Search Results - "Fredebohm, Johannes"

Performance of Streck cfDNA Blood Collection Tubes for Liquid Biopsy Testing by Medina Diaz, Inga, Nocon, Annette, Mehnert, Daniel H, Fredebohm, Johannes, Diehl, Frank, Holtrup, Frank

“…Making liquid biopsy testing widely available requires a concept to ship whole blood at ambient temperatures while retaining the integrity of the cell-free DNA…”
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Broad spectrum of regorafenib activity on mutant KIT and absence of clonal selection in gastrointestinal stromal tumor (GIST): correlative analysis from the GRID trial by Jeffers, Michael, Kappeler, Christian, Kuss, Iris, Beckmann, Georg, Mehnert, Daniel H., Fredebohm, Johannes, Teufel, Michael

“…Background In the phase 3 GRID trial, regorafenib improved progression-free survival (PFS) independent of KIT mutations in exons 9 and 11. In this…”
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Clearance of ctDNA in triple-negative and HER2-positive breast cancer patients during neoadjuvant treatment is correlated with pathologic complete response by Ciriaco, Nikaoly, Zamora, Esther, Escrivá-de-Romaní, Santiago, Miranda Gómez, Ignacio, Jiménez Flores, José, Saura, Cristina, Sloane, Hillary, Starus, Anna, Fredebohm, Johannes, Georgieva, Lucy, Speight, Graham, Jones, Frederick, Ramón y Cajal, Santiago, Espinosa-Bravo, Martín, Peg, Vicente

“…Background: Although the standard of care is to perform surgery of primary breast cancer (BC) after neoadjuvant chemotherapy (NAC), for certain patients…”
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Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment by Rosenberg, Ari J, Izumchenko, Evgeny, Pearson, Alexander, Gooi, Zhen, Blair, Elizabeth, Karrison, Theodore, Juloori, Aditya, Ginat, Daniel, Cipriani, Nicole, Lingen, Mark, Sloane, Hillary, Edelstein, Daniel L, Keyser, Kirsten, Fredebohm, Johannes, Holtrup, Frank, Jones, Frederick S, Haraf, Daniel, Agrawal, Nishant, Vokes, Everett E

“…Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) has a favorable prognosis which has led to efforts to de-intensify treatment…”
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Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine by Fredebohm, Johannes, Wolf, Jonas, Hoheisel, Jörg D, Boettcher, Michael

“…Chemotherapy of advanced pancreatic cancer has mainly been gemcitabine-based for the past 15 years, with only limited effect. Recently, combination therapy…”
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Monitoring ctDNA RAS Mutational Status in Metastatic Colorectal Cancer: A Trial Protocol of RAS-trace and RAS-trace-2 Studies by Kataoka, Kozo, Yamada, Takeshi, Shiozawa, Manabu, Takase, Naoto, Ito, Kazuma, Yamazaki, Kentaro, Watanabe, Jun, Kudo, Toshihiro, Suto, Takeshi, Matsumoto, Toshihiko, Murata, Kohei, Suwa, Yusuke, Boku, Shogen, Yasui, Hisateru, Matsuhashi, Nobuhisa, Maeda, Atsuyuki, Sugimoto, Kiichi, Matsumoto, Yusuke, Yokota, Mitsuru, Fredebohm, Johannes, Mori, Keita, Ikeda, Masataka

“…Background: Spatial and temporal heterogeneities of RAS and other molecular genes should be considered in the treatment of metastatic colorectal cancer (mCRC)…”
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Pre-Analytical Evaluation of Streck Cell-Free DNA Blood Collection Tubes for Liquid Profiling in Oncology by Diaz, Inga Medina, Nocon, Annette, Held, Stefanie A E, Kobilay, Makbule, Skowasch, Dirk, Bronkhorst, Abel J, Ungerer, Vida, Fredebohm, Johannes, Diehl, Frank, Holdenrieder, Stefan, Holtrup, Frank

“…Excellent pre-analytical stability is an essential precondition for reliable molecular profiling of circulating tumor DNA (ctDNA) in oncological diagnostics…”
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Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs by Cheng, Xinlai, Kim, Jee Young, Ghafoory, Shahrouz, Duvaci, Tijen, Rafiee, Roya, Theobald, Jannick, Alborzinia, Hamed, Holenya, Pavlo, Fredebohm, Johannes, Merz, Karl-Heinz, Mehrabi, Arianeb, Hafezi, Mohammadreza, Saffari, Arash, Eisenbrand, Gerhard, Hoheisel, Jörg D., Wölfl, Stefan

“…Pancreatic ductal adenocarcinoma (PDAC) clinically has a very poor prognosis. No small molecule is available to reliably achieve cures. Meisoindigo is…”
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Detection of TP53 and PIK3CA Mutations in Circulating Tumor DNA Using Next-Generation Sequencing in the Screening Process for Early Breast Cancer Diagnosis by Rodriguez, Begona Jimenez, Córdoba, Gema Diaz, Aranda, Alicia Garrido, Álvarez, Martina, Vicioso, Luis, Pérez, Casilda Llácer, Hernando, Cristina, Bermejo, Begoña, Parreño, Ana Julve, Lluch, Ana, Ryder, Matthew B, Jones, Frederick S, Fredebohm, Johannes, Holtrup, Frank, Queipo-Ortuño, María Isabel, Alba, Emilio

“…Circulating tumor DNA (ctDNA) has emerged as a non-invasive "liquid biopsy" for early breast cancer diagnosis. We evaluated the suitability of ctDNA analysis…”
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Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system by Fredebohm, Johannes, Boettcher, Michael, Eisen, Christian, Gaida, Matthias M, Heller, Anette, Keleg, Shereen, Tost, Jörg, Greulich-Bode, Karin M, Hotz-Wagenblatt, Agnes, Lathrop, Mark, Giese, Nathalia A, Hoheisel, Jörg D

