Search Results - "Freccero, Mauro"

Water-Soluble Naphthalene Diimides as Singlet Oxygen Sensitizers by Doria, Filippo, Manet, Ilse, Grande, Vincenzo, Monti, Sandra, Freccero, Mauro

“…Bromo- and/or alkylamino-substituted and hydrosoluble naphthalene diimides (NDIs) were synthesized to study their multimodal photophysical and photochemical…”
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Selective targeting of mutually exclusive DNA G-quadruplexes: HIV-1 LTR as paradigmatic model by Tassinari, Martina, Zuffo, Michela, Nadai, Matteo, Pirota, Valentina, Sevilla Montalvo, Adriana Carolina, Doria, Filippo, Freccero, Mauro, Richter, Sara N

“…Abstract Targeting of G-quadruplexes, non-canonical conformations that form in G-rich regions of nucleic acids, has been proposed as a novel therapeutic…”
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On the binding of naphthalene diimides to a human telomeric G-quadruplex multimer model by Pirota, Valentina, Platella, Chiara, Musumeci, Domenica, Benassi, Alessandra, Amato, Jussara, Pagano, Bruno, Colombo, Giorgio, Freccero, Mauro, Doria, Filippo, Montesarchio, Daniela

“…To selectively target telomeric G-quadruplex (G4) DNA, monomeric and dimeric naphthalene diimides (NDIs) were investigated as binders of multimeric G4…”
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A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids by Nadai, Matteo, Doria, Filippo, Scalabrin, Matteo, Pirota, Valentina, Grande, Vincenzo, Bergamaschi, Greta, Amendola, Valeria, Winnerdy, Fernaldo Richtia, Phan, Anh Tuân, Richter, Sara N, Freccero, Mauro

“…A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the…”
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Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands by Platella, Chiara, Musumeci, Domenica, Arciello, Angela, Doria, Filippo, Freccero, Mauro, Randazzo, Antonio, Amato, Jussara, Pagano, Bruno, Montesarchio, Daniela

“…Target selectivity is one of the main challenges in the search for small molecules able to act as effective and non-toxic anticancer and/or antiviral drugs. To…”
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A Photoreactive G-Quadruplex Ligand Triggered by Green Light by Nadai, Matteo, Doria, Filippo, Germani, Luca, Richter, Sara N., Freccero, Mauro

“…A photoreactive molecular dye targeting the G‐quadruplex nucleic acid (G4) of the human telomeric sequence Tel22, and several mutated analogues, was activated…”
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Selective Binding and Redox-Activity on Parallel G-Quadruplexes by Pegylated Naphthalene Diimide-Copper Complexes by Pirota, Valentina, Lunghi, Enrico, Benassi, Alessandra, Crespan, Emmanuele, Freccero, Mauro, Doria, Filippo

“…G-quadruplexes (G4s) are higher-order supramolecular structures, biologically important in the regulation of many key processes. Among all, the recent…”
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Trifunctionalized Naphthalene Diimides and Dimeric Analogues as G-Quadruplex-Targeting Anticancer Agents Selected by Affinity Chromatography by Platella, Chiara, Pirota, Valentina, Musumeci, Domenica, Rizzi, Federica, Iachettini, Sara, Zizza, Pasquale, Biroccio, Annamaria, Freccero, Mauro, Montesarchio, Daniela, Doria, Filippo

“…A focused library of newly designed monomeric and dimeric naphthalene diimides (NDIs) was analyzed in its ability to recognize specific G-quadruplex (G4)…”
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Photoactivatable V‐Shaped Bifunctional Quinone Methide Precursors as a New Class of Selective G‐quadruplex Alkylating Agents by Lena, Alberto, Benassi, Alessandra, Stasi, Michele, Saint‐Pierre, Christine, Freccero, Mauro, Gasparutto, Didier, Bombard, Sophie, Doria, Filippo, Verga, Daniela

“…Combining the selectivity of G‐quadruplex (G4) ligands with the spatial and temporal control of photochemistry is an emerging strategy to elucidate the…”
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Towards Building Blocks for Supramolecular Architectures Based on Azacryptates by Miljkovic, Ana, La Cognata, Sonia, Bergamaschi, Greta, Freccero, Mauro, Poggi, Antonio, Amendola, Valeria

“…In this work, we report the synthesis of a new bis(tris(2-aminoethyl)amine) azacryptand L with triphenyl spacers. The binding properties of its dicopper…”
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Down-Regulation of the Androgen Receptor by G‑Quadruplex Ligands Sensitizes Castration-Resistant Prostate Cancer Cells to Enzalutamide by Tassinari, Martina, Cimino-Reale, Graziella, Nadai, Matteo, Doria, Filippo, Butovskaya, Elena, Recagni, Marta, Freccero, Mauro, Zaffaroni, Nadia, Richter, Sara N, Folini, Marco

