Search Results - "Frederick, Barbara"

Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models by Frederick, Barbara A., Gupta, Rohit, Atilano-Roque, Amandla, Su, Tin Tin, Raben, David

“…Head and neck squamous cell carcinoma (HNSCC) is a challenging cancer with little change in five-year overall survival rate of 50–60% over the last two…”
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Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non–small cell lung carcinoma by Frederick, Barbara A, Helfrich, Barbara A, Coldren, Christopher D, Zheng, Di, Chan, Dan, Bunn, Jr, Paul A, Raben, David

“…The modest response of patients with head and neck squamous cell carcinoma (HNSCC) and non–small cell lung carcinoma (NSCLC) to epithelial growth factor…”
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Fibroblast Growth Factor Receptors Are Components of Autocrine Signaling Networks in Head and Neck Squamous Cell Carcinoma Cells by MARSHALL, Marianne E, HINZ, Trista K, KONO, Scott A, SINGLETON, Katherine R, BICHON, Brady, WARE, Kathryn E, MAREK, Lindsay, FREDERICK, Barbara A, RABEN, David, HEASLEY, Lynn E

“…We previously reported that a fibroblast growth factor (FGF) receptor (FGFR) signaling pathway drives growth of lung cancer cell lines of squamous and large…”
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Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules by Ramteke, Anand, Ting, Harold, Agarwal, Chapla, Mateen, Samiha, Somasagara, Ranganathan, Hussain, Anowar, Graner, Michael, Frederick, Barbara, Agarwal, Rajesh, Deep, Gagan

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Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers by Gan, Gregory N, Eagles, Justin, Keysar, Stephen B, Wang, Guoliang, Glogowska, Magdalena J, Altunbas, Cem, Anderson, Ryan T, Le, Phuong N, Morton, J Jason, Frederick, Barbara, Raben, David, Wang, Xiao-Jing, Jimeno, Antonio

“…Local control and overall survival in patients with advanced head and neck squamous cell cancer (HNSCC) remains dismal. Signaling through the Hedgehog (Hh)…”
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The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas by Anderson, Ryan T, Keysar, Stephen B, Bowles, Daniel W, Glogowska, Magdalena J, Astling, David P, Morton, J Jason, Le, Phuong, Umpierrez, Adrian, Eagles-Soukup, Justin, Gan, Gregory N, Vogler, Brian W, Sehrt, Daniel, Takimoto, Sarah M, Aisner, Dara L, Wilhelm, Francois, Frederick, Barbara A, Varella-Garcia, Marileila, Tan, Aik-Choon, Jimeno, Antonio

“…The dual pathway inhibitor rigosertib inhibits phosphoinositide 3-kinase (PI3K) pathway activation as well as polo-like kinase 1 (PLK1) activity across a broad…”
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The antioxidant, MnTE-2-PyP, prevents side-effects incurred by prostate cancer irradiation by Oberley-Deegan, Rebecca E, Steffan, Joshua J, Rove, Kyle O, Pate, Kathryn M, Weaver, Michael W, Spasojevic, Ivan, Frederick, Barbara, Raben, David, Meacham, Randall B, Crapo, James D, Koul, Hari K

“…Prostate cancer is the most commonly diagnosed cancer, with an estimated 240,000 new cases reported annually in the United States. Due to early detection and…”
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Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells by Edwards, Anthony, Gladstone, Mara, Yoon, Petros, Raben, David, Frederick, Barbara, Su, Tin Tin

“…Combination therapy, in which two or more agents are applied, is more effective than single therapies for combating cancer. For this reason, combinations of…”
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A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer by Gladstone, Mara, Frederick, Barbara, Zheng, Di, Edwards, Anthony, Yoon, Petros, Stickel, Stefanie, DeLaney, Tessie, Chan, Daniel C, Raben, David, Su, Tin Tin

“…We described previously a screening protocol in Drosophila melanogaster that allows us to identify small molecules that increase the killing effect of ionizing…”
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Abstract 3055: Clonogenic high-throughput assay for screening radiation modulators by Frederick, Barbara, Gomes, Nathan, Su, Tin Tin

“…Abstract We present here the development of a high-throughput clonogenic methodology for the identification of novel radiation modulators, with critical and…”
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Binding and cytotoxicity of conjugated and recombinant fusion proteins targeted to the gonadotropin-releasing hormone receptor by LIN QI, NETT, Terry M, ALLEN, Matthew C, XIAOMING SHA, HARRISON, Gail S, FREDERICK, Barbara A, CRAWFORD, E. David, GLODE, L. Michael