“…Standard cancer cell lines do not model the intratumoural heterogeneity situation sufficiently. Clonal selection leads to a homogeneous population of cells by…”
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Decoding pooled RNAi screens by means of barcode tiling arrays by Boettcher, Michael, Fredebohm, Johannes, Gholami, Amin Moghaddas, Hachmo, Yafit, Dotan, Iris, Canaani, Dan, Hoheisel, Jörg D

“…RNAi screens via pooled short hairpin RNAs (shRNAs) have recently become a powerful tool for the identification of essential genes in mammalian cells. In the…”
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Ultrasensitive Measurable Residual Disease (MRD) Detection in Acute Myeloid Leukemia (AML) Using a Targeted Next Generation Sequencing (NGS) Panel by Duchstein, Lara, Sloane, Hillary S, Fredebohm, Johannes, Ryder, Matthew

“…Assessment of MRD in AML is emerging as an important tool for refining risk classification and improving patient management and outcomes. MRD also shows…”
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A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype by Wolf, Jonas, Dewi, Dyah Laksmi, Fredebohm, Johannes, Müller-Decker, Karin, Flechtenmacher, Christa, Hoheisel, Jörg D, Boettcher, Michael

“…Breast cancer stem cells are suspected to be responsible for tumour recurrence, metastasis formation as well as chemoresistance. Consequently, great efforts…”
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Next-generation sequencing (NGS) profiling of matched tumor and circulating tumor DNA (ctDNA) in head and neck squamous cell carcinoma (HNSCC) by Economopoulou, Panagiota, Spathis, Aris, Kotsantis, Ioannis, Maratou, Eirini, Anastasiou, Maria, Moutafi, Myrto K., Kirkasiadou, Maria, Pantazopoulos, Anastasios, Giannakakou, Maria, Edelstein, Daniel L., Sloane, Hillary, Fredebohm, Johannes, Jones, Frederick S, Kyriazoglou, Anastasios, Gavrielatou, Niki, Foukas, Periklis, Panayiotides, Ioannis, Psyrri, Amanda

“…•In a cohort of patients with head and neck cancer, concordance of genotyping results between tumor DNA and ctDNA was 53.3%.•TP53 mutations were most commonly…”
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Abstract LB053: Clinical evaluation of NGS-based liquid biopsy genotyping in non-small cell lung cancer (NSCLC) patients by Sloane, Hillary, Sathyanarayan, Priya, Edelstein, Daniel, Jones, Frederick, Preston, Jennifer, Wu, Sam, Los, Jenna, Duchstein, Lara, Fredebohm, Johannes, Wichner, Katharina, Heim, Denise, Holtrup, Frank, Quinn, Hannah, Feller-Kopman, David

“…Abstract Background: Access to molecular testing for metastatic NSCLC (mNSCLC) patients has been improved by circulating tumor DNA (ctDNA) based liquid…”
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Ultra-sensitive detection and quantification of HPV DNA in the plasma of patients with oropharyngeal squamous cell carcinoma (OPSCC) enrolled in the OPTIMA 2 treatment de-escalation trial by Sloane, Hillary, Izumchenko, Evgeny, Mattox, Austin, Hasina, Rifat, Patel, Aashay, Jones, Frederick, Quinn, Hannah, Keyser, Kirsten, Fredebohm, Johannes, Holtrup, Frank, Pearson, Alexander T., Vokes, Everett E., Seiwert, Tanguy Y., Edelstein, Daniel L., Rosenberg, Ari, Agrawal, Nishant

“…Abstract only 6048 Background: Human papillomavirus (HPV) infection is a primary factor driving the increasing incidence of OPSCC. As patients with HPV+ OPSCC…”
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The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators by Kaistha, Brajesh P, Krattenmacher, Anja, Fredebohm, Johannes, Schmidt, Harald, Behrens, Diana, Widder, Miriam, Hackert, Thilo, Strobel, Oliver, Hoheisel, Jörg D, Gress, Thomas M, Buchholz, Malte

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. With an overall five-year survival rate remaining below 6%, there is an…”
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Abstract 403: Performance assessment of highly sensitive NGS assay for TP53 by Fredebohm, Johannes, Mehnert, Daniel, Löber, Ann-Kathrin, Shimizu, Hiroyuki, Holtrup, Frank, Diehl, Frank

“…Abstract We have designed a highly sensitive assay based on the Safe-Sequencing technology(1) to detect de novo mutations in the TP53 gene. A custom panel was…”
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Abstract A019: Analytical and clinical validation of HPV-SEQ, an NGS-based liquid biopsy platform for detection and quantification of human papilloma virus circulating tumor DNA by Eickelschulte, Samaneh, Starus, Anna, Murray, David H, Keyser, Anja K, Schauer, Oliver, Fredebohm, Johannes, Jones, Frederick, Pearson, Alexander T, Vokes, Everett E, Rosenberg, Ari J, Agrawal, Nishant, Izumchenko, Evgeny

“…Abstract Human papillomavirus (HPV) infection is the primary causative factor driving the rising incidence of oropharyngeal squamous cell carcinoma (OPSCC)…”
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Detection and Quantification of KIT Mutations in ctDNA by Plasma Safe-SeqS by Fredebohm, Johannes, Mehnert, Daniel H, Löber, Ann-Kathrin, Holtrup, Frank, van Rahden, Vanessa, Angenendt, Philipp, Diehl, Frank

“…We have designed a highly sensitive assay based on the Safe-SeqS technology to detect de novo mutations in the KIT gene and tested its performance. This assay…”
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