Search Results - "Frederic Cadet"

Non-hemolytic peptide classification using a quantum support vector machine by Zhuang, Shengxin, Tanner, John, Wu, Yusen, Huynh, Du, Liu, Wei, Cadet, Xavier, Fontaine, Nicolas, Charton, Philippe, Damour, Cedric, Cadet, Frederic, Wang, Jingbo

“…Quantum machine learning (QML) is one of the most promising applications of quantum computation. Despite the theoretical advantages, it is still unclear…”
Get full text

Editorial: Machine learning, epistasis, and protein engineering: From sequence-structure-function relationships to regulation of metabolic pathways by Cadet, Frederic, Saavedra, Emma, Syren, Per-Olof, Gontero, Brigitte

Get full text

A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes by Cadet, Frédéric, Fontaine, Nicolas, Li, Guangyue, Sanchis, Joaquin, Ng Fuk Chong, Matthieu, Pandjaitan, Rudy, Vetrivel, Iyanar, Offmann, Bernard, Reetz, Manfred T.

“…Directed evolution is an important research activity in synthetic biology and biotechnology. Numerous reports describe the application of tedious…”
Get full text

A glance into the evolution of template-free protein structure prediction methodologies by Dhingra, Surbhi, Sowdhamini, Ramanathan, Cadet, Frédéric, Offmann, Bernard

“…Prediction of protein structures using computational approaches has been explored for over two decades, paving a way for more focused research and development…”
Get full text

The mutual and dynamic role of TSPO and ligands in their binding process: An example with PK-11195 by Rao, Rajas M., El Dhaybi, Ibaa, Cadet, Frédéric, Etchebest, Catherine, Diharce, Julien

“…Translocator protein (TSPO) is an 18 kDa transmembrane protein, localized primarily on the outer mitochondrial membrane. It has been found to be involved in…”
Get full text

Identification of flux checkpoints in a metabolic pathway through white-box, grey-box and black-box modeling approaches by Lo-Thong, Ophélie, Charton, Philippe, Cadet, Xavier F., Grondin-Perez, Brigitte, Saavedra, Emma, Damour, Cédric, Cadet, Frédéric

“…Metabolic pathway modeling plays an increasing role in drug design by allowing better understanding of the underlying regulation and controlling networks in…”
Get full text

Versatile Dimerisation Process of Translocator Protein (TSPO) Revealed by an Extensive Sampling Based on a Coarse-Grained Dynamics Study by Rao, Rajas, Diharce, Julien, Dugué, Bérénice, Ostuni, Mariano A, Cadet, Frédéric, Etchebest, Catherine

“…Translocator protein (TSPO), a mitochondrial membrane protein, has been extensively studied, and its role is still debated and continues to be enigmatic. From…”
Get full text

General Trends of the Camelidae Antibody VHHs Domain Dynamics by Vattekatte, Akhila Melarkode, Diharce, Julien, Rebehmed, Joseph, Cadet, Frédéric, Gardebien, Fabrice, Etchebest, Catherine, de Brevern, Alexandre G.

“…Conformational flexibility plays an essential role in antibodies’ functional and structural stability. They facilitate and determine the strength of…”
Get full text

Application of fourier transform and proteochemometrics principles to protein engineering by Cadet, Frédéric, Fontaine, Nicolas, Vetrivel, Iyanar, Ng Fuk Chong, Matthieu, Savriama, Olivier, Cadet, Xavier, Charton, Philippe

“…Connecting the dots between the protein sequence and its function is of fundamental interest for protein engineers. In-silico methods are useful in this quest…”
Get full text

Learning Epistasis and Residue Coevolution Patterns: Current Trends and Future Perspectives for Advancing Enzyme Engineering by Wittmund, Marcel, Cadet, Frederic, Davari, Mehdi D.