“…Pokeweed antiviral protein (PAP) is a plant-derived, highly potent ribosome inactivating protein that causes inhibition of protein translation and rapid cell…”
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Abstract PO-080: Clonogenic high-throughput assay for screening radiation modulators by Frederick, Barbara, Gomes, Nathan, Su, Tin Tin

“…Abstract We present here the development of a high-throughput clonogenic methodology for the identification of novel radiation modulators, with critical and…”
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Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules by Ramteke, Anand, Ting, Harold, Agarwal, Chapla, Mateen, Samiha, Somasagara, Ranganathan, Hussain, Anowar, Graner, Michael, Frederick, Barbara, Agarwal, Rajesh, Deep, Gagan

“…Hypoxic conditions in prostate cancer (PCA) are associated with poor prognosis; however, precise mechanism/s through which hypoxia promotes malignant phenotype…”
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A High Throughput Screen with a Clonogenic Endpoint to Identify Radiation Modulators of Cancer by Gomes, Nathan P., Frederick, Barbara, Jacobsen, Jeremy R., Chapnick, Doug, Su, Tin Tin

“…Clonogenic assays evaluate the ability of single cells to proliferate and form colonies. This process approximates the regrowth and recurrence of tumors after…”
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Resveratrol Selectively Induces DNA Damage, Independent of Smad4 Expression, in Its Efficacy against Human Head and Neck Squamous Cell Carcinoma by TYAGI, Alpna, GU, Mallikarjuna, TAKAHATA, Takenori, FREDERICK, Barbara, AGARWAL, Chapla, SIRIWARDANA, Sunitha, AGARWAL, Rajesh, SCLAFANI, Robert A

“…Alterations in Smad4 signaling and its loss cause genomic instability and head and neck squamous cell carcinoma (HNSCC), suggesting that agents that target…”
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PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models by Hernandez, Ariel L, Young, Christian D, Bian, Li, Weigel, Kelsey, Nolan, Kyle, Frederick, Barbara, Han, Gangwen, He, Guanting, Devon Trahan, G, Rudolph, Michael C, Jones, Kenneth L, Oweida, Ayman J, Karam, Sana D, Raben, David, Wang, Xiao-Jing

“…loss causes genomic instability and the initiation/progression of head and neck squamous cell carcinoma (HNSCC). Here, we study whether loss sensitizes HNSCCs…”
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GnRH-PAP hormonotoxin targets cytotoxicity to prostate cancer cell lines by Qi, Lin, Nett, Terry M, Allen, Matthew C, Sha, Xiaoming, Harrison, Gail S, Frederick, Barbara A, Glode, L Michael

“…Pokeweed antiviral protein (PAP) is a plant-derived, highly potent ribosome inactivating protein that causes inhibition of protein translation and rapid cell…”
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Bouvardin is a Radiation Modulator with a Novel Mechanism of Action by Stickel, Stefanie A., Gomes, Nathan P., Frederick, Barbara, Raben, David, Su, Tin Tin

“…Protein synthesis is essential for growth, proliferation and survival of cells. Translation factors are overexpressed in many cancers and in preclinical…”
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Inhibiting Translation Elongation with SVC112 Suppresses Cancer Stem Cells and Inhibits Growth in Head and Neck Squamous Carcinoma by Keysar, Stephen B, Gomes, Nathan, Miller, Bettina, Jackson, Brian C, Le, Phuong N, Morton, J Jason, Reisinger, Julie, Chimed, Tugs-Saikhan, Gomez, Karina E, Nieto, Cera, Frederick, Barbara, Pronk, Gijsbertus J, Somerset, Hilary L, Tan, Aik-Choon, Wang, Xiao-Jing, Raben, David, Su, Tin Tin, Jimeno, Antonio

“…Cancer stem cells (CSC) drive growth, therapy resistance, and recurrence in head and neck squamous cell carcinoma (HNSCC). Regulation of protein translation is…”
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Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification by ROTHSCHILD, Brian L, SHIM, Ann H, RABEN, David, WEED, Scott A, AMMER, Amanda Gatesman, KELLEY, Laura C, IRBY, Kimberly B, HEAD, Julie A, LIN CHEN, VARELLA-GARCIA, Marileila, SACKS, Peter G, FREDERICK, Barbara

“…Carcinoma cell motility and invasion are prerequisites for tumor cell metastasis, which requires regulation of the actin cytoskeleton. Cortactin is an…”
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