Search Results - "Frazier, J M"

Long-term behavioral impairment following acute embryonic ethanol exposure in zebrafish by Bailey, J.M, Oliveri, A.N, Zhang, C, Frazier, J.M, Mackinnon, S, Cole, G.J, Levin, E.D

“…Abstract Background Developmental exposure to ethanol has long been known to cause persisting neurobehavioral impairment. However, the neural and behavioral…”
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Cadmium Uptake Kinetics in Rat Hepatocytes: Correction for Albumin Binding by DelRaso, N. J., Foy, B. D., Gearhart, J. M., Frazier, J. M.

“…The relationship between cytotoxicity and kinetics of cadmium uptake was investigated in primary rat hepatocyte cultures. Primary rat hepatocytes were exposed…”
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Simple Tools for Rapid Diagnostics and Decision Making by Olsen, N., Woodell, L., Frazier, M. J., Thornton, M., Karasev, A. V.

“…Acute decision making requires accurate information to mitigate risk in producing and storing a potato crop. Unfortunately, sometimes those decisions need to…”
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Simulation of Trichloroacetic Acid Kinetics in the Isolated Perfused Rat Liver Using a Biologically Based Kinetic Model by Toxopeus, Corike, Frazier, J. M.

“…Trichloroacetic acid (TCA) is a contaminant of drinking water. It induces peroxisome proliferation in livers of rats and mice and is hepatocarcinogenic in the…”
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QSAR modeling of oxidative stress in vitro following hepatocyte exposures to halogenated methanes by Geiss, K.T, Frazier, J.M

“…Volatile halogenated aliphatic compounds are among those chemicals that can cause oxidative stress in vitro and in vivo. Relationships can be identified…”
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Kinetic modeling of slow dissociation of bromosulphophthalein from albumin in perfused rat liver : Toxicological implications by FOY, B. D, TOXOPEUS, C, FRAZIER, J. M

“…Due to strong binding between organic anions and albumin, the kinetics of the binding process must be carefully considered in biologically-based models used…”
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Predictive toxicodynamics: Empirical/mechanistic approaches by Frazier, J.M.

“…A major objective of the toxicological sciences is to predict the in vivo toxicological consequences of human exposure to pure chemicals, complex mixtures and…”
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In vitro toxicities of experimental jet fuel system ice-inhibiting agents by Geiss, K.T, Frazier, J.M

“…One research emphasis within the Department of Defense has been to seek the replacement of operational compounds with alternatives that pose less potential…”
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EFFECT OF CULTURE CONDITIONS PRIOR TO EXPOSURE ON CADMIUM CYTOTOXICITY IN PRIMARY RAT HEPATOCYTES by Delraso, N J, Frazier, J M

“…Primary rat hepatocytes area useful research tool for direct investigation of hepatotoxic effects of chemicals or drugs at the cellular level. USEPA's…”
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Application of in vitro systems to the prediction of in vivo biokinetics by Frazier, J.M.

“…The kinetics of xenobiotics in biological systems are a critical factor in determining the site and degree of toxicological responses observed. Historically,…”
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Kinetics of Trichloroacetic Acid and Dichloroacetic Acid in the Isolated Perfused Rat Liver by Toxopeus, Corike, Frazier, John M.

“…Trichloroacetic acid (TCA) and dichloroacetic acid (DCA) are environmental contaminants that are suspected human carcinogens. To obtain more detail on the role…”
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Interdisciplinary approach to toxicity test development and validation by Frazier, J.M.

“…Toxicological processes are complex interactions of biological systems at various levels of organization. These interactions evolve in time in response to the…”
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In Vivo Kinetics of Trichloroacetate in Male Fischer 344 Rats by Yu, Kyung O., Barton, Hugh A., Mahle, Deirdre A., Frazier, John M.

“…Trichloroacetate (TCA) is a toxicologically important metabolite of the industrial solvents trichloroethylene and tetrachloroethylene, and a by-product of the…”
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Cellular Toxicity of Hydrazine in Primary Rat Hepatocytes by Hussain, Saber M., Frazier, John M.

“…Hydrazine (HzN) is an aircraft fuel and propellant used by the U.S. Air Force. The current study was undertaken to evaluate the acute toxicity of HzN in…”
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Protective effect of metallothionein on cadmium toxicity in isolated rat hepatocytes by Din, W S, Frazier, J M

“…An isolated rat hepatocyte preparation was used to study the cellular toxicity of cadmium and the protective effects of metallothionein on cadmium-induced…”
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Cadmium kinetics in oysters--a comparative study of Crassostrea gigas and Ostrea edulis by Frazier, J.M, George, S.G

“…The accumulation of cadmium was investigated in two species of oysters (Crassostrea gigas and Ostrea edulis ) from two different environments and in oysters of…”
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CIPC residues on stored Russet Burbank potatoes: 1. Maximum label application by Kleinkopf, G. E., Brandt, T. L., Frazier, M. J., Möller, Gregory

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The distribution and binding of zinc in the hippocampus by Sato, SM, Frazier, JM, Goldberg, AM

“…Quantitative and qualitative studies suggest that zinc is concentrated in the mossy fiber boutons of the hippocampus and is believed to exist as a chelatable…”
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Abnormal hepatic copper storage in a teleost fish (Morone americana) by Bunton, T E, Baksi, S M, George, S G, Frazier, J M

“…Excessive copper storage in livers of feral white perch (Morone americana) from the Chesapeake Bay is described. Age-related, progressive accumulation of…”
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A theoretical model for simulating the outcome of mechanism based in vitro toxicity testing strategies by Frazier, John M

“…In order to investigate the fundamental principles that influence the optimal selection of toxicity test methods for the evaluation of chemical hazards, it is…”
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