“…Engineering proteins and enzymes with the desired functionality has broad applications in molecular biology, biotechnology, biomedical sciences, health, and…”
Get full text

Regioselective glucosylation of (+)-catechin using a new variant of sucrose phosphorylase from Bifidobacterium adolescentis by Demonceaux, Marie, Goux, Marine, Hendrickx, Johann, Solleux, Claude, Cadet, Frédéric, Lormeau, Émilie, Offmann, Bernard, André-Miral, Corinne

“…Mutation Q345F in sucrose phosphorylase from ( SP) has shown to allow efficient (+)-catechin glucosylation yielding a regioisomeric mixture: (+)-catechin-3'-…”
Get more information

Flux prediction using artificial neural network (ANN) for the upper part of glycolysis by Ajjolli Nagaraja, Anamya, Fontaine, Nicolas, Delsaut, Mathieu, Charton, Philippe, Damour, Cedric, Offmann, Bernard, Grondin-Perez, Brigitte, Cadet, Frederic

“…The selection of optimal enzyme concentration in multienzyme cascade reactions for the highest product yield in practice is very expensive and time-consuming…”
Get full text

Insights into Comparative Modeling of VHH Domains by Vattekatte, Akhila Melarkode, Cadet, Frédéric, Gelly, Jean-Christophe, de Brevern, Alexandre G.

“…In the particular case of the Camelidae family, immunoglobulin proteins have evolved into a unique and more simplified architecture with only heavy chains. The…”
Get full text

VHH Structural Modelling Approaches: A Critical Review by Vishwakarma, Poonam, Vattekatte, Akhila Melarkode, Shinada, Nicolas, Diharce, Julien, Martins, Carla, Cadet, Frédéric, Gardebien, Fabrice, Etchebest, Catherine, Nadaradjane, Aravindan Arun, de Brevern, Alexandre G.

“…VHH, i.e., VH domains of camelid single-chain antibodies, are very promising therapeutic agents due to their significant physicochemical advantages compared to…”
Get full text

One‐shot optimization of multiple enzyme parameters: Tailoring glucose oxidase for pH and electron mediators by Ostafe, Raluca, Fontaine, Nicolas, Frank, David, Ng Fuk Chong, Matthieu, Prodanovic, Radivoje, Pandjaitan, Rudy, Offmann, Bernard, Cadet, Frédéric, Fischer, Rainer

“…Enzymes are biological catalysts with many industrial applications, but natural enzymes are usually unsuitable for industrial processes because they are not…”
Get full text

Publisher Correction: A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes by Cadet, Frédéric, Fontaine, Nicolas, Li, Guangyue, Sanchis, Joaquin, Chong, Matthieu Ng Fuk, Pandjaitan, Rudy, Vetrivel, Iyanar, Offmann, Bernard, Reetz, Manfred T.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Knowledge-based prediction of protein backbone conformation using a structural alphabet by Vetrivel, Iyanar, Mahajan, Swapnil, Tyagi, Manoj, Hoffmann, Lionel, Sanejouand, Yves-Henri, Srinivasan, Narayanaswamy, de Brevern, Alexandre G, Cadet, Frédéric, Offmann, Bernard

“…Libraries of structural prototypes that abstract protein local structures are known as structural alphabets and have proven to be very useful in various…”
Get full text

Quality assessment of VHH models by Nadaradjane, Aravindan Arun, Diharce, Julien, Rebehmed, Joseph, Cadet, Frédéric, Gardebien, Fabrice, Gelly, Jean-Christophe, Etchebest, Catherine, de Brevern, Alexandre G.

“…Heavy Chain Only Antibodies are specific to Camelid species. Despite the lack of the light chain variable domain, their heavy chain variable domain (VH)…”
Get full text

Structural variations within proteins can be as large as variations observed across their homologues by Vetrivel, Iyanar, de Brevern, Alexandre G., Cadet, Frédéric, Srinivasan, Narayanaswamy, Offmann, Bernard

“…Understanding the structural plasticity of proteins is key to understanding the intricacies of their functions and mechanistic basis. In the current study, we…”
Get full text

A Machine Learning Approach for Efficient Selection of Enzyme Concentrations and Its Application for Flux Optimization by Anamya Ajjolli Nagaraja, Philippe Charton, Xavier F. Cadet, Nicolas Fontaine, Mathieu Delsaut, Birgit Wiltschi, Alena Voit, Bernard Offmann, Cedric Damour, Brigitte Grondin-Perez, Frederic Cadet

“…The metabolic engineering of pathways has been used extensively to produce molecules of interest on an industrial scale. Methods like gene regulation or…”
Get full text