“…Stabilization of the G-quadruplexes (G4s) within the androgen receptor (AR) gene promoter to block transcription may represent an innovative approach to…”
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Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents by Di Antonio, Marco, Doria, Filippo, Richter, Sara N, Bertipaglia, Carolina, Mella, Mariella, Sissi, Claudia, Palumbo, Manlio, Freccero, Mauro

“…We have developed novel G-quadruplex (G-4) ligand/alkylating hybrid structures, tethering the naphthalene diimide moiety to quaternary ammonium salts of…”
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Naphthalene diimide‐derivatives G‐quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells by Muoio, Daniela, Berardinelli, Francesco, Leone, Stefano, Coluzzi, Elisa, di Masi, Alessandra, Doria, Filippo, Freccero, Mauro, Sgura, Antonella, Folini, Marco, Antoccia, Antonio

“…In the present paper, the biological effects of three different naphthalene diimides (NDIs) G‐quadruplex (G4) ligands (H‐NDI‐Tyr, H‐NDI‐NMe2, and…”
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Photogeneration and Reactivity of Naphthoquinone Methides as Purine Selective DNA Alkylating Agents by Verga, Daniela, Nadai, Matteo, Doria, Filippo, Percivalle, Claudia, Di Antonio, Marco, Palumbo, Manlio, Richter, Sara N, Freccero, Mauro

“…A one-step protecting-group-free synthesis of both 6-hydroxy-naphthalene-2-carbaldehyde and the bifunctional binaphthalenyl derivative afforded…”
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Oxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Binding by Doria, Filippo, Pirota, Valentina, Petenzi, Michele, Teulade-Fichou, Marie-Paule, Verga, Daniela, Freccero, Mauro

“…Non-macrocyclic heteroaryls represent a valuable class of ligands for nucleic acid recognition. In this regard, non-macrocyclic pyridyl polyoxazoles and…”
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A bimodal fluorescent and photocytotoxic naphthalene diimide for theranostic applications by Salvati, Erica, Doria, Filippo, Manoli, Francesco, D'Angelo, Carmen, Biroccio, Annamaria, Freccero, Mauro, Manet, Ilse

“…We report on the potential of a water-soluble tetracationic quaternary ammonium naphthalene diimide (NDI) as multifunctional agent of interest for theranostic…”
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Synthesis, Binding Properties, and Differences in Cell Uptake of G‐Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates by Arévalo‐Ruiz, Matilde, Doria, Filippo, Belmonte‐Reche, Efres, De Rache, Aurore, Campos‐Salinas, Jenny, Lucas, Ricardo, Falomir, Eva, Carda, Miguel, Pérez‐Victoria, José María, Mergny, Jean‐Louis, Freccero, Mauro, Morales, Juan Carlos

“…The G‐quadruplexes (G4s) are currently being explored as therapeutic targets in cancer and other pathologies. Six carbohydrate naphthalene diimide conjugates…”
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Design of Disruptors of the Hsp90-Cdc37 Interface by D'Annessa, Ilda, Hurwitz, Naama, Pirota, Valentina, Beretta, Giovanni Luca, Tinelli, Stella, Woodford, Mark, Freccero, Mauro, Mollapour, Mehdi, Zaffaroni, Nadia, Wolfson, Haim, Colombo, Giorgio

“…The molecular chaperone Hsp90 is a ubiquitous ATPase-directed protein responsible for the activation and structural stabilization of a large clientele of…”
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A Fragment-Based Approach for the Development of G-Quadruplex Ligands: Role of the Amidoxime Moiety by Tassinari, Martina, Lena, Alberto, Butovskaya, Elena, Pirota, Valentina, Nadai, Matteo, Freccero, Mauro, Doria, Filippo, Richter, Sara N

“…G-quadruplex (G4) nucleic acid structures have been reported to be involved in several human pathologies, including cancer, neurodegenerative disorders and…”
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Photosensitized Oxidation of Sulfides: Discriminating between the Singlet-Oxygen Mechanism and Electron Transfer Involving Superoxide Anion or Molecular Oxygen by Bonesi, Sergio M., Manet, Ilse, Freccero, Mauro, Fagnoni, Maurizio, Albini, Angelo

“…The oxidation of diethyl and diphenyl sulfide photosensitized by dicyanoanthracene (DCA), N‐methylquinolinium tetrafluoroborate (NMQ+), and triphenylpyrylium…”
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