Search Results - "Frederick, Andrea L."

Synthesis of BACE Inhibitor LY2886721. Part II. Isoxazolidines as Precursors to Chiral Aminothiazines, Selective Peptide Coupling, and a Controlled Reactive Crystallization by Hansen, Marvin M, Jarmer, Daniel J, Arslantas, Enver, DeBaillie, Amy C, Frederick, Andrea L, Harding, Molly, Hoard, David W, Hollister, Adrienne, Huber, Dominique, Kolis, Stanley P, Kuehne-Willmore, Jennifer E, Kull, Thomas, Laurila, Michael E, Linder, Ryan J, Martin, Thomas J, Martinelli, Joseph R, McCulley, Michael J, Richey, Rachel N, Starkey, Derek R, Ward, Jeffrey A, Zaborenko, Nikolay, Zweifel, Theo

“…An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a…”
Get full text

Synthesis of BACE Inhibitor LY2886721. Part I. An Asymmetric Nitrone Cycloaddition Strategy by Kolis, Stanley P, Hansen, Marvin M, Arslantas, Enver, Brändli, Lukas, Buser, Jonas, DeBaillie, Amy C, Frederick, Andrea L, Hoard, David W, Hollister, Adrienne, Huber, Dominique, Kull, Thomas, Linder, Ryan J, Martin, Thomas J, Richey, Rachel N, Stutz, Alfred, Waibel, Michael, Ward, Jeffrey A, Zamfir, Alexandru

“…A scalable, asymmetric synthesis of (3aS,6aS)-6a-(5-bromo-2-fluorophenyl)-1-((R)-1-phenylpropyl)­tetrahydro-1H,3H-furo­[3,4-c]­isoxazole, a key intermediate in…”
Get full text

Pilot-Scale Continuous Production of LY2886721: Amide Formation and Reactive Crystallization by Polster, Christopher S., Cole, Kevin P., Burcham, Christopher L., Campbell, Bradley M., Frederick, Andrea L., Hansen, Marvin M., Harding, Molly, Heller, Michael R., Miller, Michael T., Phillips, Joseph L., Pollock, Patrick M., Zaborenko, Nikolay

“…The design, development, and implementation of a pilot-scale continuous Schotten–Baumann amide bond formation and reactive crystallization to afford LY2886721…”
Get full text