Search Results - "Frederick, Malinda"

Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion by Raghu, Harini, Cruz, Carolina, Rewerts, Cheryl L., Frederick, Malinda D., Thornton, Sherry, Mullins, Eric S., Schoenecker, Jonathan G., Degen, Jay L., Flick, Matthew J.

“…Rheumatoid arthritis is a chronic inflammatory disease characterized by synovial hyperplasia, inflammatory cell infiltration, irreversible cartilage and bone…”
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Plasminogen Is a Joint‐Specific Positive or Negative Determinant of Arthritis Pathogenesis in Mice by Raghu, Harini, Jone, Alice, Cruz, Carolina, Rewerts, Cheryl L., Frederick, Malinda D., Thornton, Sherry, Degen, Jay L., Flick, Matthew J.

“…Objective A fundamental metric in the diagnosis of arthropathies is the pattern of joint involvement, including differences in proximal versus distal joints…”
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Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells by Thornton, Sherry, Raghu, Harini, Cruz, Carolina, Frederick, Malinda D., Palumbo, Joseph S., Mullins, Eric S., Almholt, Kasper, Usher, Pernille A., Flick, Matthew J.

“…The plasminogen activation (PA) system has been implicated in driving inflammatory arthritis, but the precise contribution of PA system components to arthritis…”
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Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity by Qi, Xiaoyang, Flick, Matthew J, Frederick, Malinda, Chu, Zhengtao, Mason, Rachel, DeLay, Monica, Thornton, Sherry

“…Rheumatoid arthritis is a chronic inflammatory disease affecting approximately 1% of the population and is characterized by cartilage and bone destruction…”
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Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen by Adams, Gregory N, Rosenfeldt, Leah, Frederick, Malinda, Miller, Whitney, Waltz, Dusty, Kombrinck, Keith, McElhinney, Kathryn E, Flick, Matthew J, Monia, Brett P, Revenko, Alexey S, Palumbo, Joseph S

“…Thrombin-mediated proteolysis is a major determinant of metastasis, but is not universally important for primary tumor growth. Here, we report that colorectal…”
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Protease Activated Receptor-1 (PAR-1) Impedes Tumor Progression by Adams, Gregory N., Weston, Haley, Rosenfeldt, Leah, Frederick, Malinda, Palumbo, Joseph S.

“…Activation of cell signaling by thrombin through Protease Activated Receptor-1 (PAR-1) represents one important interface between blood coagulation and cell…”
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Mechanisms Linking Fibrin(ogen) Structure/Function to Tumor Metastasis by Remiker, Allison S., Rosenfeldt, Leah A., Adams, Greg N., Flick, Matthew J., Frederick, Malinda D., Palumbo, Joseph S.

“…Previous studies established that the platelet/fibrin(ogen) axis promotes metastatic potential by impeding the clearance of newly formed micrometastases by…”
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Protease‐activated receptor‐1 impedes prostate and intestinal tumor progression in mice by Adams, G. N., Sharma, B. K., Rosenfeldt, L., Frederick, M., Flick, M. J., Witte, D. P., Mosnier, L. O., Harmel‐Laws, E., Steinbrecher, K. A., Palumbo, J. S.

“…Essentials Protease activated receptor‐1 (PAR‐1) has been proposed to drive cancer progression. Surprisingly, PAR‐1 deletion accelerated tumor progression in…”
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Thrombin and Factor XII Drive Prostate Tumor Growth In Vivo by Adams, Gregory, Rosenfeldt, Leah, Frederick, Malinda, Kombrinck, Keith, Monia, Brett P., Revenko, Alexey, Palumbo, Joseph S.

“…Several hemostatic factors are known to strongly influence the metastatic process by promoting the survival of early metastases. Despite this consistent…”
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Thrombin Drives Colorectal Cancer Pathogenesis at the Level of Primary Tumor Growth, Tumor Invasion and Metastasis by Adams, Gregory N, Waltz, Dusty, Rosenfeldt, Leah, Frederick, Malinda, Miller, Whitney, Revenko, Alexey S, Monia, Brett P., Palumbo, Joseph S.

“…Cell-associated and circulating hemostatic factors have been identified as powerful determinants of tumor cell metastatis, primarily by supporting the early…”
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Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis by Thornton, Sherry, Raghu, Harini, Jone, Alice, Cruz, Carolina, Rewerts, Cheryl L., Frederick, Malinda D., Degen, Jay L., Flick, Matthew J.

“…Rheumatoid arthritis (RA) is a common and debilitating autoimmune disease characterized by chronic inflammation, synovial hyperplasia, edema, cartilage and…”
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Plasminogen Mediates Both Positive and Negative Effects on Disease Severity in a Mouse Model of TNFα-Driven Arthritis by Raghu, Harini, Frederick, Malinda D., Jone, Alice, Talmage, Kathryn E., Kombrinck, Keith W., Flick, Matthew J.

“…Abstract 854 Rheumatoid arthritis is a chronic inflammatory disease of joint tissue wherein dysregulated, robust hemostatic system activity is a consistent…”
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The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A by Flick, Matthew J., Chauhan, Anil K., Frederick, Malinda, Talmage, Kathryn E., Kombrinck, Keith W., Miller, Whitney, Mullins, Eric S., Palumbo, Joseph S., Zheng, Xunzhen, Esmon, Naomi L., Esmon, Charles T., Thornton, Sherry, Becker, Ann, Pelc, Leslie A., Di Cera, Enrico, Wagner, Denisa D., Degen, Jay L.

“…Thrombin is a positive mediator of thrombus formation through the proteolytic activation of protease-activated receptors (PARs), fibrinogen, factor XI (fXI),…”
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In vivo optical imaging of brain tumors and arthritis using fluorescent SapC-DOPS nanovesicles by Chu, Zhengtao, LaSance, Kathleen, Blanco, Victor, Kwon, Chang-Hyuk, Kaur, Balveen, Frederick, Malinda, Thornton, Sherry, Lemen, Lisa, Qi, Xiaoyang

“…We describe a multi-angle rotational optical imaging (MAROI) system for in vivo monitoring of physiopathological processes labeled with a fluorescent marker…”
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In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles by Chu, Zhengtao, LaSance, Kathleen, Blanco, Victor, Kwon, Chang-Hyuk, Kaur, Balveen, Frederick, Malinda, Thornton, Sherry, Lemen, Lisa, Qi, Xiaoyang

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