolite to be discovered as of yet, the polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic…”
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Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes by Song, Lu, Fu, Niankai, Ernst, Brian G., Lee, Wai Hang, Frederick, Michael O., DiStasio, Robert A., Lin, Song

“…Chiral nitriles and their derivatives are prevalent in pharmaceuticals and bioactive compounds. Enantioselective alkene hydrocyanation represents a convenient…”
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Total Synthesis and Confirmation of the Revised Structures of Azaspiracid-2 and Azaspiracid-3 by Nicolaou, K. C., Frederick, Michael O., Petrovic, Goran, Cole, Kevin P., Loizidou, Eriketi Z.

“…The 39 steps: The recently proposed revised structures of azaspiracid‐2 and ‐3 (see picture), the two most potent members of the azaspiracid family, have been…”
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Structural Revision and Total Synthesis of Azaspiracid-1, Part 2: Definition of the ABCD Domain and Total Synthesis by Nicolaou, K. C., Koftis, Theocharis V., Vyskocil, Stepan, Petrovic, Goran, Ling, Taotao, Yamada, Yoichi M. A., Tang, Wenjun, Frederick, Michael O.

“…The chase for the structure of azaspiracid‐1 has ended with a revised structure (see picture). The total synthesis of this challenging target has closed…”
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Total Synthesis and Structural Elucidation of Azaspiracid-1. Final Assignment and Total Synthesis of the Correct Structure of Azaspiracid-1 by Nicolaou, K. C, Koftis, Theocharis V, Vyskocil, Stepan, Petrovic, Goran, Tang, Wenjun, Frederick, Michael O, Chen, David Y.-K, Li, Yiwei, Ling, Taotao, Yamada, Yoichi M. A

“…The molecular structure of azaspiracid-1, a neurotoxin isolated from mussels, has been elucidated by total synthesis which also enriched its supplies. The…”
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Effects of Azaspiracid-1, A Potent Cytotoxic Agent, on Primary Neuronal Cultures. A Structure−Activity Relationship Study by Vale, Carmen, Nicolaou, K. C., Frederick, Michael O., Gómez-Limia, Belén, Alfonso, Amparo, Vieytes, Mercedes R., Botana, Luis M.

“…Azaspiracids (AZAs) are marine phycotoxins with an unknown mechanism of action, implicated in human intoxications. We investigated the effect of azaspiracid-1…”
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Decatungstate‐Mediated C(sp3)–H Heteroarylation via Radical‐Polar Crossover in Batch and Flow by Wan, Ting, Capaldo, Luca, Laudadio, Gabriele, Nyuchev, Alexander V., Rincón, Juan A., García‐Losada, Pablo, Mateos, Carlos, Frederick, Michael O., Nuño, Manuel, Noël, Timothy

“…Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp3)–H functionalization of organic molecules. Herein, we report on…”
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Total Synthesis and Structural Elucidation of Azaspiracid-1. Construction of Key Building Blocks for Originally Proposed Structure by Nicolaou, K. C, Pihko, Petri M, Bernal, Federico, Frederick, Michael O, Qian, Wenyuan, Uesaka, Noriaki, Diedrichs, Nicole, Hinrichs, Jürgen, Koftis, Theocharis V, Loizidou, Eriketi, Petrovic, Goran, Rodriquez, Manuela, Sarlah, David, Zou, Ning

“…Syntheses of the three key building blocks (65, 98, and 100) required for the total synthesis of the proposed structure of azaspiracid-1 (1a) are described…”
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Structural Revision and Total Synthesis of Azaspiracid-1, Part 1: Intelligence Gathering and Tentative Proposal by Nicolaou, K. C., Vyskocil, Stepan, Koftis, Theocharis V., Yamada, Yoichi M. A., Ling, Taotao, Chen, David Y.-K., Tang, Wenjun, Petrovic, Goran, Frederick, Michael O., Li, Yiwei, Satake, Masayuki

“…Phantom molecules from Nature: Degradation studies of azaspiracid‐1 (see originally proposed, incorrect structure), the notorious marine neurotoxin isolated…”
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