Search Results - "Fred Wong, W.S."

Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease by Mei, Dan, Tan, W.S. Daniel, Tay, Yvonne, Mukhopadhyay, Amartya, Wong, W.S. Fred

“…Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation with persistent respiratory symptoms. Current therapeutics for COPD are…”
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Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism by Gan, Phyllis X.L., Liao, Wupeng, Lim, Hui Fang, Wong, W.S. Fred

“…Severe asthma is a difficult-to-treat chronic airway inflammatory disease requiring systemic corticosteroids to achieve asthma control. It has recently been…”
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House dust mite–induced asthma causes oxidative damage and DNA double-strand breaks in the lungs by Chan, Tze Khee, BSc, Loh, Xin Yi, BSc, Peh, Hong Yong, BSc, Tan, W.N. Felicia, BSc, Tan, W.S. Daniel, BSc, Li, Na, PhD, Tay, Ian J.J., BEng, Wong, W.S. Fred, PhD, Engelward, Bevin P., ScD

“…Background Asthma is related to airway inflammation and oxidative stress. High levels of reactive oxygen and nitrogen species can induce cytotoxic DNA damage…”
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Degradation of MK2 with natural compound andrographolide: A new modality for anti-inflammatory therapy by Tran, Quy T.N., Gan, Phyllis X.L., Liao, Wupeng, Mok, Yu Keung, Chai, Christina L.L., Wong, W.S. Fred

“…The p38MAPK-MK2 signaling axis functions as an initiator of inflammation. Targeting the p38MAPK-MK2 signaling axis represents a direct therapeutic intervention…”
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The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent by Tran, Quy T.N., Wong, W.S. Fred, Chai, Christina L.L.

“…In this study we report, for the first time, the synthesis of the natural product calcaratarin D via a stereo- and regio-selective aldol condensation with…”
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Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma by Li, Andrew, Chan, Hiang Ping, Gan, Phyllis X.L., Liew, Mei Fong, Wong, W.S. Fred, Lim, Hui-Fang

“…Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group…”
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Role of mammalian chitinases in asthma by Shuhui, Lim, Mok, Yu-Keung, Wong, W S Fred

“…Asthma is a chronic inflammatory disease characterized by airway inflammation, mucus hypersecretion and airway hyperresponsiveness. Mechanisms underlying the…”
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Ribosomal Protein S3 Gene Silencing Protects Against Cigarette Smoke-Induced Acute Lung Injury by Dong, Jinrui, Liao, Wupeng, Peh, Hong Yong, Tan, W.S. Daniel, Zhou, Shuo, Wong, W.S. Fred

“…Chronic obstructive pulmonary disease (COPD) is estimated to be the third leading cause of death by 2030. Transcription factor NF-κB may play a critical role…”
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Characterization of Th2 Induced Bronchial Associated Lymphoid Tissue (BALT) in a Mouse Model of Asthma by Kemeny, David M., BSc, PhD, FRCPath, Chua, Yen L., BSc, MSc, Huang, Chiung-Hui, PhD, Liong, Ka Hang, Wong, Kenneth, Zhou, Sophie Q, Tang, Yafang, Low, Michelle C.P, Zhang, Yongliang, Wong, Fred W.S

“…By transfer of Th2 polarized transgenic CD4 T cells we have produced a localized lung inflammatory response that is characterized by hyper-eosinophilia, smooth…”
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Antigen-specific effector CD8 T cells regulate allergic responses via IFN-γ and dendritic cell function by Tang, Yafang, BSc, Guan, Shou Ping, BSc, Chua, Benson Y.L., BSc, Zhou, Qian, BSc, Ho, Adrian W.S., BSc, Wong, Kenneth H.S., BSc, Wong, Kok Loon, PhD, Wong, W.S. Fred, PhD, Kemeny, David M., PhD, FRCPath

“…Background Previous studies have shown that CD8 T cells can both prevent and cause allergic responses. However, the underlying mechanisms remain to be…”
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Andrographolide attenuates interleukin-1β-stimulated upregulation of chemokine CCL5 and glial fibrillary acidic protein in astrocytes by Wong, Siew-Ying, Chan, Su-Jing, Wong, W.S Fred, Wong, Peter T.-H, Lai, Mitchell K.P

“…Andrographolide is a bioactive molecule isolated from Andrographis paniculata with anticancer and anti-inflammatory activities. In this study, we tested the…”
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Sphingosine kinase and sphingosine 1-phosphate in asthma by Lai, Wen-Qi, Wong, W S Fred, Leung, Bernard P

“…Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell…”
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Increased lungkine and chitinase levels in allergic airway inflammation: A proteomics approach by Zhao, Jing, Zhu, Hua, Wong, Chui Hong, Leung, Ka Yin, Wong, W.S. Fred

“…Asthma is a chronic inflammatory disease characterized by pulmonary eosinophilia and airway hyperresponsiveness. Mechanisms underlying the pathogenesis of…”
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An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model by Duan, Wei, Aguinaldo Datiles, Ana M.K., Leung, Bernard P., Vlahos, Chris J., Wong, W.S. Fred

“…Phosphoinositide 3-kinase (PI3K) exhibits broad functional effects in immune cells. We investigated the role of PI3K in allergic airway inflammation using…”
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Dexamethasone alters bronchoalveolar lavage fluid proteome in a mouse asthma model by Zhao, Jing, Yeong, Lai Han, Wong, W S Fred

“…Glucocorticoid is the most effective anti-inflammatory agent for asthma. The spectrum of protein targets that can be regulated by glucocorticoid in asthma is…”
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Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases by Cheong, Dorothy H.J., Tan, Daniel W.S., Wong, Fred W.S., Tran, Thai

“…[Display omitted] Molecular targets modulated by artemisinins in respiratory diseases. Artemisinins are sesquiterpene lactones with a peroxide moiety that are…”
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Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol by Peh, Hong Yong, Tan, W S Daniel, Liao, Wupeng, Wong, W S Fred

“…The discovery of vitamin E (α-tocopherol) began in 1922 as a vital component required in reproduction. Today, there are eight naturally occurring vitamin E…”
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Artemisinins: Pharmacological actions beyond anti-malarial by HO, Wanxing Eugene, HONG YONG PEH, TZE KHEE CHAN, WONG, W. S. Fred

“…Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally derived from Artemisia annua L. The anti-malarial action of…”
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Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action by Tan, W.S. Daniel, Liao, Wupeng, Zhou, Shuo, Wong, W.S. Fred

“…[Display omitted] Andrographis paniculata has long been part of the traditional herbal medicine system in Asia and in Scandinavia. Andrographolide was isolated…”
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Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases by Gan, Phyllis X.L., Zhang, Shanshan, Fred Wong, W.S.

“…[Display omitted] Metabolic reprogramming underlies the etiology and pathophysiology of respiratory diseases such as asthma, idiopathic pulmonary fibrosis…”
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