Search Results - "Frederich, R"

Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes by Cannon, Christopher P, Pratley, Richard, Dagogo-Jack, Samuel, Mancuso, James, Huyck, Susan, Masiukiewicz, Urszula, Charbonnel, Bernard, Frederich, Robert, Gallo, Silvina, Cosentino, Francesco, Shih, Weichung J, Gantz, Ira, Terra, Steven G, Cherney, David Z.I, McGuire, Darren K

“…In this randomized trial, patients with type 2 diabetes and atherosclerotic cardiovascular disease received 5 mg or 15 mg of ertugliflozin or placebo once…”
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Saxagliptin improves glycaemic control and C-peptide secretion in latent autoimmune diabetes in adults (LADA) by Buzzetti, R., Pozzilli, P., Frederich, R., Iqbal, N., Hirshberg, B.

“…Background To assess the efficacy and tolerability of saxagliptin and C‐peptide secretion in patients with diagnosed type 2 diabetes classified as glutamic…”
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Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks by Pfützner, A., Paz-Pacheco, E., Allen, E., Frederich, R., Chen, R.

“…Aim: To assess the efficacy and safety of saxagliptin + metformin initial combination therapy compared with saxagliptin or metformin alone over 76 weeks…”
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Clinically relevant reductions in HbA1c without hypoglycaemia: results across four studies of saxagliptin by Karyekar, C S, Frederich, R, Ravichandran, S

“…In four 24-week controlled studies, the antihyperglycaemic efficacy of saxagliptin was demonstrated in patients with type 2 diabetes mellitus as add-on therapy…”
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POS-354 WORSENING KIDNEY DISEASE INFLUENCES THE EFFICACY OF ERTUGLIFLOZIN ON GLUCOSURIA-MEDIATED ENDPOINTS BUT DOES NOT INFLUENCE THE EFFICACY ON NATRIURESIS-RELATED ENDPOINTS: PRESPECIFIED ANALYSES FROM VERTIS CV by Cherney, D., Charbonnel, B., Cosentino, F., Pratley, R.E., Dagogo-Jack, S., Shih, W.J., McGuire, D.K., Frederich, R., Maldonado, M., Liu, J., Pong, A., Liu, C., Cannon, C.P.

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Long-term weight-loss maintenance : a meta-analysis of US studies by ANDERSON, James W, KONZ, Elizabeth C, FREDERICH, Robert C, WOOD, Constance L

“…Current perception is that participants of a structured weight-loss program regain all of their weight loss within 5 y. The objective was to examine the…”
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Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice by Mantzoros, C S, Qu, D, Frederich, R C, Susulic, V S, Lowell, B B, Maratos-Flier, E, Flier, J S

“…Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. C S Mantzoros , D…”
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Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue by CINTI, S, FREDERICH, R. C, ZINGARETTI, M. C, DE MATTEIS, R, FLIER, J. S, LOWELL, B. B

“…Leptin is synthesized exclusively by adipocytes and acts on the hypothalamus to regulate energy balance. Previous messenger RNA expression studies demonstrated…”
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Tissue-Specific Nutritional Regulation of Angiotensinogen in Adipose Tissue by Frederich, Robert C, Kahn, Barbara B, Peach, Michael J, Flier, Jeffrey S

“…Recent studies have found that angiotensinogen is expressed in white and brown fat pads, and adipocytes have been implicated as a primary source of…”
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Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action by Frederich, Robert C, Hamann, Andreas, Anderson, Stephen, Löllmann, Bettina, Lowell, Bradford B, Flier, Jeffrey S

“…The regulation of body weight and composition involves input from genes and the environment, demonstrated, for example, by the variable susceptibility of…”
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Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia by Sarraf, P, Frederich, R C, Turner, E M, Ma, G, Jaskowiak, N T, Rivet, 3rd, D J, Flier, J S, Lowell, B B, Fraker, D L, Alexander, H R

“…Several inflammatory cytokines, most notably tumor necrosis factor (TNF) and IL-1, induce anorexia and loss of lean body mass, common manifestations of acute…”
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Rosiglitazone amplifies the benefits of lifestyle intervention measures in long-standing type 2 diabetes mellitus by Reynolds, L. R., Konz, E. C., Frederich, R. C., Anderson, J. W.

“…Aims: To evaluate the efficacy of a lifestyle intervention programme including meal replacements and increased physical activity upon body weight, diabetes…”
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Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity by Frederich, R C, Löllmann, B, Hamann, A, Napolitano-Rosen, A, Kahn, B B, Lowell, B B, Flier, J S

“…The mutant gene responsible for obesity in the ob/ob mouse was recently identified by positional cloning (Zhang Y., R. Proenca, M. Maffel, M. Barone, L…”
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Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations by Mantzoros, C. S., Frederich, R. C., Qu, D., Lowell, B. B., Maratos-Flier, E., Flier, J. S.

“…Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y…”
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Efficacy of Ertugliflozin on Heart Failure–Related Events in Patients With Type 2 Diabetes Mellitus and Established Atherosclerotic Cardiovascular Disease: Results of the VERTIS CV Trial by Cosentino, Francesco, Cannon, Christopher P., Cherney, David Z.I., Masiukiewicz, Urszula, Pratley, Richard, Dagogo-Jack, Sam, Frederich, Robert, Charbonnel, Bernard, Mancuso, James, Shih, Weichung J., Terra, Steven G., Cater, Nilo B., Gantz, Ira, McGuire, Darren K.

“…BACKGROUND:In patients with type 2 diabetes mellitus, sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure (HHF). We…”
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Effects of ertugliflozin on kidney composite outcomes, renal function and albuminuria in patients with type 2 diabetes mellitus: an analysis from the randomised VERTIS CV trial by Cherney, David Z. I., Charbonnel, Bernard, Cosentino, Francesco, Dagogo-Jack, Samuel, McGuire, Darren K., Pratley, Richard, Shih, Weichung J., Frederich, Robert, Maldonado, Mario, Pong, Annpey, Cannon, Christopher P.

“…Aims/hypothesis In previous work, we reported the HR for the risk (95% CI) of the secondary kidney composite endpoint (time to first event of doubling of serum…”
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Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus by Ludwig, D S, Mountjoy, K G, Tatro, J B, Gillette, J A, Frederich, R C, Flier, J S, Maratos-Flier, E

“…Melanin-concentrating hormone (MCH) and alpha-melanocyte-stimulating hormone (alpha-MSH) demonstrate opposite actions on skin coloration in teleost fish. Both…”
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Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations by MANTZOROS, C. S, FREDERICH, R. C, QU, D, LOWELL, B. B, MARATOS-FLIER, E, FLIER, J. S

“…Brown adipose tissue (BAT) has the capacity for uncoupled mitochondrial respiration and is proposed to be a key site for regulating energy expenditure in…”
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Metabolic effects of insulin and insulin-like growth factor-I in endotoxemic rats during total parenteral nutrition feeding by Ling, Pei Ra, Lydon, Erin, Zhensheng, Qu, Frederich, Robert C., Bistrian, Bruce R.

“…The effects of insulin and insulin-like growth factor-I (IGF-I) on protein, energy, and glucose metabolism were examined in endotoxemic rats receiving total…”
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Ertugliflozin and Incident Obstructive Sleep Apnea: An Analysis from the VERTIS CV Trial by Wojeck, B.S., Inzucchi, S.E., Neeland, I.J., Mancuso, J.P., Frederich, R., Masiukiewicz, U., Cater, N.B., McGuire, D.K., Cannon, C.P., Yaggi, H.K.

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